ERICH2

Summary

ERICH2 (glutamate rich 2, HGNC:44395) is a protein-coding gene on chromosome 2q31.1, encoding Glutamate-rich protein 2 (A1L162).

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 2 total — 1 pathogenic
• GTEx eGene: eQTL in 26 tissues, sQTL in 2 (q < 0.05)
• Constraint (gnomAD): pLI 0.10 (intermediate), LOEUF 1.54 (unconstrained)
• MANE Select transcript: NM_001290030

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44395
Approved symbol	ERICH2
Name	glutamate rich 2
Location	2q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000204334
Ensembl biotype	protein_coding
OMIM	620858
Entrez	285141

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 11 protein_coding, 6 protein_coding_CDS_not_defined, 4 nonsense_mediated_decay, 2 retained_intron

MANE Select: ENST00000697325

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 3: 2

ENST00000697325, ENST00000409885, ENST00000426475, ENST00000429172, ENST00000653024, ENST00000654532, ENST00000661942, ENST00000662201, ENST00000662915, ENST00000663589, ENST00000663834, ENST00000664870, ENST00000669009, ENST00000670985, ENST00000671618, ENST00000688829, ENST00000689478, ENST00000697326, ENST00000697327, ENST00000697344, ENST00001128508, ENST00001128509, ENST00001128510

RefSeq mRNA: 8 — MANE Select: NM_001290030 NM_001289947, NM_001290030, NM_001290031, NM_001388467, NM_001388468, NM_001388469, NM_001388470, NM_001388471

CCDS: CCDS77486, CCDS92894, CCDS92895

Canonical transcript exons

ENST00000697325 — 10 exons

Exon	Start	End
ENSE00003970273	170792863	170792920
ENSE00003970274	170777377	170777425
ENSE00003970275	170798770	170798977
ENSE00003970276	170779793	170779888
ENSE00003970277	170770378	170771187
ENSE00003970278	170798041	170798112
ENSE00003970279	170782241	170782389
ENSE00003970280	170784646	170784833
ENSE00003970281	170777644	170777680
ENSE00003970282	170777147	170777177

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 98.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.9468 / max 153.3689, expressed in 1170 samples.

Highest expression (Bgee): testis, male germ line stem cell (sensu Vertebrata) in testis, olfactory segment of nasal mucosa, endometrium, hypothalamus.

Genetic regulation across tissues (GTEx eQTL / sQTL)

ERICH2 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 26 tissues and its splicing (sQTL) in 2 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 28 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Testis	sqtl	1.8e-60	-1.35	2:170785591:GTTAT:G
Artery Tibial	eqtl	1.4e-21	+0.40	2:170377725:C:G
Artery Aorta	eqtl	5.0e-08	+0.41	2:170377725:C:G
Testis	eqtl	8.3e-07	+0.10	2:170753131:C:A
Heart Atrial Appendage	eqtl	2.2e-06	-0.28	2:170716430:G:A
Artery Coronary	eqtl	3.2e-05	+0.44	2:170377725:C:G
Brain Hypothalamus	eqtl	8.6e-05	-0.38	2:170786963:G:C
Nerve Tibial	eqtl	2.4e-04	+0.22	2:170754390:T:TA
Brain Cerebellar Hemisphere	eqtl	3.2e-04	+0.53	2:170786382:G:A
Cells Cultured fibroblasts	eqtl	5.6e-04	-0.17	2:170785846:A:G
Pancreas	eqtl	6.4e-04	-0.34	2:170795855:G:A
Esophagus Mucosa	eqtl	1.4e-03	+0.42	2:170423868:C:T
Brain Cortex	eqtl	1.8e-03	+0.36	2:170774748:G:T
Brain Caudate basal ganglia	eqtl	1.8e-03	-0.32	2:170801872:T:C
Stomach	eqtl	2.5e-03	-0.20	2:170787540:A:G
Brain Anterior cingulate cortex BA24	eqtl	2.9e-03	-0.35	2:170804976:G:A
Heart Left Ventricle	eqtl	3.0e-03	-0.27	2:170787540:A:G
Brain Spinal cord cervical c-1	eqtl	4.2e-03	-0.35	2:170787540:A:G
Thyroid	eqtl	7.0e-03	-0.21	2:170740497:G:C
Esophagus Muscularis	eqtl	9.8e-03	-0.24	2:170787540:A:G

