EPIC1

Summary

EPIC1 (epigenetically induced MYC interacting lncRNA 1, HGNC:27672) is a long non-coding RNA gene on chromosome 22q13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27672
Approved symbol	EPIC1
Name	epigenetically induced MYC interacting lncRNA 1
Location	22q13.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	Lnc-EPIC1
Ensembl gene	ENSG00000224271
Ensembl biotype	lncRNA
Entrez	284930
RNAcentral	URS00002B0998 — lncRNA, 1815 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 80 — 80 lncRNA

ENST00000423737, ENST00000426452, ENST00000438810, ENST00000449941, ENST00000650660, ENST00000650683, ENST00000650749, ENST00000650775, ENST00000650787, ENST00000650834, ENST00000650884, ENST00000650895, ENST00000650924, ENST00000650947, ENST00000650972, ENST00000651003, ENST00000651033, ENST00000651037, ENST00000651056, ENST00000651071, ENST00000651104, ENST00000651124, ENST00000651270, ENST00000651293, ENST00000651294, ENST00000651308, ENST00000651311, ENST00000651381, ENST00000651394, ENST00000651403, ENST00000651445, ENST00000651458, ENST00000651517, ENST00000651536, ENST00000651538, ENST00000651584, ENST00000651625, ENST00000651637, ENST00000651638, ENST00000651662, ENST00000651754, ENST00000651884, ENST00000651924, ENST00000651938, ENST00000651939, ENST00000651948, ENST00000651983, ENST00000651985, ENST00000652030, ENST00000652072, ENST00000652080, ENST00000652123, ENST00000652164, ENST00000652168, ENST00000652206, ENST00000652228, ENST00000652334, ENST00000652399, ENST00000652442, ENST00000652499, ENST00000652505, ENST00000652597, ENST00000652611, ENST00000652656, ENST00000652675, ENST00000652690, ENST00000652702, ENST00000652750, ENST00000664761, ENST00000665418, ENST00000670853, ENST00000670886, ENST00000701491, ENST00000809073, ENST00000809074, ENST00000809075, ENST00000809076, ENST00000809077, ENST00000809078, ENST00000809079

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423737 — 9 exons

Exon	Start	End
ENSE00001634581	47686575	47686695
ENSE00001700045	47687141	47687206
ENSE00001704847	47631674	47631886
ENSE00001707217	47686200	47686312
ENSE00001712060	47704589	47704747
ENSE00001744361	47686803	47686938
ENSE00001773563	47854911	47855600
ENSE00001778151	47635180	47635353
ENSE00001797469	47738434	47738576

Expression profiles

Bgee: expression breadth ubiquitous, 138 present calls, max score 88.89.

Top tissues by expression

219 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.89	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.65	gold quality
endothelial cell	CL:0000115	80.46	gold quality
buccal mucosa cell	CL:0002336	79.88	gold quality
skin of leg	UBERON:0001511	76.64	gold quality
bone marrow cell	CL:0002092	76.26	gold quality
skin of abdomen	UBERON:0001416	75.92	gold quality
zone of skin	UBERON:0000014	74.03	gold quality
oocyte	CL:0000023	71.86	silver quality
primary visual cortex	UBERON:0002436	69.90	gold quality
parotid gland	UBERON:0001831	69.88	gold quality
colonic epithelium	UBERON:0000397	69.54	silver quality
sural nerve	UBERON:0015488	69.50	gold quality
mucosa of paranasal sinus	UBERON:0005030	68.31	gold quality
right frontal lobe	UBERON:0002810	68.29	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	67.95	gold quality
superficial temporal artery	UBERON:0001614	67.93	gold quality
prefrontal cortex	UBERON:0000451	67.70	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.98	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.82	gold quality
occipital lobe	UBERON:0002021	66.01	gold quality
secondary oocyte	CL:0000655	65.74	gold quality
frontal cortex	UBERON:0001870	65.66	gold quality
myocardium	UBERON:0002349	64.74	gold quality
vastus lateralis	UBERON:0001379	64.49	gold quality
Brodmann (1909) area 23	UBERON:0013554	64.39	silver quality
neocortex	UBERON:0001950	64.33	gold quality
quadriceps femoris	UBERON:0001377	64.23	gold quality
epithelium of nasopharynx	UBERON:0001951	63.45	gold quality
upper leg skin	UBERON:0004262	63.37	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Study observed a recurrent hypomethylation of 1,006 lncRNA genes in cancer, including EPIC1 (epigenetically-induced lncRNA1). Overexpression of EPIC1 is associated with poor prognosis in luminal B breast cancer patients and enhances tumor growth in vitro and in vivo. Mechanistically, EPIC1 promotes cell-cycle progression by interacting with MYC through EPIC1’s 129-283 nt region. (PMID:29622465)
• Long non-coding RNA EPIC1 inhibits viability and invasion of osteosarcoma cells by promoting MEF2D ubiquitylation (PMID:30703420)
• LincRNA-immunity landscape analysis identifies EPIC1 as a regulator of tumor immune evasion and immunotherapy resistance. (PMID:33568470)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.