ESAM

Summary

ESAM (endothelial cell adhesion molecule, HGNC:17474) is a protein-coding gene on chromosome 11q24.2, encoding Endothelial cell-selective adhesion molecule (Q96AP7). Can mediate aggregation most likely through a homophilic molecular interaction.

Enables cell-cell adhesion mediator activity. Involved in several processes, including bicellular tight junction assembly; cell-cell adhesion; and regulation of actin filament polymerization. Located in cell-cell junction and plasma membrane. Part of protein-containing complex.

Source: NCBI Gene 90952 — RefSeq curated summary.

At a glance

• Gene–disease (curated): neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity (Definitive, GenCC)
• GWAS associations: 5
• Clinical variants (ClinVar): 86 total — 1 pathogenic, 6 likely-pathogenic
• Phenotypes (HPO): 93
• MANE Select transcript: NM_138961

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17474
Approved symbol	ESAM
Name	endothelial cell adhesion molecule
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Aliases	W117m
Ensembl gene	ENSG00000149564
Ensembl biotype	protein_coding
OMIM	614281
Entrez	90952

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 9 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000278927, ENST00000417453, ENST00000435477, ENST00000444566, ENST00000464067, ENST00000485116, ENST00000906450, ENST00000906451, ENST00000906452, ENST00000906453, ENST00000942605, ENST00000942606

RefSeq mRNA: 1 — MANE Select: NM_138961 NM_138961

CCDS: CCDS8453

Canonical transcript exons

ENST00000278927 — 7 exons

Exon	Start	End
ENSE00000991328	124756541	124756742
ENSE00001014314	124758349	124758527
ENSE00001695509	124762085	124762290
ENSE00003494011	124756207	124756362
ENSE00003561465	124753126	124753961
ENSE00003568182	124754641	124754763
ENSE00003665246	124754214	124754340

Expression profiles

Bgee: expression breadth ubiquitous, 227 present calls, max score 98.57.

FANTOM5 (CAGE): breadth broad, TPM avg 10.7628 / max 505.7369, expressed in 787 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
122959	10.4986	732
122960	0.2641	63

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	98.57	gold quality
right lobe of thyroid gland	UBERON:0001119	98.47	gold quality
left lobe of thyroid gland	UBERON:0001120	98.40	gold quality
upper lobe of left lung	UBERON:0008952	98.35	gold quality
right coronary artery	UBERON:0001625	98.31	gold quality
popliteal artery	UBERON:0002250	98.12	gold quality
tibial artery	UBERON:0007610	98.12	gold quality
upper lobe of lung	UBERON:0008948	98.05	gold quality
thyroid gland	UBERON:0002046	97.88	gold quality
apex of heart	UBERON:0002098	97.69	gold quality
left coronary artery	UBERON:0001626	97.59	gold quality
omental fat pad	UBERON:0010414	97.34	gold quality
coronary artery	UBERON:0001621	97.27	gold quality
peritoneum	UBERON:0002358	97.27	gold quality
aorta	UBERON:0000947	96.74	gold quality
adipose tissue of abdominal region	UBERON:0007808	96.72	gold quality
subcutaneous adipose tissue	UBERON:0002190	96.06	gold quality
metanephros cortex	UBERON:0010533	95.99	gold quality
heart left ventricle	UBERON:0002084	95.40	gold quality
cardiac ventricle	UBERON:0002082	95.11	gold quality
ascending aorta	UBERON:0001496	95.10	gold quality
thoracic aorta	UBERON:0001515	95.09	gold quality
lung	UBERON:0002048	94.82	gold quality
tendon of biceps brachii	UBERON:0008188	94.69	gold quality
left uterine tube	UBERON:0001303	94.56	gold quality
heart	UBERON:0000948	94.39	gold quality
body of uterus	UBERON:0009853	94.24	gold quality
right atrium auricular region	UBERON:0006631	94.22	gold quality
placenta	UBERON:0001987	93.90	gold quality
cardiac atrium	UBERON:0002081	93.89	gold quality

Single-cell (SCXA)

Detected in 29 experiment(s), a significant marker in 29.