FANTOM5 promoters

showing 10 of 11 alternative TSS:

Promoter ID	TPM avg	Samples expressed
23624	4.6887	1046
23623	1.2914	635
23625	0.3704	188
23622	0.2532	143
23620	0.1375	43
23621	0.1312	61
23627	0.0491	3
23618	0.0107	4
23626	0.0056	3
23619	0.0055	2

Top tissues by expression

showing 100 of 134 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	98.44	gold quality
testis	UBERON:0000473	98.05	gold quality
right testis	UBERON:0004534	98.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.24	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.39	gold quality
endometrium	UBERON:0001295	78.18	gold quality
hypothalamus	UBERON:0001898	78.07	gold quality
right uterine tube	UBERON:0001302	77.80	gold quality
upper lobe of left lung	UBERON:0008952	77.69	gold quality
right lung	UBERON:0002167	76.74	gold quality
amygdala	UBERON:0001876	76.27	gold quality
temporal lobe	UBERON:0001871	76.12	gold quality
lung	UBERON:0002048	76.08	gold quality
substantia nigra	UBERON:0002038	75.27	gold quality
nucleus accumbens	UBERON:0001882	75.21	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.17	gold quality
islet of Langerhans	UBERON:0000006	74.69	gold quality
body of pancreas	UBERON:0001150	74.26	gold quality
fallopian tube	UBERON:0003889	74.02	gold quality
anterior cingulate cortex	UBERON:0009835	74.02	gold quality
Ammon’s horn	UBERON:0001954	73.40	gold quality
body of stomach	UBERON:0001161	73.33	gold quality
pancreas	UBERON:0001264	73.15	gold quality
caudate nucleus	UBERON:0001873	72.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.91	gold quality
putamen	UBERON:0001874	72.85	gold quality
endocervix	UBERON:0000458	72.62	gold quality
tibial artery	UBERON:0007610	72.61	gold quality
popliteal artery	UBERON:0002250	72.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.17	gold quality
cerebral cortex	UBERON:0000956	72.07	gold quality
prefrontal cortex	UBERON:0000451	71.69	gold quality
frontal cortex	UBERON:0001870	71.63	gold quality
right frontal lobe	UBERON:0002810	71.44	gold quality
right atrium auricular region	UBERON:0006631	71.37	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	71.32	gold quality
brain	UBERON:0000955	71.22	gold quality
fundus of stomach	UBERON:0001160	71.16	gold quality
right lobe of liver	UBERON:0001114	71.12	gold quality
apex of heart	UBERON:0002098	70.89	gold quality
superior frontal gyrus	UBERON:0002661	69.84	gold quality
primary visual cortex	UBERON:0002436	69.75	gold quality
stomach	UBERON:0000945	69.72	gold quality
left coronary artery	UBERON:0001626	68.84	gold quality
body of uterus	UBERON:0009853	68.18	gold quality
saliva-secreting gland	UBERON:0001044	68.14	gold quality
mucosa of stomach	UBERON:0001199	68.08	gold quality
minor salivary gland	UBERON:0001830	68.05	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.97	gold quality
descending thoracic aorta	UBERON:0002345	67.94	gold quality
heart	UBERON:0000948	67.84	gold quality
uterine cervix	UBERON:0000002	67.69	gold quality
heart left ventricle	UBERON:0002084	67.69	gold quality
adipose tissue	UBERON:0001013	67.54	gold quality
ectocervix	UBERON:0012249	67.04	gold quality
right adrenal gland cortex	UBERON:0035827	67.02	gold quality
adenohypophysis	UBERON:0002196	66.95	gold quality
omental fat pad	UBERON:0010414	66.95	gold quality
myometrium	UBERON:0001296	66.85	gold quality
left uterine tube	UBERON:0001303	66.84	gold quality
thoracic mammary gland	UBERON:0005200	66.35	gold quality
right adrenal gland	UBERON:0001233	66.34	gold quality
thoracic aorta	UBERON:0001515	66.25	gold quality
ascending aorta	UBERON:0001496	66.16	gold quality
pituitary gland	UBERON:0000007	66.11	gold quality
liver	UBERON:0002107	66.08	gold quality
left adrenal gland	UBERON:0001234	66.02	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.01	gold quality
lower esophagus	UBERON:0013473	65.97	gold quality
calcaneal tendon	UBERON:0003701	65.90	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.81	gold quality
metanephros cortex	UBERON:0010533	65.26	gold quality
cerebellum	UBERON:0002037	65.23	gold quality
cerebellar cortex	UBERON:0002129	65.20	gold quality
cerebellar hemisphere	UBERON:0002245	65.15	gold quality
left adrenal gland cortex	UBERON:0035825	64.92	gold quality
adult mammalian kidney	UBERON:0000082	64.80	gold quality
gall bladder	UBERON:0002110	64.78	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.62	gold quality
tibial nerve	UBERON:0001323	64.39	gold quality
cortex of kidney	UBERON:0001225	64.29	gold quality
urinary bladder	UBERON:0001255	63.77	gold quality
multicellular organism	UBERON:0000468	63.50	gold quality
prostate gland	UBERON:0002367	63.37	gold quality
adrenal gland	UBERON:0002369	63.30	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.96	gold quality
gastrocnemius	UBERON:0001388	62.83	gold quality
right coronary artery	UBERON:0001625	62.83	gold quality
ovary	UBERON:0000992	62.70	gold quality
corpus callosum	UBERON:0002336	62.36	gold quality
muscle of leg	UBERON:0001383	62.14	gold quality
left ovary	UBERON:0002119	62.06	gold quality
kidney	UBERON:0002113	62.04	gold quality
right ovary	UBERON:0002118	61.71	gold quality
thyroid gland	UBERON:0002046	61.58	gold quality
left lobe of thyroid gland	UBERON:0001120	61.48	gold quality
vagina	UBERON:0000996	61.36	gold quality
right lobe of thyroid gland	UBERON:0001119	60.77	gold quality
esophagus	UBERON:0001043	59.94	gold quality
smooth muscle tissue	UBERON:0001135	59.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.38

