EPIST

Summary

EPIST (esophagus epithelial intergenic associated transcript, HGNC:49679) is a long non-coding RNA gene on chromosome 5q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49679
Approved symbol	EPIST
Name	esophagus epithelial intergenic associated transcript
Location	5q31.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	XLH-36, CTC-276P9.1, Epist
Ensembl gene	ENSG00000249082
Ensembl biotype	lncRNA
Entrez	101927953
RNAcentral	URS000075D1EE — lncRNA, 843 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000507035, ENST00000511256, ENST00000807101, ENST00000807102

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000507035 — 2 exons

Exon	Start	End
ENSE00002050021	135039596	135040047
ENSE00002054750	135038831	135039221

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 98.13.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.8898 / max 126.3518, expressed in 122 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
63517	0.7861	116
63516	0.1037	36

Top tissues by expression

203 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	98.13	gold quality
esophagus mucosa	UBERON:0002469	94.05	gold quality
pituitary gland	UBERON:0000007	88.90	gold quality
minor salivary gland	UBERON:0001830	87.08	gold quality
adenohypophysis	UBERON:0002196	86.87	gold quality
mouth mucosa	UBERON:0003729	86.45	gold quality
oral cavity	UBERON:0000167	86.01	gold quality
saliva-secreting gland	UBERON:0001044	85.65	gold quality
buccal mucosa cell	CL:0002336	85.30	gold quality
esophagus squamous epithelium	UBERON:0006920	84.13	gold quality
vagina	UBERON:0000996	83.88	gold quality
amniotic fluid	UBERON:0000173	78.58	gold quality
esophagus	UBERON:0001043	78.39	gold quality
parotid gland	UBERON:0001831	78.37	silver quality
gingiva	UBERON:0001828	78.32	gold quality
pharyngeal mucosa	UBERON:0000355	78.08	gold quality
gingival epithelium	UBERON:0001949	77.17	gold quality
mucosa of stomach	UBERON:0001199	77.10	gold quality
mucosa of transverse colon	UBERON:0004991	75.39	gold quality
body of stomach	UBERON:0001161	73.52	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.36	gold quality
urinary bladder	UBERON:0001255	72.18	gold quality
tonsil	UBERON:0002372	71.97	gold quality
fundus of stomach	UBERON:0001160	71.74	gold quality
stomach	UBERON:0000945	71.14	gold quality
colonic epithelium	UBERON:0000397	69.03	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	67.93	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.00	gold quality
ectocervix	UBERON:0012249	66.49	gold quality
transverse colon	UBERON:0001157	64.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.92

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• our analysis of the Esophageal Squamous Cell Carcinoma transcriptome identified the potential tumor suppressing lncRNA Epist (PMID:26158411)
• Low C5orf66-AS1 expression is associated with pituitary null cell adenomas. (PMID:28656268)
• LncRNA C5orf66-AS1, as a competitive endogenous RNA, regulated the effect of RING1 on the proliferation, apoptosis and cell cycle of cervical cancer cells through adsorbing miR-637. (PMID:30518760)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.