ENTR1

Summary

ENTR1 (endosome associated trafficking regulator 1, HGNC:10667) is a protein-coding gene on chromosome 9q34.3, encoding Endosome-associated-trafficking regulator 1 (Q96C92). Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis.

Involved in several processes, including endocytic recycling; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Located in several cellular components, including endosome; microtubule organizing center; and retromer complex.

Source: NCBI Gene 10807 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 147 total
• MANE Select transcript: NM_001039707

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10667
Approved symbol	ENTR1
Name	endosome associated trafficking regulator 1
Location	9q34.3
Locus type	gene with protein product
Status	Approved
Aliases	NY-CO-3
Ensembl gene	ENSG00000165689
Ensembl biotype	protein_coding
OMIM	618289
Entrez	10807

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 8 protein_coding, 5 protein_coding_CDS_not_defined

ENST00000298537, ENST00000357365, ENST00000371723, ENST00000371725, ENST00000417512, ENST00000446833, ENST00000461693, ENST00000466579, ENST00000468963, ENST00000481114, ENST00000486441, ENST00000918208, ENST00000918209

RefSeq mRNA: 3 — MANE Select: NM_001039707 NM_001039707, NM_001039708, NM_006643

CCDS: CCDS43903, CCDS43904, CCDS6999

Canonical transcript exons

ENST00000357365 — 10 exons

Exon	Start	End
ENSE00001433151	136408999	136409067
ENSE00001703364	136410090	136410239
ENSE00001791874	136405091	136405202
ENSE00001874161	136410328	136410614
ENSE00002167357	136407826	136407938
ENSE00003482816	136404631	136404693
ENSE00003595575	136404055	136404194
ENSE00003650270	136405905	136405978
ENSE00003717602	136401922	136402887
ENSE00003786326	136407145	136407561

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 96.08.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.7969 / max 238.3430, expressed in 1815 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
103155	15.4388	1795
103156	12.2692	1782
103154	0.0890	35

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	96.08	gold quality
right testis	UBERON:0004534	96.00	gold quality
right lobe of liver	UBERON:0001114	95.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.28	gold quality
right ovary	UBERON:0002118	95.16	gold quality
right lobe of thyroid gland	UBERON:0001119	95.08	gold quality
body of pancreas	UBERON:0001150	95.03	gold quality
granulocyte	CL:0000094	95.01	gold quality
cerebellar hemisphere	UBERON:0002245	94.88	gold quality
body of uterus	UBERON:0009853	94.78	gold quality
spleen	UBERON:0002106	94.75	gold quality
cerebellar cortex	UBERON:0002129	94.74	gold quality
endocervix	UBERON:0000458	94.72	gold quality
peripheral nervous system	UBERON:0000010	94.68	gold quality
nerve	UBERON:0001021	94.68	gold quality
tibial nerve	UBERON:0001323	94.68	gold quality
skin of abdomen	UBERON:0001416	94.61	gold quality
left ovary	UBERON:0002119	94.60	gold quality
lower esophagus mucosa	UBERON:0035834	94.54	gold quality
ectocervix	UBERON:0012249	94.53	gold quality
metanephros cortex	UBERON:0010533	94.49	gold quality
skin of leg	UBERON:0001511	94.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	94.19	gold quality
right uterine tube	UBERON:0001302	94.16	gold quality
left uterine tube	UBERON:0001303	94.15	gold quality
small intestine Peyer’s patch	UBERON:0003454	94.12	gold quality
lower esophagus	UBERON:0013473	94.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	94.08	gold quality
left lobe of thyroid gland	UBERON:0001120	94.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	93.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