Experiment	Marker?	Max mean expression
E-MTAB-10662	yes	1501.59
E-MTAB-10137	yes	1127.78
E-MTAB-8142	yes	1005.99
E-MTAB-9906	yes	860.16
E-MTAB-8221	yes	822.81
E-MTAB-8271	yes	775.50
E-ANND-5	yes	524.26
E-CURD-7	yes	432.71
E-ENAD-21	yes	412.20
E-GEOD-83139	yes	309.56
E-MTAB-10287	yes	79.91
E-GEOD-134144	yes	53.45
E-HCAD-1	yes	48.23
E-HCAD-11	yes	48.18
E-HCAD-10	yes	46.36

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NFKB

miRNA regulators (miRDB)

41 targeting ESAM, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-4650-5P	99.98	64.69	999
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-4291	99.20	68.88	2969
HSA-MIR-3152-3P	99.10	66.35	678
HSA-MIR-4270	99.02	66.26	1987
HSA-MIR-6737-3P	98.95	68.56	1577
HSA-MIR-7157-3P	98.95	68.70	1582
HSA-MIR-6889-3P	98.84	67.35	1198
HSA-MIR-5008-3P	98.73	67.50	1433
HSA-MIR-6529-3P	98.68	66.76	1020
HSA-MIR-4725-5P	98.67	65.42	628
HSA-MIR-504-5P	98.67	65.40	631
HSA-MIR-6754-5P	98.60	65.54	1627
HSA-MIR-4662A-5P	98.48	67.18	1007
HSA-MIR-6827-5P	98.46	64.88	1256
HSA-MIR-4483	98.09	64.12	1642

Literature-anchored findings (GeneRIF, showing 7)

• sESAM is a predictive biomarker and potential mediator of atherosclerosis. (PMID:19759376)
• ESAM regulates tumor metastasis through endothelial cell migration and tube formation in metastatic nodules. (PMID:20153339)
• sESAM is associated with albuminuria and reduced kidney function in patients with coronary artery disease in both cross-sectional and longitudinal analyses. (PMID:24177327)
• Serum ESAM is higher in type 2 diabetes mellitus than in controls and parallels oxidative stress. (PMID:24456423)
• sESAM levels associate with myocardial infarction, heart failure, and death after adjustment for demographic and clinical risk factors, but not after adjustment for kidney function. (PMID:26523992)
• ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias (PMID:26774386)
• Bi-allelic variants in the ESAM tight-junction gene cause a neurodevelopmental disorder associated with fetal intracranial hemorrhage. (PMID:36996813)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	esamb	ENSDARG00000076639
danio_rerio	esama	ENSDARG00000077039
danio_rerio	gpa33a	ENSDARG00000100223
mus_musculus	Esam	ENSMUSG00000001946
rattus_norvegicus	Esam	ENSRNOG00000033217

Paralogs (14): VSIG2 (ENSG00000019102), VSIG1 (ENSG00000101842), VSIR (ENSG00000107738), GPA33 (ENSG00000143167), IGSF11 (ENSG00000144847), CXADR (ENSG00000154639), JAM2 (ENSG00000154721), F11R (ENSG00000158769), MXRA8 (ENSG00000162576), JAM3 (ENSG00000166086), CLMP (ENSG00000166250), MUC15 (ENSG00000169550), VSTM2B (ENSG00000187135), VSIG8 (ENSG00000243284)

Protein

Protein identifiers

Endothelial cell-selective adhesion molecule — Q96AP7 (reviewed: Q96AP7)

All UniProt accessions (3): Q96AP7, C9JIE7, F8WDW9

UniProt curated annotations — full annotation on UniProt →

Function. Can mediate aggregation most likely through a homophilic molecular interaction.

Subunit / interactions. Interacts with MAGI1.

Subcellular location. Cell junction. Adherens junction. Tight junction. Cell membrane.

Tissue specificity. Highly expressed in endothelial cells.

