EMSLR

Summary

EMSLR (E2F1 mRNA stabilizing lncRNA, HGNC:54408) is a long non-coding RNA gene on chromosome 7q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54408
Approved symbol	EMSLR
Name	E2F1 mRNA stabilizing lncRNA
Location	7q22.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	EMS, BCCE4
Ensembl gene	ENSG00000232445
Ensembl biotype	lncRNA
OMIM	618575
Entrez	101927746
RNAcentral	URS0000A76561 — lncRNA, 1098 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000419422, ENST00000663483, ENST00000849561

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419422 — 3 exons

Exon	Start	End
ENSE00001651575	101310484	101311343
ENSE00001680564	101308296	101308548
ENSE00003887252	101309614	101309694

Expression profiles

Bgee: expression breadth ubiquitous, 140 present calls, max score 85.98.

FANTOM5 (CAGE): breadth broad, TPM avg 4.2537 / max 149.3065, expressed in 765 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
80194	4.2537	765

Top tissues by expression

227 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	85.98	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.13	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.31	gold quality
body of pancreas	UBERON:0001150	68.32	gold quality
cortical plate	UBERON:0005343	66.02	gold quality
pancreas	UBERON:0001264	65.13	gold quality
esophagus mucosa	UBERON:0002469	64.19	gold quality
mucosa of transverse colon	UBERON:0004991	63.98	gold quality
ventricular zone	UBERON:0003053	63.03	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.69	gold quality
oocyte	CL:0000023	62.46	silver quality
right lobe of liver	UBERON:0001114	61.80	gold quality
lower esophagus mucosa	UBERON:0035834	61.52	gold quality
ganglionic eminence	UBERON:0004023	61.22	gold quality
islet of Langerhans	UBERON:0000006	60.39	gold quality
muscle of leg	UBERON:0001383	59.31	gold quality
body of stomach	UBERON:0001161	58.89	gold quality
gastrocnemius	UBERON:0001388	58.62	gold quality
lower lobe of lung	UBERON:0008949	58.24	silver quality
prefrontal cortex	UBERON:0000451	58.15	gold quality
esophagus	UBERON:0001043	58.15	gold quality
liver	UBERON:0002107	57.10	gold quality
adult mammalian kidney	UBERON:0000082	56.99	gold quality
stomach	UBERON:0000945	56.70	gold quality
leukocyte	CL:0000738	55.90	silver quality
cortex of kidney	UBERON:0001225	55.27	gold quality
metanephros cortex	UBERON:0010533	54.63	gold quality
monocyte	CL:0000576	54.15	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	54.15	gold quality
transverse colon	UBERON:0001157	53.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.51

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Study reports the lncRNA E2F1 mRNA stabilizing factor (EMS) as a direct c-Myc transcriptional target. EMS functions as an oncogenic molecule by promoting G1/S cell cycle progression. EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression. Furthermore, EMS is able to connect c-Myc to cell cycle control and tumorigenesis via modulating E2F1 mRNA stability. (PMID:31262817)
• Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis. (PMID:35022235)
• E2F1-induced lncRNA, EMSLR regulates lncRNA LncPRESS1. (PMID:35169159)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.