HPA expression

RNA tissue specificity: Group enriched

showing 60 of 75 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM
Testis	tissue	100.8
Olfactory bulb	tissue	33.6
Choroid plexus	tissue	28.5
Basal ganglia	tissue	12.0
Thyroid gland	tissue	10.0
Nucleus accumbens	tissue	9.7
Septum	tissue	9.3
Lung	tissue	9.1
Periaqueductal gray	tissue	8.1
Cerebellum	tissue	7.8
Ventral forebrain	tissue	7.2
Putamen	tissue	6.6
Fallopian tube	tissue	6.3
Parathyroid gland	tissue	6.2
Hippocampus	tissue	5.7
Retina	tissue	5.2
Locus coeruleus	tissue	5.0
Thalamus	tissue	4.9
Hippocampal formation	tissue	4.8
Hypothalamus	tissue	4.4
Postcentral gyrus	tissue	4.4
Pancreas	tissue	3.8
Amygdala	tissue	3.7
Kidney	tissue	3.5
Epididymis	tissue	3.4
Cervix	tissue	3.2
Superior colliculi	tissue	3.2
Liver	tissue	3.2
Endometrium 1	tissue	3.1
Stomach 1	tissue	2.7
Pons	tissue	2.7
Heart muscle	tissue	2.6
Salivary gland	tissue	2.5
Cerebral cortex	tissue	2.3
Tongue	tissue	2.3
Retrosplenial and cingulate cortex	tissue	2.3
Medulla oblongata	tissue	2.2
Insular cortex	tissue	2.2
Adrenal gland	tissue	2.1
Entorhinal cortex	tissue	2.1
Breast	tissue	2.0
Seminal vesicle	tissue	1.9
Prostate	tissue	1.9
Retrosplenial cortex	tissue	1.9
Temporal cortex	tissue	1.9
Prefrontal cortex	tissue	1.8
Motor cortex	tissue	1.8
Occipital cortex	tissue	1.8
Midbrain	tissue	1.5
Somatosensory cortex	tissue	1.4
Pituitary gland	tissue	1.3
Ovary	tissue	1.3
Corpus callosum	tissue	1.3
Caudate putamen	tissue	1.2
Adipose tissue	tissue	1.1
Vagina	tissue	0.9
Skeletal muscle	tissue	0.8
Substantia nigra	tissue	0.8
Duodenum	tissue	0.8
Spinal cord	tissue	0.8

