EPC2

Summary

EPC2 (enhancer of polycomb 2, HGNC:24543) is a protein-coding gene on chromosome 2q23.1, encoding Enhancer of polycomb homolog 2 (Q52LR7). May play a role in transcription or DNA repair. It is a selective cancer dependency (DepMap: 27.2% of cell lines).

Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Part of NuA4 histone acetyltransferase complex and nucleosome.

Source: NCBI Gene 26122 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 103 total — 4 pathogenic, 2 likely-pathogenic
• Cancer dependency (DepMap): dependent in 27.2% of screened cell lines
• MANE Select transcript: NM_015630

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24543
Approved symbol	EPC2
Name	enhancer of polycomb 2
Location	2q23.1
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP566F2124
Ensembl gene	ENSG00000135999
Ensembl biotype	protein_coding
OMIM	611000
Entrez	26122

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 retained_intron

ENST00000258484, ENST00000397424, ENST00000409654, ENST00000449013, ENST00000457184, ENST00000491099, ENST00000902236, ENST00000902237

RefSeq mRNA: 1 — MANE Select: NM_015630 NM_015630

CCDS: CCDS46422

Canonical transcript exons

ENST00000258484 — 14 exons

Exon	Start	End
ENSE00001153925	148786305	148787569
ENSE00001153931	148743622	148743767
ENSE00001689981	148644751	148645170
ENSE00001758796	148753927	148754133
ENSE00003595825	148690214	148690373
ENSE00004282159	148784668	148785001
ENSE00004282160	148764955	148765146
ENSE00004282161	148781644	148781780
ENSE00004282162	148769151	148769240
ENSE00004282163	148761782	148761930
ENSE00004282164	148783597	148783756
ENSE00004282165	148762670	148762802
ENSE00004282166	148771044	148771387
ENSE00004282167	148770792	148770937

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 95.73.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.2969 / max 669.3664, expressed in 1811 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
22957	22.2969	1811

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
germinal epithelium of ovary	UBERON:0001304	95.73	gold quality
calcaneal tendon	UBERON:0003701	95.44	gold quality
ganglionic eminence	UBERON:0004023	94.44	gold quality
ventricular zone	UBERON:0003053	93.98	gold quality
cortical plate	UBERON:0005343	93.74	gold quality
endothelial cell	CL:0000115	93.20	silver quality
sural nerve	UBERON:0015488	93.20	gold quality
bone marrow cell	CL:0002092	91.63	gold quality
tendon	UBERON:0000043	91.37	gold quality
corpus callosum	UBERON:0002336	91.19	gold quality
amniotic fluid	UBERON:0000173	90.45	gold quality
monocyte	CL:0000576	89.98	gold quality
ovary	UBERON:0000992	89.79	gold quality
thymus	UBERON:0002370	89.79	gold quality
leukocyte	CL:0000738	89.69	gold quality
gingival epithelium	UBERON:0001949	89.68	silver quality
left ovary	UBERON:0002119	89.63	gold quality
middle temporal gyrus	UBERON:0002771	89.56	gold quality
smooth muscle tissue	UBERON:0001135	89.02	gold quality
visceral pleura	UBERON:0002401	88.99	gold quality
parietal pleura	UBERON:0002400	88.86	gold quality
superficial temporal artery	UBERON:0001614	88.83	gold quality
bone marrow	UBERON:0002371	88.77	gold quality
right ovary	UBERON:0002118	88.69	gold quality
Brodmann (1909) area 23	UBERON:0013554	88.52	gold quality
urethra	UBERON:0000057	88.50	gold quality
popliteal artery	UBERON:0002250	88.36	gold quality
pericardium	UBERON:0002407	88.35	gold quality
tibial artery	UBERON:0007610	88.35	gold quality
saphenous vein	UBERON:0007318	88.34	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.44
E-HCAD-5	no	2.22

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

177 targeting EPC2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 27.2% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• EPC1 and EPC2 are components of a complex that directly or indirectly serves to prevent MYC accumulation and AML cell apoptosis, thus sustaining oncogenic potential (PMID:24166297)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	epc2	ENSDARG00000007485
mus_musculus	Epc2	ENSMUSG00000069495
rattus_norvegicus	Epc2	ENSRNOG00000029447
rattus_norvegicus	AC142154.1	ENSRNOG00000050758
drosophila_melanogaster	E(Pc)	FBGN0000581
caenorhabditis_elegans		WBGENE00007030

Paralogs (1): EPC1 (ENSG00000120616)

Protein

Protein identifiers

Enhancer of polycomb homolog 2 — Q52LR7 (reviewed: Q52LR7)

Alternative names: EPC-like

All UniProt accessions (5): C9J1X4, E7ETK1, E9PBA8, Q52LR7, H7C0K5

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in transcription or DNA repair.

