ERCC6L2-AS1

Summary

ERCC6L2-AS1 (ERCC6L2 antisense RNA 1, HGNC:27858) is a long non-coding RNA gene on chromosome 9q22.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27858
Approved symbol	ERCC6L2-AS1
Name	ERCC6L2 antisense RNA 1
Location	9q22.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000175611
Ensembl biotype	lncRNA
Entrez	100128782
RNAcentral	URS000075D8BF — lncRNA, 1270 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 28 lncRNA

ENST00000321517, ENST00000412446, ENST00000427259, ENST00000429781, ENST00000433656, ENST00000448465, ENST00000657579, ENST00000660143, ENST00000660645, ENST00000669049, ENST00000670189, ENST00000671508, ENST00000691767, ENST00000702117, ENST00000805844, ENST00000805845, ENST00000805846, ENST00000805847, ENST00000805848, ENST00000805849, ENST00000805850, ENST00000805851, ENST00000805852, ENST00000805853, ENST00000805854, ENST00000805855, ENST00000805856, ENST00000805857

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000321517 — 3 exons

Exon	Start	End
ENSE00001466496	95874509	95874622
ENSE00004198471	95874980	95876010
ENSE00004198480	95870283	95870441

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 84.71.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.0291 / max 102.5390, expressed in 1732 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
101583	3.2641	1189
101582	1.8606	1029
101579	1.3361	785
101580	1.1449	772
101581	0.9945	520
101578	0.4288	185

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	84.71	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.71	gold quality
bone marrow cell	CL:0002092	79.94	gold quality
muscle of leg	UBERON:0001383	79.53	gold quality
gastrocnemius	UBERON:0001388	79.50	gold quality
sural nerve	UBERON:0015488	79.43	gold quality
mucosa of stomach	UBERON:0001199	78.31	gold quality
hindlimb stylopod muscle	UBERON:0004252	77.99	gold quality
left adrenal gland cortex	UBERON:0035825	77.91	gold quality
left adrenal gland	UBERON:0001234	77.72	gold quality
body of stomach	UBERON:0001161	77.14	gold quality
rectum	UBERON:0001052	77.11	gold quality
right adrenal gland	UBERON:0001233	76.71	gold quality
calcaneal tendon	UBERON:0003701	76.61	gold quality
stomach	UBERON:0000945	76.42	gold quality
right atrium auricular region	UBERON:0006631	76.29	gold quality
small intestine Peyer’s patch	UBERON:0003454	76.26	gold quality
cerebellar hemisphere	UBERON:0002245	76.24	gold quality
cerebellar cortex	UBERON:0002129	76.21	gold quality
muscle layer of sigmoid colon	UBERON:0035805	76.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.03	gold quality
left ovary	UBERON:0002119	75.97	gold quality
right adrenal gland cortex	UBERON:0035827	75.97	gold quality
leukocyte	CL:0000738	75.92	gold quality
right coronary artery	UBERON:0001625	75.92	gold quality
popliteal artery	UBERON:0002250	75.88	gold quality
spleen	UBERON:0002106	75.86	gold quality
tibial artery	UBERON:0007610	75.85	gold quality
heart left ventricle	UBERON:0002084	75.82	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC00476 Suppresses the Progression of Non-Small Cell Lung Cancer by Inducing the Ubiquitination of SETDB1. (PMID:33370431)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.