Disease relevance. Neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity (NEDIHSS) [MIM:620371] An autosomal recessive disease characterized by prenatal or neonatal onset of intracranial hemorrhage, ventriculomegaly and cerebral calcifications. Affected individuals have profound global developmental delay, intellectual disability, epilepsy, absent or severely delayed speech, and varying degrees of spasticity. Death in utero or in early childhood may occur. The disease is caused by variants affecting the gene represented in this entry.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96AP7-1	1	yes
Q96AP7-2	2

RefSeq proteins (1): NP_620411* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003598	Ig_sub2	Domain
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR013106	Ig_V-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR042757	ESAM	Family

Pfam: PF07686, PF13927

UniProt features (27 total): modified residue 7, glycosylation site 4, splice variant 3, topological domain 2, sequence variant 2, domain 2, signal peptide 1, chain 1, disulfide bond 1, sequence conflict 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96AP7-F1	78.13	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 332, 334, 336, 339, 344, 371, 301

Disulfide bonds (1): 174–224

Glycosylation sites (4): 108, 169, 213, 236

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-202733	Cell surface interactions at the vascular wall

MSigDB gene sets: 421 (showing top): GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, BENPORATH_ES_WITH_H3K27ME3, GOBP_APICAL_JUNCTION_ASSEMBLY, TGACCTY_ERR1_Q2, MEF2_02, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GGGTGGRR_PAX4_03, CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_UP, GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS, GOBP_CELL_CELL_ADHESION, GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE, GOBP_CELL_JUNCTION_ORGANIZATION, GOBP_ACTIN_FILAMENT_ORGANIZATION, GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, PU1_Q6

GO Biological Process (8): homophilic cell-cell adhesion (GO:0007156), intracellular protein localization (GO:0008104), regulation of actin filament polymerization (GO:0030833), regulation of actin cytoskeleton organization (GO:0032956), maintenance of blood-brain barrier (GO:0035633), bicellular tight junction assembly (GO:0070830), cell-cell adhesion (GO:0098609), cell adhesion (GO:0007155)

GO Molecular Function (2): cell-cell adhesion mediator activity (GO:0098632), protein binding (GO:0005515)

GO Cellular Component (7): plasma membrane (GO:0005886), cell-cell junction (GO:0005911), adherens junction (GO:0005912), bicellular tight junction (GO:0005923), protein-containing complex (GO:0032991), membrane (GO:0016020), anchoring junction (GO:0070161)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Hemostasis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell-cell adhesion	2
macromolecule localization	1
regulation of actin polymerization or depolymerization	1
actin filament polymerization	1
regulation of protein polymerization	1
actin cytoskeleton organization	1
regulation of actin filament-based process	1
regulation of cytoskeleton organization	1
tissue homeostasis	1
apical junction assembly	1
tight junction assembly	1
cell adhesion	1
cellular process	1
cell adhesion mediator activity	1
binding	1
membrane	1
cell periphery	1
anchoring junction	1
cell-cell junction	1
apical junction complex	1
tight junction	1
cellular_component	1
cellular anatomical structure	1
cell junction	1

Protein interactions and networks

STRING

1191 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ESAM	OCLN	Q16625	970
ESAM	TJP1	Q07157	857
ESAM	CDH5	P33151	811
ESAM	CLDN5	O00501	754
ESAM	ATP1B1	P05026	746
ESAM	SELE	P16111	734
ESAM	VCAM1	P19320	734
ESAM	SELP	P16109	712
ESAM	VWF	P04275	654
ESAM	PECAM1	P16284	639
ESAM	IGSF5	Q9NSI5	604
ESAM	KDR	P35968	598
ESAM	CD34	P28906	590
ESAM	MARVELD2	Q8N4S9	589
ESAM	SELL	P14151	583

IntAct

11 interactions, top by confidence:

A	B	Type	Score
ESAM	ESAM	psi-mi:“MI:0915”(physical association)	0.610
ESAM	ESAM	psi-mi:“MI:0407”(direct interaction)	0.610
TTMP	ESAM	psi-mi:“MI:0915”(physical association)	0.560
TMBIM6	ESAM	psi-mi:“MI:0915”(physical association)	0.560
ESAM	TOP1	psi-mi:“MI:0914”(association)	0.350
ENG	IGKV2-28	psi-mi:“MI:0914”(association)	0.350

BioGRID (11): MPHOSPH8 (Affinity Capture-MS), TOP1 (Affinity Capture-MS), MDC1 (Affinity Capture-MS), CENPF (Affinity Capture-MS), ESAM (Protein-RNA), ESAM (Two-hybrid), ESAM (Two-hybrid), ESAM (Affinity Capture-MS), ESAM (Affinity Capture-MS), ESAM (Protein-peptide), ESAM (Reconstituted Complex)