Subcellular location. Nucleus.

Similarity. Belongs to the enhancer of polycomb family.

RefSeq proteins (1): NP_056445* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009607	Enhancer_polycomb_C	Domain
IPR019542	Enhancer_polycomb-like_N	Domain
IPR024943	Enhancer_polycomb	Family

Pfam: PF06752, PF10513

UniProt features (14 total): cross-link 4, region of interest 3, compositionally biased region 3, modified residue 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q52LR7-F1	58.35	0.15

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 195, 324, 362, 538, 754, 135

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 239 (showing top): GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR, WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN, GOBP_REGULATION_OF_DNA_RECOMBINATION, ACTACCT_MIR196A_MIR196B, GCM_GSPT1, TGCACTT_MIR519C_MIR519B_MIR519A, GCM_ZNF198, GTTAAAG_MIR302B, TGACCTY_ERR1_Q2, GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION, CHANDRAN_METASTASIS_DN, GOBP_REGULATION_OF_DNA_REPAIR, ATGTTAA_MIR302C, CTAGGAA_MIR384, CATTTCA_MIR203

GO Biological Process (9): DNA repair (GO:0006281), chromatin organization (GO:0006325), regulation of transcription by RNA polymerase II (GO:0006357), regulation of apoptotic process (GO:0042981), positive regulation of DNA-templated transcription (GO:0045893), regulation of cell cycle (GO:0051726), positive regulation of double-strand break repair via homologous recombination (GO:1905168), regulation of double-strand break repair (GO:2000779), DNA damage response (GO:0006974)

GO Molecular Function (0):

GO Cellular Component (5): nucleosome (GO:0000786), nucleus (GO:0005634), piccolo histone acetyltransferase complex (GO:0032777), NuA4 histone acetyltransferase complex (GO:0035267), histone acetyltransferase complex (GO:0000123)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
chromatin	2
DNA metabolic process	1
DNA damage response	1
cellular component organization	1
transcription by RNA polymerase II	1
apoptotic process	1
regulation of programmed cell death	1
DNA-templated transcription	1
positive regulation of RNA biosynthetic process	1
cell cycle	1
regulation of cellular process	1
double-strand break repair via homologous recombination	1
regulation of double-strand break repair via homologous recombination	1
positive regulation of DNA recombination	1
positive regulation of double-strand break repair	1
regulation of DNA repair	1
double-strand break repair	1
cellular response to stress	1
protein-DNA complex	1
intracellular membrane-bounded organelle	1
protein-containing complex	1
H4/H2A histone acetyltransferase complex	1
protein acetyltransferase complex	1

Protein interactions and networks

STRING

1442 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EPC2	DMAP1	Q9NPF5	898
EPC2	BRD8	Q9H0E9	860
EPC2	MEAF6	Q9HAF1	838
EPC2	EZH2	Q15910	832
EPC2	TRRAP	Q9Y4A5	788
EPC2	ING3	Q9NXR8	778
EPC2	ACTL6A	O96019	716
EPC2	MORF4L1	Q9UBU8	695
EPC2	MRGBP	Q9NV56	650
EPC2	MBTD1	Q05BQ5	633
EPC2	YEATS4	O95619	618
EPC2	EP400	Q96L91	566
EPC2	CAPN14	A8MX76	557
EPC2	RUVBL1	P82276	551
EPC2	KAT5	Q92993	545

IntAct

117 interactions, top by confidence:

A	B	Type	Score
RUVBL1	ZNHIT1	psi-mi:“MI:0914”(association)	0.860
MRGBP	YEATS4	psi-mi:“MI:0914”(association)	0.840
RUVBL2	ZNHIT1	psi-mi:“MI:0914”(association)	0.810
YEATS4	ZNHIT1	psi-mi:“MI:0914”(association)	0.790
H2AZ1	ZNHIT1	psi-mi:“MI:0914”(association)	0.770
MED23	MED19	psi-mi:“MI:2364”(proximity)	0.770
TRRAP	ATXN7	psi-mi:“MI:0914”(association)	0.740
MBTD1	YEATS4	psi-mi:“MI:0914”(association)	0.730
MORF4L1	SIN3B	psi-mi:“MI:0914”(association)	0.730
ACTL6A	ZNHIT1	psi-mi:“MI:0914”(association)	0.720
VPS72	ZNHIT1	psi-mi:“MI:0914”(association)	0.690
H2BC1	PPM1G	psi-mi:“MI:0914”(association)	0.640
RUVBL2	POLR3A	psi-mi:“MI:0914”(association)	0.640
RUVBL1	POLR3A	psi-mi:“MI:0914”(association)	0.640
MORF4L2	YEATS4	psi-mi:“MI:0914”(association)	0.640
FOXR1	YEATS4	psi-mi:“MI:0914”(association)	0.640
KPNA1	TCERG1	psi-mi:“MI:0914”(association)	0.640
EPC2	YEATS4	psi-mi:“MI:0914”(association)	0.640

