EMX2OS

Summary

EMX2OS (EMX2 opposite strand/antisense RNA, HGNC:18511) is a long non-coding RNA gene on chromosome 10q26.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18511
Approved symbol	EMX2OS
Name	EMX2 opposite strand/antisense RNA
Location	10q26.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00045, EMX2-AS1
Ensembl gene	ENSG00000229847
Ensembl biotype	lncRNA
OMIM	607637
Entrez	196047
RNAcentral	URS000073968D — lncRNA, 7282 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000412075, ENST00000423419, ENST00000424371, ENST00000440007, ENST00000450314, ENST00000551288, ENST00000611404, ENST00000656309, ENST00000659715, ENST00000748259, ENST00000748260, ENST00000748261

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412075 — 2 exons

Exon	Start	End
ENSE00001629082	117476357	117477173
ENSE00001717287	117473215	117473422

Expression profiles

Bgee: expression breadth ubiquitous, 205 present calls, max score 96.95.

FANTOM5 (CAGE): breadth broad, TPM avg 6.7822 / max 249.6683, expressed in 565 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111614	1.3551	341
111611	1.1275	316
111612	1.0638	321
111616	0.8741	334
111615	0.6560	260
111608	0.4726	173
111618	0.3522	139
111617	0.3044	169
111610	0.2611	126
111609	0.1652	85

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus epididymis	UBERON:0004359	96.95	gold quality
kidney epithelium	UBERON:0004819	96.87	gold quality
caput epididymis	UBERON:0004358	96.52	gold quality
cauda epididymis	UBERON:0004360	96.13	gold quality
seminal vesicle	UBERON:0000998	96.03	gold quality
oviduct epithelium	UBERON:0004804	94.87	gold quality
body of uterus	UBERON:0009853	94.30	gold quality
right uterine tube	UBERON:0001302	94.21	gold quality
fallopian tube	UBERON:0003889	93.01	gold quality
endocervix	UBERON:0000458	92.21	gold quality
myometrium	UBERON:0001296	92.11	gold quality
germinal epithelium of ovary	UBERON:0001304	92.07	gold quality
ventricular zone	UBERON:0003053	90.35	gold quality
adult mammalian kidney	UBERON:0000082	90.25	gold quality
uterus	UBERON:0000995	89.73	gold quality
left uterine tube	UBERON:0001303	89.68	gold quality
kidney	UBERON:0002113	89.59	gold quality
renal medulla	UBERON:0000362	89.06	gold quality
metanephros cortex	UBERON:0010533	88.67	gold quality
caudate nucleus	UBERON:0001873	88.64	gold quality
entorhinal cortex	UBERON:0002728	88.32	gold quality
decidua	UBERON:0002450	88.18	gold quality
uterine cervix	UBERON:0000002	88.02	gold quality
amygdala	UBERON:0001876	87.64	gold quality
temporal lobe	UBERON:0001871	87.34	gold quality
endometrium	UBERON:0001295	87.20	gold quality
ectocervix	UBERON:0012249	86.12	gold quality
endothelial cell	CL:0000115	86.08	silver quality
ganglionic eminence	UBERON:0004023	86.04	gold quality
primary visual cortex	UBERON:0002436	85.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	20.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• In the three variants of papillary thyroid cancer (PTC), EMX2 was significantly downregulated in classical PTC, while EMX2OS was significantly downregulated in follicular and classical PTC, compared with adjacent normal tissues. Kaplan-Meier survival curves showed that EMX2 and EMX2OS expression was not related to relapse-free survival in follicular PTC. (PMID:30576338)
• EMX2OS plays a prognosis-associated enhancer RNA role in gastric cancer. (PMID:34731149)
• EMX2OS Delays Wilms’Tumor Progression via Targeting miR-654-3p. (PMID:35181613)
• EMX2OS targeting IGF2BP1 represses Wilms’ tumour stemness,epithelial-mesenchymal transition and metastasis. (PMID:36722215)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.