23 targeting ENTR1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3148	99.97	75.06	6478
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-4760-5P	99.80	69.88	1619
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-561-3P	99.64	70.90	3647
HSA-MIR-217-5P	99.49	69.93	1419
HSA-MIR-766-5P	99.47	67.91	2225
HSA-MIR-122B-5P	99.46	70.81	1457
HSA-MIR-5582-5P	99.27	71.42	1879
HSA-MIR-6739-3P	99.22	68.84	1843
HSA-MIR-3199	99.17	65.19	696
HSA-MIR-8052	99.17	65.01	719
HSA-MIR-6807-3P	99.15	69.23	1275
HSA-MIR-140-3P	99.04	67.69	1324
HSA-MIR-6829-5P	98.86	65.12	1480
HSA-MIR-6776-5P	98.54	67.43	1304
HSA-MIR-892B	98.00	67.11	821
HSA-MIR-3670	97.88	64.39	763
HSA-MIR-514A-5P	96.94	65.49	801
HSA-MIR-6762-5P	96.55	64.62	972
HSA-MIR-6845-5P	96.55	64.65	969

Literature-anchored findings (GeneRIF, showing 4)

• SDCCAG3 is important for protein trafficking and presentation of TNFR1 on the cell surface. (PMID:16332174)
• The novel endosomal protein SDCCAG3 forms a complex with PTPN13 & interacts with GIT1. Interaction of SDCCAG3 with PTPN13 is mediated by the PTPN13 FERM domain & the SDCCAG3 N-terminus. SDCCAG3 expression levels are elevated in colon cancers. (PMID:23108400)
• SDCCAG3 has a role in ciliogenesis and in localization of cargo to primary cilia (PMID:27767179)
• Endosome associated trafficking regulator 1 promotes tumor growth and invasion of glioblastoma multiforme via inhibiting TNF signaling pathway. (PMID:38191954)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	entr1	ENSDARG00000095515
mus_musculus	Entr1	ENSMUSG00000026927
rattus_norvegicus	Entr1l3	ENSRNOG00000018876
rattus_norvegicus		ENSRNOG00000083656
rattus_norvegicus		ENSRNOG00000085394

Protein

Protein identifiers

Endosome-associated-trafficking regulator 1 — Q96C92 (reviewed: Q96C92)

Alternative names: Antigen NY-CO-3, Serologically defined colon cancer antigen 3

All UniProt accessions (4): Q96C92, A0A0A0MRP9, B5MDD7, H7C331

UniProt curated annotations — full annotation on UniProt →

Function. Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1. Plays a role in the formation of cilia. Involved in cargo protein localization, such as PKD2, at primary cilia. Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis.

Subunit / interactions. Found in a complex with ENTR1, PTPN13 and GIT1. Interacts with PTPN13 (via the FERM domain). Interacts (via N-terminus) with GIT1 (via N- and C-terminus); this interaction is direct. Interacts with NOD2. Interacts (via N-terminus) with IFT88. Interacts with VPS35.

Subcellular location. Cytoplasm. Early endosome. Endosome. Recycling endosome. Midbody. Cytoskeleton. Microtubule organizing center. Centrosome. Cilium basal body.

Tissue specificity. Expressed in the colon (at protein level).

Post-translational modifications. Phosphorylated.

Domain organisation. Tne N-terminal domain is necessary and sufficient for basal body localization and ciliogenesis.

Similarity. Belongs to the ENTR1 family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q96C92-1	1	yes
Q96C92-2	2
Q96C92-3	3
Q96C92-4	4

RefSeq proteins (3): NP_001034796, NP_001034797, NP_006634 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026757	ENTR1	Family

UniProt features (23 total): sequence variant 5, modified residue 4, region of interest 3, splice variant 3, mutagenesis site 2, sequence conflict 2, compositionally biased region 2, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96C92-F1	65.28	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 247, 18, 147, 243

Mutagenesis-validated functional residues (2):

Position	Phenotype
190	disrupts interaction with ptpn13.
194	disrupts interaction with ptpn13.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 157 (showing top): GOBP_PROTEIN_LOCALIZATION_TO_CILIUM, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, FOSTER_TOLERANT_MACROPHAGE_UP, GOBP_CYTOKINESIS, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_CILIUM_ORGANIZATION