BioGRID (124): EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Proximity Label-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS), EPC2 (Affinity Capture-MS)

ESM2 similar proteins: A3LYI0, A5DLJ8, A5JYW9, A8WSQ9, C5DX31, G4NID8, G5ED89, O14174, O74365, P0C5E6, P0CN58, P0CN59, P18480, P22579, P25644, P32257, P34333, P39927, P50875, P52654, Q06337, Q07684, Q09345, Q09750, Q177A7, Q20374, Q23523, Q23590, Q4VYR7, Q52LR7, Q58NQ4, Q5A2B9, Q5W1J5, Q61X54, Q621Z7, Q66JA8, Q6C7K8, Q6CIN8, Q6CMB8, Q6DJR9

Diamond homologs: P0CN58, P0CN59, Q52LR7, Q5AYR3, Q66JA8, Q6CEV5, Q6DJR9, Q8C0I4, Q9UU94, P43572, Q4I5V3, Q4WDF1, Q6CIN8, Q6FLZ0, Q752Q3, Q7S747, Q8C9X6, Q9H2F5, Q5AAG1, Q6BNX0

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
EPC2	“form complex”	“NuA4 complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 108 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
HATs acetylate histones	19	20.4×	1e-17
Chromatin organization	13	14.3×	1e-09
Deposition of new CENPA-containing nucleosomes at the centromere	6	12.9×	5e-04
Chromatin modifying enzymes	13	12.7×	3e-09
Formation of the beta-catenin:TCF transactivating complex	7	11.4×	3e-04
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	5	9.9×	7e-03
mRNA Polyadenylation	6	7.1×	8e-03
Processing of Capped Intron-Containing Pre-mRNA	6	6.7×	1e-02

GO biological processes:

GO term	Partners	Fold	FDR
regulation of double-strand break repair	14	79.8×	1e-21
positive regulation of double-strand break repair via homologous recombination	15	56.3×	1e-20
regulation of DNA replication	7	25.1×	9e-07
regulation of DNA repair	7	19.0×	6e-06
cellular response to UV	5	14.5×	1e-03
regulation of apoptotic process	17	13.9×	8e-13
positive regulation of transcription initiation by RNA polymerase II	5	13.3×	2e-03
regulation of cell cycle	16	11.7×	6e-11

Disease & clinical

Clinical variants and AI predictions

ClinVar

103 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	4
Likely pathogenic	2
Uncertain significance	80
Likely benign	0
Benign	5

Top pathogenic / likely-pathogenic (6)

Variant ID	HGVS	Classification
150817	GRCh38/hg38 2q23.1-23.2(chr2:148440874-149091788)x1	Pathogenic
183383	NC_000002.10:g.148447496_149377297del	Pathogenic
395440	GRCh37/hg19 2q23.1-23.3(chr2:148842506-152370040)x1	Pathogenic
403692	Single allele	Pathogenic
2506556	GRCh37/hg19 2q23.1(chr2:149220152-149633312)	Likely pathogenic
562615	GRCh37/hg19 2q23.1(chr2:148704099-149545055)x3	Likely pathogenic

SpliceAI

2368 predictions. Top by Δscore:

Variant	Effect	Δscore
2:148645159:G:GT	donor_gain	1.0000
2:148645162:G:GT	donor_gain	1.0000
2:148645167:ATCGG:A	donor_loss	1.0000
2:148645168:TCGG:T	donor_loss	1.0000
2:148645171:G:GG	donor_gain	1.0000
2:148645172:T:A	donor_loss	1.0000
2:148690203:A:AG	acceptor_gain	1.0000
2:148690205:A:AG	acceptor_gain	1.0000
2:148690206:T:G	acceptor_gain	1.0000
2:148690212:A:AG	acceptor_gain	1.0000
2:148690212:AG:A	acceptor_gain	1.0000
2:148690213:G:A	acceptor_loss	1.0000
2:148690213:G:GA	acceptor_gain	1.0000
2:148690213:GG:G	acceptor_gain	1.0000
2:148690213:GGA:G	acceptor_gain	1.0000
2:148690213:GGAA:G	acceptor_gain	1.0000
2:148690213:GGAAC:G	acceptor_gain	1.0000
2:148690336:A:T	donor_gain	1.0000
2:148690369:TCAGC:T	donor_gain	1.0000
2:148690370:CAGC:C	donor_gain	1.0000
2:148690371:AGC:A	donor_gain	1.0000
2:148690372:GC:G	donor_gain	1.0000
2:148690372:GCG:G	donor_gain	1.0000
2:148690374:G:GG	donor_gain	1.0000
2:148690374:GTAA:G	donor_loss	1.0000
2:148690375:T:TC	donor_loss	1.0000
2:148690378:G:GG	donor_gain	1.0000
2:148743620:A:AG	acceptor_gain	1.0000
2:148743621:G:A	acceptor_loss	1.0000
2:148743621:G:GA	acceptor_gain	1.0000

