EPB41L4A-AS1

Summary

EPB41L4A-AS1 (EPB41L4A antisense RNA 1, HGNC:30749) is a long non-coding RNA gene on chromosome 5q22.1.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 114915 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30749
Approved symbol	EPB41L4A-AS1
Name	EPB41L4A antisense RNA 1
Location	5q22.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	EAS1, TIGA1
Ensembl gene	ENSG00000224032
Ensembl biotype	lncRNA
Entrez	114915
RNAcentral	URS000075CCBD — lncRNA, 1194 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000413221, ENST00000427306, ENST00000442823, ENST00000508590, ENST00000663232, ENST00000688370, ENST00000690733, ENST00000702181, ENST00000702686, ENST00000810489, ENST00000810490, ENST00000810491

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413221 — 3 exons

Exon	Start	End
ENSE00002086360	112162151	112164257
ENSE00003864704	112160872	112161295
ENSE00003878953	112161686	112161775

Expression profiles

Bgee: expression breadth ubiquitous, 235 present calls, max score 98.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 61.1012 / max 533.8358, expressed in 1819 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57987	58.9826	1819
57988	1.9888	999
57989	0.1297	44

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ovary	UBERON:0002119	98.53	gold quality
body of pancreas	UBERON:0001150	98.25	gold quality
calcaneal tendon	UBERON:0003701	98.06	gold quality
cortical plate	UBERON:0005343	97.83	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	97.80	gold quality
right ovary	UBERON:0002118	97.60	gold quality
mucosa of stomach	UBERON:0001199	97.41	gold quality
ganglionic eminence	UBERON:0004023	97.35	gold quality
cerebellar hemisphere	UBERON:0002245	97.25	gold quality
cerebellar cortex	UBERON:0002129	97.23	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.07	gold quality
skin of leg	UBERON:0001511	96.63	gold quality
skin of abdomen	UBERON:0001416	96.60	gold quality
endocervix	UBERON:0000458	96.39	gold quality
cerebellum	UBERON:0002037	96.33	gold quality
tendon	UBERON:0000043	96.26	gold quality
body of uterus	UBERON:0009853	96.06	gold quality
body of stomach	UBERON:0001161	96.01	gold quality
tibial artery	UBERON:0007610	95.94	gold quality
popliteal artery	UBERON:0002250	95.93	gold quality
ectocervix	UBERON:0012249	95.85	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.78	gold quality
tibial nerve	UBERON:0001323	95.40	gold quality
ventricular zone	UBERON:0003053	95.20	gold quality
anterior cingulate cortex	UBERON:0009835	95.14	gold quality
minor salivary gland	UBERON:0001830	95.11	gold quality
left uterine tube	UBERON:0001303	95.00	gold quality
muscle layer of sigmoid colon	UBERON:0035805	94.98	gold quality
right uterine tube	UBERON:0001302	94.89	gold quality
right frontal lobe	UBERON:0002810	94.87	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-10662	yes	1378.35
E-ANND-3	yes	8.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• vascular calcification-associated factor (VCAF) is present in human calcified arteries but not noncalcified arteries (PMID:15994437)
• EPB41L4A-AS1 functions as a repressor of the Warburg effect by mediating nucleolar translocation of HDAC2. (PMID:30796006)
• miR-146a interacting with lncRNA EPB41L4A-AS1 and lncRNA SNHG7 inhibits proliferation of bone marrow-derived mesenchymal stem cells. (PMID:31612476)
• Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer. (PMID:32557646)
• LncRNA EPB41L4A-AS1 Regulates Cell Proliferation, Apoptosis and Metastasis in Breast Cancer. (PMID:35181612)
• IncRNA EPB41L4A-AS1 Mitigates the Proliferation of Non-Small-Cell Lung Cancer Cells through the miR-105-5p/GIMAP6 Axis. (PMID:36734855)
• Elevated exosome-transferrable lncRNA EPB41L4A-AS1 in CD56[bright] NK cells is responsible for the impaired NK function in neuroblastoma patients by suppressing cell glycolysis. (PMID:37024023)
• Downregulation of lncRNA EPB41L4A-AS1 promotes gastric cancer cell proliferation, migration and invasion. (PMID:38627627)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.