EP300-AS1

Summary

EP300-AS1 (EP300 antisense RNA 1, HGNC:50504) is a long non-coding RNA gene on chromosome 22q13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50504
Approved symbol	EP300-AS1
Name	EP300 antisense RNA 1
Location	22q13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231993
Ensembl biotype	lncRNA
Entrez	101927279
RNAcentral	URS000075B03B — lncRNA, 1405 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 28 lncRNA

ENST00000415054, ENST00000420537, ENST00000700839, ENST00000717629, ENST00000717630, ENST00000717631, ENST00000717632, ENST00000717633, ENST00000717634, ENST00000774286, ENST00000774287, ENST00000774288, ENST00000774289, ENST00000774290, ENST00000774291, ENST00000774292, ENST00000774293, ENST00000774294, ENST00000774295, ENST00000774296, ENST00000774297, ENST00000774298, ENST00000774299, ENST00000774300, ENST00000774301, ENST00000774302, ENST00000774303, ENST00000774304

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415054 — 3 exons

Exon	Start	End
ENSE00001779961	41169190	41169404
ENSE00004032994	41169522	41169581
ENSE00004032998	41183063	41183144

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 88.20.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5205 / max 21.2010, expressed in 291 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194342	0.3268	163
194341	0.1937	78

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.20	gold quality
bone marrow	UBERON:0002371	83.87	gold quality
monocyte	CL:0000576	82.18	gold quality
leukocyte	CL:0000738	81.11	gold quality
endometrium	UBERON:0001295	76.90	gold quality
mucosa of stomach	UBERON:0001199	75.40	gold quality
rectum	UBERON:0001052	74.63	gold quality
left testis	UBERON:0004533	73.36	gold quality
testis	UBERON:0000473	73.12	gold quality
right testis	UBERON:0004534	73.12	gold quality
granulocyte	CL:0000094	72.44	gold quality
right uterine tube	UBERON:0001302	72.35	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.72	gold quality
right lung	UBERON:0002167	71.15	gold quality
skin of abdomen	UBERON:0001416	70.94	gold quality
ganglionic eminence	UBERON:0004023	70.88	gold quality
duodenum	UBERON:0002114	70.84	gold quality
cortical plate	UBERON:0005343	70.72	gold quality
upper lobe of left lung	UBERON:0008952	70.63	gold quality
left uterine tube	UBERON:0001303	70.56	gold quality
zone of skin	UBERON:0000014	70.18	gold quality
gall bladder	UBERON:0002110	70.17	gold quality
urinary bladder	UBERON:0001255	70.13	gold quality
vermiform appendix	UBERON:0001154	69.98	gold quality
smooth muscle tissue	UBERON:0001135	69.79	gold quality
skin of leg	UBERON:0001511	69.73	gold quality
fallopian tube	UBERON:0003889	69.63	gold quality
esophagus mucosa	UBERON:0002469	69.38	gold quality
lymph node	UBERON:0000029	69.29	gold quality
lung	UBERON:0002048	69.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.68

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.