EPCART

Summary

EPCART (ERG-positive prostate cancer associated androgen responsive transcript, HGNC:51792) is a long non-coding RNA gene on chromosome 2q31.3.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51792
Approved symbol	EPCART
Name	ERG-positive prostate cancer associated androgen responsive transcript
Location	2q31.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	TPCAT-2-180961, PRCAT122, PCAT-2-180961
Entrez	105373767

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer. (PMID:39147845)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000109961 (2:180124248 C>G), RS1000626523 (2:180120503 T>C), RS1000767241 (2:180126578 A>G), RS1001012590 (2:180124978 C>G,T), RS1001099067 (2:180125399 A>C), RS1001100083 (2:180119240 G>A), RS1001377271 (2:180118865 A>G), RS1001624454 (2:180124540 C>G), RS1002072397 (2:180121471 T>A,C), RS1002140302 (2:180122757 G>A,C,T), RS1002229940 (2:180127194 G>A), RS1002446935 (2:180120198 T>C), RS1002526719 (2:180121192 G>A), RS1002590581 (2:180118195 T>C), RS1002739953 (2:180124268 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.