ESM2 similar proteins: A0A140LHF2, A6H8M9, A7LCJ3, A8E0Y8, D3YX43, D3YZF7, O14498, O15197, O70394, O70540, P01877, P0C0K6, P0C788, P0DP72, P35590, P40223, P43121, P50895, P70289, Q00657, Q06418, Q06805, Q15109, Q28173, Q5BK54, Q5NVQ6, Q5TJE4, Q61790, Q61826, Q62151, Q62230, Q63495, Q64612, Q6UVK1, Q6UWB1, Q7Z442, Q86VR7, Q8IZF5, Q8R2Y2, Q8VHY0

Diamond homologs: A0A0R4IGV4, A2AJ76, A2ASS6, A3KPA0, D3YXG0, G4SLH0, G5EBF1, O14511, O35569, O88792, P35969, P53767, P56974, P57087, Q00872, Q05793, Q14896, Q2WGK2, Q3UQ28, Q5VST9, Q62718, Q68FQ2, Q7TSU7, Q8NDA2, Q8WZ42, Q95KI3, Q96AP7, Q96RW7, Q99795, Q99PJ0, Q9BX67, Q9D8B7, Q9I7U4, Q9JHY1, Q9JI59, Q9PWR4, Q9VZZ4, Q9XT56, Q9Y624, B4LRN7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

86 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	6
Uncertain significance	59
Likely benign	10
Benign	1

Top pathogenic / likely-pathogenic (7)

Variant ID	HGVS	Classification
4086789	NM_138961.3(ESAM):c.70+1G>T	Pathogenic
1810270	NM_138961.3(ESAM):c.115del (p.Arg39fs)	Likely pathogenic
1810271	NM_138961.3(ESAM):c.287del (p.Pro96fs)	Likely pathogenic
1810272	NM_138961.3(ESAM):c.35T>A (p.Leu12Ter)	Likely pathogenic
1810273	NM_138961.3(ESAM):c.451+1G>A	Likely pathogenic
3065558	NM_138961.3(ESAM):c.949C>T (p.Arg317Ter)	Likely pathogenic
4086169	NM_138961.3(ESAM):c.608-1G>A	Likely pathogenic

SpliceAI

1196 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124754207:CACTT:C	donor_loss	1.0000
11:124754208:ACTTA:A	donor_loss	1.0000
11:124754209:CTTAC:C	donor_loss	1.0000
11:124754210:TTA:T	donor_loss	1.0000
11:124754211:TACT:T	donor_loss	1.0000
11:124754212:A:AC	donor_gain	1.0000
11:124754212:ACTTG:A	donor_loss	1.0000
11:124754213:C:CA	donor_gain	1.0000
11:124754213:CT:C	donor_gain	1.0000
11:124754213:CTT:C	donor_gain	1.0000
11:124754213:CTTG:C	donor_gain	1.0000
11:124754213:CTTGA:C	donor_gain	1.0000
11:124754337:GGCC:G	acceptor_gain	1.0000
11:124754338:GCC:G	acceptor_gain	1.0000
11:124754339:CC:C	acceptor_gain	1.0000
11:124754339:CCC:C	acceptor_gain	1.0000
11:124754340:CC:C	acceptor_gain	1.0000
11:124754341:C:CA	acceptor_loss	1.0000
11:124754341:C:CC	acceptor_gain	1.0000
11:124754351:CGTCG:C	acceptor_gain	1.0000
11:124754628:ACC:A	donor_gain	1.0000
11:124754629:CCC:C	donor_gain	1.0000
11:124754761:CAT:C	acceptor_gain	1.0000
11:124754762:AT:A	acceptor_gain	1.0000
11:124754763:TCTGT:T	acceptor_loss	1.0000
11:124754764:C:CC	acceptor_gain	1.0000
11:124754765:T:A	acceptor_loss	1.0000
11:124756746:G:GC	acceptor_gain	1.0000
11:124753960:CC:C	acceptor_gain	0.9900
11:124753961:CC:C	acceptor_gain	0.9900