GO Biological Process (7): protein transport (GO:0015031), cell projection organization (GO:0030030), endocytic recycling (GO:0032456), regulation of cytokinesis (GO:0032465), positive regulation of cilium assembly (GO:0045724), cell division (GO:0051301), positive regulation of protein localization to cilium (GO:1903566)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (10): endosome (GO:0005768), early endosome (GO:0005769), centrosome (GO:0005813), midbody (GO:0030496), ciliary basal body (GO:0036064), recycling endosome (GO:0055037), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), retromer complex (GO:0030904), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
endomembrane system	2
endosome	2
microtubule organizing center	2
transport	1
intracellular protein localization	1
establishment of protein localization	1
cellular component organization	1
endosomal transport	1
vesicle-mediated transport to the plasma membrane	1
cytokinesis	1
regulation of cell cycle process	1
regulation of cell division	1
cilium assembly	1
positive regulation of plasma membrane bounded cell projection assembly	1
regulation of cilium assembly	1
positive regulation of organelle assembly	1
cellular process	1
protein localization to cilium	1
regulation of protein localization to cilium	1
positive regulation of protein localization	1
binding	1
cytoplasmic vesicle	1
centriole	1
cilium	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
membrane protein complex	1

Protein interactions and networks

STRING

702 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ENTR1	PTPN13	Q12923	630
ENTR1	ANKRD27	Q96NW4	581
ENTR1	ANKRD50	Q9ULJ7	570
ENTR1	GPSM1	Q86YR5	565
ENTR1	CARD9	Q9H257	549
ENTR1	VPS26A	O75436	545
ENTR1	VPS26B	Q4G0F5	543
ENTR1	VPS29	Q9UBQ0	533
ENTR1	CENATAC	Q86UT8	528
ENTR1	NKX2-3	Q8TAU0	491
ENTR1	SLC9A4	Q6AI14	490
ENTR1	VPS35	Q96QK1	489
ENTR1	TMEM69	Q5SWH9	477
ENTR1	PTPN2	P17706	423
ENTR1	CCP110	O43303	423
ENTR1	SMC5	Q8IY18	423

IntAct

88 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
ODAD1	HGS	psi-mi:“MI:0914”(association)	0.850
IFT88	ENTR1	psi-mi:“MI:0915”(physical association)	0.600
ENTR1	IFT88	psi-mi:“MI:0403”(colocalization)	0.600
NOD2	ENTR1	psi-mi:“MI:0915”(physical association)	0.550
ENTR1	NOD2	psi-mi:“MI:0915”(physical association)	0.550
NOD2	ENTR1	psi-mi:“MI:2364”(proximity)	0.550
VPS35	ENTR1	psi-mi:“MI:0914”(association)	0.530
NUP62	RGPD8	psi-mi:“MI:0914”(association)	0.530
AURKA	WDR62	psi-mi:“MI:0914”(association)	0.530
HSPA8	ARHGEF10	psi-mi:“MI:2364”(proximity)	0.480
ENTR1	PKM	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
GSK3B	SEC16A	psi-mi:“MI:2364”(proximity)	0.420
ENTR1		psi-mi:“MI:0915”(physical association)	0.400
ENTR1	CSNK1E	psi-mi:“MI:0915”(physical association)	0.370
ENTR1	AP1M1	psi-mi:“MI:0915”(physical association)	0.370
OFD1	SUPT5H	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
WRAP73	AKAP8	psi-mi:“MI:0914”(association)	0.350
EGLN3	FAM168B	psi-mi:“MI:0914”(association)	0.350
ORF2	PRMT3	psi-mi:“MI:0914”(association)	0.350
TNIP2	TMEM178B	psi-mi:“MI:0914”(association)	0.350
VPS35	WASHC1	psi-mi:“MI:0914”(association)	0.350
VPS35	ILVBL	psi-mi:“MI:0914”(association)	0.350