AlphaMissense

5334 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:148645033:T:C	F6L	1.000
2:148645034:T:C	F6S	1.000
2:148645034:T:G	F6C	1.000
2:148645035:C:A	F6L	1.000
2:148645035:C:G	F6L	1.000
2:148645036:C:G	R7G	1.000
2:148645037:G:A	R7Q	1.000
2:148645049:T:A	L11Q	1.000
2:148645051:G:C	D12H	1.000
2:148645067:T:C	L17P	1.000
2:148645124:G:C	R36P	1.000
2:148645130:T:A	V38E	1.000
2:148645139:T:C	M41T	1.000
2:148645139:T:G	M41R	1.000
2:148645142:C:A	P42H	1.000
2:148645145:C:T	T43I	1.000
2:148645147:G:A	G44R	1.000
2:148645147:G:C	G44R	1.000
2:148645147:G:T	G44W	1.000
2:148645148:G:A	G44E	1.000
2:148645151:T:A	M45K	1.000
2:148645151:T:C	M45T	1.000
2:148645151:T:G	M45R	1.000
2:148645152:G:A	M45I	1.000
2:148645152:G:C	M45I	1.000
2:148645152:G:T	M45I	1.000
2:148645162:G:A	E49K	1.000
2:148645164:G:C	E49D	1.000
2:148645164:G:T	E49D	1.000
2:148690216:A:C	E52D	1.000

dbSNP variants (sampled 300 via entrez): RS1000010253 (2:148750373 A>G), RS1000022907 (2:148710093 A>C), RS1000056117 (2:148662009 T>C), RS1000080929 (2:148700934 T>A,G), RS1000100366 (2:148671473 G>T), RS1000100970 (2:148657143 T>G), RS1000122373 (2:148712492 A>G), RS1000122556 (2:148783958 C>T), RS1000125016 (2:148715148 C>G), RS1000159075 (2:148717275 A>G), RS1000181493 (2:148764117 A>G), RS1000184935 (2:148648032 C>T), RS1000207971 (2:148717446 G>T), RS1000275882 (2:148724258 C>G), RS1000292709 (2:148689066 A>T)

Disease associations

OMIM: gene MIM:611000 | disease phenotypes: MIM:156200

GenCC curated gene-disease

Mondo (1): intellectual disability, autosomal dominant 1 (MONDO:0007974)

Orphanet (1): 2q23.1 microdeletion syndrome (Orphanet:228402)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST000189_10	Protein quantitative trait loci	4.000000e-06
GCST000900_1	Alzheimer’s disease biomarkers	1.000000e-06
GCST000900_4	Alzheimer’s disease biomarkers	1.000000e-06
GCST006397_6	Relative amplitude of rest-activity cycles	3.000000e-06
GCST006803_46	Schizophrenia	8.000000e-07
GCST007201_29	Schizophrenia	8.000000e-09
GCST007272_35	Pulse pressure	3.000000e-25
GCST007272_39	Pulse pressure	6.000000e-24
GCST007576_44	Chronotype	2.000000e-09
GCST007847_107	Type 2 diabetes	5.000000e-09
GCST009391_1617	Metabolite levels	9.000000e-06
GCST010118_16	Type 2 diabetes	1.000000e-09

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004811	interleukin-8 measurement
EFO:0004760	t-tau measurement
EFO:0004670	beta-amyloid 1-42 measurement
EFO:0005763	pulse pressure measurement
EFO:0008328	chronotype measurement
EFO:0010378	phosphatidylcholine 34:4 measurement

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C566947	Mental Retardation, Autosomal Dominant 1 (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, affects expression	5
trichostatin A	decreases expression, affects expression, affects cotreatment	3
sodium arsenite	decreases expression	2
Formaldehyde	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
TAK-243	decreases sumoylation	1
TL8-506	affects cotreatment, increases expression	1
propionaldehyde	decreases expression	1
arsenite	affects binding, decreases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
entinostat	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
Sunitinib	increases expression	1
Vorinostat	decreases expression	1
Leflunomide	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Amiodarone	increases expression	1
Arsenic	affects methylation	1
Caffeine	affects phosphorylation	1
Dimethyl Sulfoxide	increases expression	1
Doxorubicin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Testosterone	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.