ERLNC1

Summary

ERLNC1 (estrogen receptor responsive lncRNA 1, HGNC:41109) is a long non-coding RNA gene on chromosome 1q32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41109
Approved symbol	ERLNC1
Name	estrogen receptor responsive lncRNA 1
Location	1q32.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	TC0101441, ElncRNA1
Ensembl gene	ENSG00000230550
Ensembl biotype	lncRNA
Entrez	101929441
RNAcentral	URS0000759FDE — lncRNA, 1140 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000433869, ENST00000654104, ENST00000658822, ENST00000663115, ENST00000840143

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433869 — 3 exons

Exon	Start	End
ENSE00001715390	204142649	204143009
ENSE00001748399	204141408	204141476
ENSE00001785626	204141565	204142260

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 93.67.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0121 / max 9.4728, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
7960	0.0121	3

Top tissues by expression

206 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.67	gold quality
right testis	UBERON:0004534	78.10	gold quality
left testis	UBERON:0004533	76.24	gold quality
testis	UBERON:0000473	73.49	gold quality
right lobe of liver	UBERON:0001114	62.94	gold quality
endothelial cell	CL:0000115	59.95	gold quality
cortical plate	UBERON:0005343	58.92	silver quality
ganglionic eminence	UBERON:0004023	58.49	gold quality
epithelium of nasopharynx	UBERON:0001951	57.73	gold quality
sperm	CL:0000019	56.44	gold quality
liver	UBERON:0002107	55.87	gold quality
stromal cell of endometrium	CL:0002255	55.82	gold quality
superficial temporal artery	UBERON:0001614	55.71	gold quality
adult mammalian kidney	UBERON:0000082	52.92	gold quality
ectocervix	UBERON:0012249	51.76	gold quality
metanephros cortex	UBERON:0010533	51.27	gold quality
oocyte	CL:0000023	51.22	gold quality
adrenal tissue	UBERON:0018303	50.72	gold quality
cortex of kidney	UBERON:0001225	49.68	gold quality
kidney	UBERON:0002113	49.54	gold quality
right coronary artery	UBERON:0001625	48.79	gold quality
islet of Langerhans	UBERON:0000006	48.60	gold quality
prefrontal cortex	UBERON:0000451	48.37	gold quality
right ovary	UBERON:0002118	48.04	gold quality
skin of abdomen	UBERON:0001416	47.47	gold quality
heart left ventricle	UBERON:0002084	47.44	silver quality
left ovary	UBERON:0002119	47.42	gold quality
metanephros	UBERON:0000081	46.99	gold quality
ovary	UBERON:0000992	46.88	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	46.88	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Study provides the first evidence that E2 transcriptionally upregulates ElncRNA1 through the ERalpha-ERE pathway and that this novel E2-upregulated lncRNA has an oncogenic role in epithelial ovarian cancer (EOC) growth. The addition of ElncRNA1 to the E2-ERalpha-ERE signaling pathway may provide greater insight into the oestrogenic effects on EOC progression. (PMID:28714515)
• High TC0101441 expression is associated with induction of epithelial-mesenchymal transition in epithelial ovarian cancer metastasis. (PMID:31577838)
• Analysis of Long Non-Coding RNA (lncRNA) UCA1, MALAT1, TC0101441, and H19 Expression in Endometriosis. (PMID:36232884)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.