BioGRID (250): SDCCAG3 (Two-hybrid), SDCCAG3 (Two-hybrid), SDCCAG3 (Two-hybrid), TFPT (Two-hybrid), SDCCAG3 (Affinity Capture-MS), SDCCAG3 (Affinity Capture-MS), SDCCAG3 (Proximity Label-MS), SDCCAG3 (Proximity Label-MS), SDCCAG3 (Proximity Label-MS), SDCCAG3 (Affinity Capture-MS), SDCCAG3 (Proximity Label-MS), SDCCAG3 (Proximity Label-MS), SDCCAG3 (Proximity Label-MS), SDCCAG3 (Proximity Label-MS), SDCCAG3 (Proximity Label-MS)

ESM2 similar proteins: A0FKI7, A2AHC3, A2AIW0, A4IH95, A5WUN7, A5WV69, A6H5Y1, A8MW92, D3Z8E6, P07106, P28290, P59598, Q08AD1, Q12912, Q2PFD7, Q3KQW7, Q4KLH6, Q4V9H5, Q502L1, Q52KN3, Q5R7V3, Q5REF4, Q5RHB5, Q5RJ80, Q5T5Y3, Q5T8D3, Q5XG73, Q5XI67, Q5ZHQ6, Q60664, Q640L3, Q640U0, Q641E3, Q6IRN6, Q6NPP4, Q6NRK3, Q6ZVD7, Q70EL1, Q76N89, Q8IX21

Diamond homologs: A2AIW0, A2CE83, Q28GJ0, Q2KJD6, Q54MB1, Q96C92

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
SMURF1	unknown	ENTR1	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 97 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
AURKA Activation by TPX2	11	26.2×	5e-11
Loss of Nlp from mitotic centrosomes	10	24.8×	5e-10
Loss of proteins required for interphase microtubule organization from the centrosome	10	24.8×	5e-10
Anchoring of the basal body to the plasma membrane	13	23.0×	3e-12
Regulation of PLK1 Activity at G2/M Transition	11	21.8×	3e-10
Recruitment of mitotic centrosome proteins and complexes	10	21.2×	2e-09
Recruitment of NuMA to mitotic centrosomes	10	18.2×	8e-09

GO biological processes:

GO term	Partners	Fold	FDR
centrosome duplication	5	53.2×	5e-06
centriole replication	6	50.0×	1e-06
non-motile cilium assembly	6	19.8×	8e-05
centrosome cycle	5	19.1×	5e-04
mitotic spindle organization	5	15.4×	9e-04
cilium assembly	11	9.2×	5e-06
intracellular protein localization	6	7.1×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

147 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	112
Likely benign	4
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1935 predictions. Top by Δscore:

Variant	Effect	Δscore
9:136404048:CACT:C	donor_loss	1.0000
9:136404052:CACT:C	donor_loss	1.0000
9:136404053:A:AC	donor_gain	1.0000
9:136404054:C:CC	donor_gain	1.0000
9:136404054:CTTG:C	donor_gain	1.0000
9:136404083:C:CT	donor_gain	1.0000
9:136404192:CGC:C	acceptor_gain	1.0000
9:136404195:C:CC	acceptor_gain	1.0000
9:136404619:T:TA	donor_gain	1.0000
9:136405035:T:A	donor_gain	1.0000
9:136405061:G:C	donor_gain	1.0000
9:136405066:T:TA	donor_gain	1.0000
9:136405089:A:AC	donor_gain	1.0000
9:136405090:C:CC	donor_gain	1.0000
9:136405090:CGGT:C	donor_gain	1.0000
9:136405199:CACC:C	acceptor_gain	1.0000
9:136405200:ACC:A	acceptor_gain	1.0000
9:136405201:CC:C	acceptor_gain	1.0000
9:136405201:CCC:C	acceptor_gain	1.0000
9:136405202:CC:C	acceptor_gain	1.0000
9:136405202:CCT:C	acceptor_loss	1.0000
9:136405203:C:CC	acceptor_gain	1.0000
9:136405203:C:T	acceptor_gain	1.0000
9:136405204:T:C	acceptor_gain	1.0000
9:136405204:T:TC	acceptor_gain	1.0000
9:136405207:T:C	acceptor_gain	1.0000
9:136405207:T:TC	acceptor_gain	1.0000
9:136405899:A:AC	donor_gain	1.0000
9:136405900:C:CC	donor_gain	1.0000
9:136405900:CATA:C	donor_gain	1.0000