Brain sub-regions (HPA Brain Atlas): detected in 189; highest nTPM — Arcuate nucleus (12.1), Posterior thalamic nucleus (10.3), Preoptic area (10.2), Dorsomedial nucleus (9.4), Caudate nucleus (9.2).

Regulation

Is transcription factor: no

Functional genomics

gnomAD constraint: pLI 0.104, LOEUF 1.54, missense Z 0.106 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000409885 — one region, missense o/e 1.01.

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	erich2	ENSDARG00000107534
mus_musculus	Erich2	ENSMUSG00000075302
rattus_norvegicus	Erich2	ENSRNOG00000056087
drosophila_melanogaster	CG14853	FBGN0038246

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:1913998) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 1 distinct phenotype terms.

Mouse phenotype (MP)	Records
reproductive system phenotype	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Bos taurus	A6QQ66	76.1%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
MYO3B-AS1	ncRNA	101929753
GAD1-AS1	ncRNA	137805480
MYO3B	protein-coding	140469
GAD1	protein-coding	2571
GORASP2	protein-coding	26003
SP5	protein-coding	389058
LINC01124	ncRNA	440925
ERICH2-DT	ncRNA	101926913
TLK1	protein-coding	9874

Protein

Protein identifiers

Glutamate-rich protein 2 — A1L162 (reviewed: A1L162)

All UniProt accessions (9): A0A8V8TKZ3, A0A8V8TLA6, A0A8V8TLB4, A0A8V8TLB8, A0A8V8TMA0, A0A8V8TMB5, A0A8V8TMI2, A0A8V8TMJ1, A1L162

UniProt curated annotations — full annotation on UniProt →

RefSeq proteins (8): NP_001276876, NP_001276959, NP_001276960, NP_001375396, NP_001375397, NP_001375398, NP_001375399, NP_001375400 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026703	ERICH2	Family

UniProt features (5 total): region of interest 2, compositionally biased region 2, chain 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A1L162-F1	74.23	0.35

Human Protein Atlas

Protein class: Predicted intracellular proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): nucleoli fibrillar center; vesicles

Antibody reliability (HPA): IF approved

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 31 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_DN, MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3, MIR153_5P, MIR12136, MIR335_3P, MIR4503, MIR548AV_5P_MIR548K, MIR8054, MIR302F, MIR2053, MIR20A_3P, MIR3168, MIR802, MIR3922_3P, GSE13306_TREG_VS_TCONV_SPLEEN_UP

GO Molecular Function (1): protein binding (GO:0005515)

GO top-level categories

1 GO namespaces:

Category	Terms
binding	1

Protein interactions and networks

STRING

showing 15 of 158 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ERICH2	PGBD2	Q6P3X8	523
ERICH2	SH3RF3	Q8TEJ3	506
ERICH2	PROSER1	Q86XN7	439
ERICH2	GRAMD2A	Q8IUY3	438
ERICH2	CHAMP1	Q96JM3	410
ERICH2	RHCE	P18577	384
ERICH2	TCF24	Q7RTU0	374
ERICH2	ATAD1	Q8NBU5	348
ERICH2	GPSM1	Q86YR5	348
ERICH2	INSYN1	Q2T9L4	347
ERICH2	PPP1R42	Q7Z4L9	346
ERICH2	TRIM40	Q6P9F5	335
ERICH2	SBK2	P0C263	322
ERICH2	PDPR	Q8NCN5	318
ERICH2	H3BT10	H3BT10	306

