EPB41L4A-DT

Summary

EPB41L4A-DT (EPB41L4A divergent transcript, HGNC:25643) is a long non-coding RNA gene on chromosome 5q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25643
Approved symbol	EPB41L4A-DT
Name	EPB41L4A divergent transcript
Location	5q22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ11235
Ensembl gene	ENSG00000278921
Ensembl biotype	lncRNA
Entrez	54508
RNAcentral	URS000075D180 — lncRNA, 1406 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000623705

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000623705 — 1 exons

Exon	Start	End
ENSE00003758643	112419583	112420978

Expression profiles

Bgee: expression breadth ubiquitous, 178 present calls, max score 82.96.

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.96	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.33	silver quality
cortical plate	UBERON:0005343	74.71	gold quality
ventricular zone	UBERON:0003053	73.27	gold quality
palpebral conjunctiva	UBERON:0001812	71.48	gold quality
esophagus squamous epithelium	UBERON:0006920	67.05	silver quality
ganglionic eminence	UBERON:0004023	66.64	gold quality
right lung	UBERON:0002167	66.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	65.95	gold quality
esophagus mucosa	UBERON:0002469	65.74	gold quality
right atrium auricular region	UBERON:0006631	65.56	gold quality
left lobe of thyroid gland	UBERON:0001120	65.03	gold quality
lower esophagus mucosa	UBERON:0035834	64.91	gold quality
metanephros cortex	UBERON:0010533	64.76	gold quality
epithelium of esophagus	UBERON:0001976	64.69	silver quality
omental fat pad	UBERON:0010414	64.65	gold quality
peritoneum	UBERON:0002358	64.58	gold quality
adipose tissue of abdominal region	UBERON:0007808	64.34	gold quality
cardiac atrium	UBERON:0002081	64.21	gold quality
right lobe of thyroid gland	UBERON:0001119	64.16	gold quality
pancreatic ductal cell	CL:0002079	64.12	silver quality
thyroid gland	UBERON:0002046	64.05	gold quality
apex of heart	UBERON:0002098	63.31	gold quality
thoracic aorta	UBERON:0001515	63.20	gold quality
right coronary artery	UBERON:0001625	63.16	gold quality
ascending aorta	UBERON:0001496	63.15	gold quality
descending thoracic aorta	UBERON:0002345	62.96	gold quality
left coronary artery	UBERON:0001626	62.95	gold quality
pigmented layer of retina	UBERON:0001782	62.82	gold quality
heart left ventricle	UBERON:0002084	62.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Low EPB41L4A-AS2 expression is associated with breast, renal, and lung cancer. (PMID:26980733)
• The relationship of EPB41L4A-AS2 with the clinicopathological features and prognosis of head and neck squamous cell carcinoma patients was evaluated. (PMID:29490660)
• FOXL1 and miR-301a-5p show opposite biological effects in cell proliferation and migration. miR-301a-5p overexpression rescued the EPB41L4A-AS2 upregulation induced depression in proliferation, migration and invasion of HCC cells, as well as promotion effect on FOXL1 expression. In vivo experiments proved that EPB41L4A-AS2 suppress tumor growth and extrahepatic metastasis (lung) via the miR-301a-5p-FOXL1 axis. (PMID:30971290)
• Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1. (PMID:31645082)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.