AlphaMissense

2834 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:136404687:C:G	A338P	0.994
9:136404678:C:G	A341P	0.993
9:136405104:A:G	L331P	0.993
9:136402840:A:G	L419P	0.990
9:136405956:A:G	L281P	0.990
9:136404091:A:G	L391P	0.988
9:136404656:A:G	L348P	0.987
9:136405094:C:A	M334I	0.985
9:136405094:C:G	M334I	0.985
9:136405094:C:T	M334I	0.985
9:136407901:G:C	F109L	0.984
9:136407901:G:T	F109L	0.984
9:136407903:A:G	F109L	0.984
9:136405944:A:G	L285P	0.982
9:136402835:A:G	S421P	0.981
9:136402882:A:G	L405P	0.980
9:136405191:A:G	L302P	0.980
9:136404686:G:T	A338D	0.979
9:136404689:C:G	R337P	0.978
9:136407886:A:C	F114L	0.978
9:136407886:A:T	F114L	0.978
9:136407888:A:G	F114L	0.978
9:136402840:A:T	L419H	0.975
9:136405125:A:T	V324D	0.975
9:136405977:A:G	L274P	0.975
9:136407895:A:C	F111L	0.975
9:136407895:A:T	F111L	0.975
9:136407897:A:G	F111L	0.975
9:136404635:A:G	L355P	0.973
9:136405185:C:G	R304P	0.971

dbSNP variants (sampled 300 via entrez): RS1000280431 (9:136412300 C>A,T), RS1000479449 (9:136412286 A>G), RS1000840705 (9:136408835 G>A), RS1001086175 (9:136405253 G>A), RS1001131871 (9:136411208 C>G,T), RS1001140211 (9:136405464 G>A), RS1001356846 (9:136408977 A>G), RS1001711887 (9:136405219 C>A,T), RS1002343741 (9:136408654 T>C), RS1002711292 (9:136411608 G>A), RS1003093233 (9:136408710 G>A), RS1003099807 (9:136407072 T>C), RS1003144289 (9:136408823 T>C), RS1003309045 (9:136405638 A>G), RS1003489624 (9:136407933 T>C)

Disease associations

OMIM: gene MIM:618289 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST000964_39	Ulcerative colitis	3.000000e-19
GCST001725_102	Inflammatory bowel disease	4.000000e-56
GCST004131_21	Inflammatory bowel disease	5.000000e-36
GCST004132_11	Crohn’s disease	6.000000e-30
GCST004133_17	Ulcerative colitis	2.000000e-16
GCST008643_2	Joint damage in rheumatoid arthritis	1.000000e-06
GCST90020028_33	Hip circumference adjusted for BMI	4.000000e-08
GCST90020028_34	Hip circumference adjusted for BMI	5.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005413	joint damage measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
cobaltous chloride	decreases expression	2
Acetaminophen	increases expression, affects response to substance	2
Valproic Acid	decreases expression, increases methylation	2
Cadmium Chloride	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
FR900359	decreases phosphorylation	1
bufotalin	decreases expression	1
sodium arsenite	decreases expression	1
coumarin	decreases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Vehicle Emissions	decreases expression, increases abundance	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Estradiol	increases expression	1
Hydrogen Peroxide	affects expression	1
Nickel	increases expression	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Metribolone	increases expression	1
Sodium Selenite	increases expression	1
Copper Sulfate	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.