IntAct

Human interaction partners of ERICH2 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

6 partners by confidence:

Partner	Interaction type	MIscore	Records
MACROH2A1	physical association	0.720	6
HTT	physical association	0.560	3
IWS1	physical association	0.560	3
PSORS1C2	physical association	0.560	3
SDCBP	physical association	0.560	3
TNF	physical association	0.000	1

BioGRID (6 interactions; top human partners by supporting records): H2AFY (Two-hybrid; 2 records), FBXO7 (Biochemical Activity), IWS1 (Two-hybrid), PSORS1C2 (Two-hybrid), SDCBP (Two-hybrid)

Disease & clinical

Genetic variants

Variant evidence for ERICH2: 2 ClinVar records (1 pathogenic / likely pathogenic); 2 GWAS associations. Per-variant detail is on Sugi Variant.

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (1)

Showing all 1 pathogenic / likely-pathogenic ClinVar records, ranked by ClinVar review status (expert panel → multiple submitters → single submitter), then by number of submitting labs.

Variant ID	HGVS	Classification	Review	Submitters
60252	GRCh38/hg38 2q31.1(chr2:170101430-171243609)x1	Pathogenic	criteria provided, single submitter	1

Per-variant reference — Sugi Variant

Explore ERICH2’s pathogenic and likely-pathogenic variants individually — each with its ClinVar classification and conditions, applied ACMG criteria (ClinGen expert panel, where curated), the calibrated in-silico predictors (AlphaMissense, REVEL, SaProt, conservation), gnomAD frequency, and the predictor-disagreement QC signal — on Sugi Variant.

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 23 predictions of 784):

Position(s)	Effect	Δscore	Sites
2:170784834–170784835	donor_loss	1.0000	3
2:170798762	acceptor_gain	1.0000
2:170798765	acceptor_gain	1.0000
2:170798769	acceptor_loss	1.0000	2
2:170782236	acceptor_gain	0.9900
2:170782390–170782391	donor_loss	0.9900	6
2:170784644–170784645	acceptor_loss	0.9900	6
2:170784822	donor_gain	0.9900
2:170784834	donor_loss	0.9900
2:170792917	donor_gain	0.9900

AlphaMissense

223 missense substitutions predicted likely pathogenic (of 2,842 scored), across 48 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
M78	9	0.888	0.970
M91	9	0.877	0.987
F73	8	0.976	0.999
F105	8	0.942	0.998
N99	8	0.883	0.982
C89	7	0.975	0.996
E96	7	0.957	0.987
E72	7	0.943	0.976
I92	7	0.896	0.993
M70	7	0.868	0.969
P66	6	0.986	0.995
P97	6	0.935	0.966
E68	6	0.922	0.974
A102	6	0.914	0.995
K87	6	0.888	0.930
A65	6	0.827	0.993
E77	6	0.776	0.975
Y82	5	0.961	0.978
A85	5	0.937	0.995
Y95	5	0.934	0.988

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

3 prognostic cancer types:

Cancer	Prognostic	p-value
Glioblastoma Multiforme (validation)	unfavorable	2.51e-07
Kidney Renal Papillary Cell Carcinoma (TCGA)	unfavorable	0.00047
Kidney Chromophobe (TCGA)	unfavorable	0.000841

Disease associations

OMIM: gene MIM:620858 | disease phenotypes:

GWAS associations

2 associations:

Study	Trait	p-value
GCST010244_197	Triglyceride levels	2e-11
GCST009602_82	Metabolic syndrome	3e-8

EFO canonical traits (from GWAS)

2 canonical traits:

EFO ID	Trait name
EFO:0000195	metabolic syndrome
EFO:0004530	triglyceride measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Air Pollutants	increases abundance, increases expression	2
titanium dioxide	decreases expression	1
methylparaben	increases expression	1
versicolorin A	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, increases expression	1
perfluoro-n-nonanoic acid	increases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Dexamethasone	decreases expression	1
Lipopolysaccharides	affects cotreatment, increases expression	1
Smoke	increases abundance, increases expression	1
Okadaic Acid	decreases expression	1
Acrylamide	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.