AlphaMissense

2470 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:124756253:C:A	W187C	0.999
11:124756253:C:G	W187C	0.999
11:124754700:C:G	C224S	0.995
11:124754701:A:T	C224S	0.995
11:124756255:A:G	W187R	0.993
11:124756255:A:T	W187R	0.993
11:124756622:A:C	Y124D	0.993
11:124754700:C:T	C224Y	0.991
11:124758381:A:G	W73R	0.990
11:124758381:A:T	W73R	0.990
11:124754699:G:C	C224W	0.989
11:124754707:A:C	Y222D	0.989
11:124756293:C:G	C174S	0.989
11:124756294:A:T	C174S	0.989
11:124754701:A:G	C224R	0.987
11:124754706:T:C	Y222C	0.987
11:124756293:C:T	C174Y	0.984
11:124756294:A:G	C174R	0.984
11:124756341:C:G	C158S	0.982
11:124756342:A:T	C158S	0.982
11:124756292:G:C	C174W	0.981
11:124754667:C:G	C235S	0.980
11:124754668:A:T	C235S	0.980
11:124754700:C:A	C224F	0.980
11:124756341:C:T	C158Y	0.979
11:124756664:A:G	S110P	0.978
11:124758379:C:A	W73C	0.978
11:124758379:C:G	W73C	0.978
11:124754668:A:G	C235R	0.977
11:124756342:A:G	C158R	0.977

dbSNP variants (sampled 300 via entrez): RS1000088138 (11:124764272 G>A,C), RS1000496097 (11:124757502 G>A), RS1000650208 (11:124757228 C>T), RS1000783278 (11:124755928 G>A), RS1001000467 (11:124763278 A>C), RS1001170168 (11:124760416 C>A,G), RS1001230595 (11:124762686 G>A,T), RS1002166256 (11:124759347 G>A), RS1002187781 (11:124754406 C>T), RS1002538230 (11:124754885 C>T), RS1002654709 (11:124754535 C>T), RS1002778550 (11:124753122 C>T), RS1003156524 (11:124753442 A>C,G), RS1003172347 (11:124757843 G>A), RS1003540411 (11:124753352 G>C)

Disease associations

OMIM: gene MIM:614281 | disease phenotypes: MIM:620371

GenCC curated gene-disease

Disease	Classification	Inheritance
neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity	Definitive	Autosomal recessive

Mondo (1): neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity (MONDO:0957267)

Orphanet (0):

HPO phenotypes

93 total (30 of 93 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000189	Narrow palate
HP:0000218	High palate
HP:0000232	Everted lower lip vermilion
HP:0000238	Hydrocephalus
HP:0000252	Microcephaly
HP:0000293	Full cheeks
HP:0000303	Mandibular prognathia
HP:0000308	Microretrognathia
HP:0000319	Smooth philtrum
HP:0000325	Triangular face
HP:0000337	Broad forehead
HP:0000341	Narrow forehead
HP:0000358	Posteriorly rotated ears
HP:0000414	Bulbous nose
HP:0000431	Wide nasal bridge
HP:0000463	Anteverted nares
HP:0000476	Cystic hygroma
HP:0000506	Telecanthus
HP:0000527	Long eyelashes
HP:0000541	Retinal detachment
HP:0000573	Retinal hemorrhage
HP:0000582	Upslanted palpebral fissure
HP:0000612	Iris coloboma
HP:0000631	Retinal arterial tortuosity
HP:0000639	Nystagmus
HP:0000646	Amblyopia
HP:0000664	Synophrys
HP:0000750	Delayed speech and language development

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST002539_10	Schizophrenia	3.000000e-12
GCST004521_214	Autism spectrum disorder or schizophrenia	5.000000e-13
GCST006585_44	Blood protein levels	3.000000e-12
GCST006585_807	Blood protein levels	5.000000e-22
GCST006803_11	Schizophrenia	2.000000e-15

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases expression	4
sodium arsenite	decreases expression, increases expression	2
Tobacco Smoke Pollution	increases expression	2
Cyclosporine	increases expression	2
aristolochic acid I	increases expression	1
methyleugenol	increases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
bisphenol A	decreases expression	1
kojic acid	increases expression	1
ethyl-p-hydroxybenzoate	increases expression	1
trichostatin A	affects expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	increases expression	1
tetrabromobisphenol A	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
pentanal	increases expression	1
CGP 52608	increases reaction, affects binding	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
Decitabine	increases expression	1
Aldehydes	increases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Quercetin	increases expression	1
Smoke	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.