ESRG

Summary

ESRG (embryonic stem cell related, HGNC:39079) is a long non-coding RNA gene on chromosome 3p14.3.

Part of nucleus.

Source: NCBI Gene 790952 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39079
Approved symbol	ESRG
Name	embryonic stem cell related
Location	3p14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	HESRG
Ensembl gene	ENSG00000265992
Ensembl biotype	lncRNA
OMIM	611473
Entrez	790952
RNAcentral	URS000075B84B — lncRNA, 3153 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000583516, ENST00000846933, ENST00000846934, ENST00000846935, ENST00000846936, ENST00000846937, ENST00000846938, ENST00000846939, ENST00000846940, ENST00000846941, ENST00000846942, ENST00000846943, ENST00000846944, ENST00000846945, ENST00000846946, ENST00000846947, ENST00000846948, ENST00000846949, ENST00000846950, ENST00000846951, ENST00000846952, ENST00000846953, ENST00000846954, ENST00000846955, ENST00000846956

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583516 — 4 exons

Exon	Start	End
ENSE00002707332	54633559	54633740
ENSE00002716063	54637691	54639857
ENSE00002719864	54634461	54634565
ENSE00002723019	54632122	54632807

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 86.68.

Top tissues by expression

187 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	86.68	gold quality
ectocervix	UBERON:0012249	84.37	gold quality
sural nerve	UBERON:0015488	79.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.88	silver quality
vagina	UBERON:0000996	72.04	gold quality
uterine cervix	UBERON:0000002	68.48	gold quality
left ovary	UBERON:0002119	65.67	gold quality
secondary oocyte	CL:0000655	64.90	silver quality
cortical plate	UBERON:0005343	62.59	silver quality
skin of abdomen	UBERON:0001416	58.93	gold quality
upper leg skin	UBERON:0004262	57.60	silver quality
monocyte	CL:0000576	56.24	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.97	gold quality
calcaneal tendon	UBERON:0003701	55.51	silver quality
blood	UBERON:0000178	54.17	gold quality
zone of skin	UBERON:0000014	53.81	gold quality
ganglionic eminence	UBERON:0004023	53.64	silver quality
skin of leg	UBERON:0001511	52.86	gold quality
female reproductive system	UBERON:0000474	52.72	gold quality
right lobe of liver	UBERON:0001114	52.66	gold quality
stromal cell of endometrium	CL:0002255	52.58	silver quality
ovary	UBERON:0000992	51.15	gold quality
skin of hip	UBERON:0001554	51.05	gold quality
subcutaneous adipose tissue	UBERON:0002190	50.88	gold quality
body of pancreas	UBERON:0001150	49.83	gold quality
minor salivary gland	UBERON:0001830	49.05	gold quality
cerebellar vermis	UBERON:0004720	48.93	gold quality
adult mammalian kidney	UBERON:0000082	48.89	gold quality
tonsil	UBERON:0002372	48.59	silver quality
esophagus mucosa	UBERON:0002469	48.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.21

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): POU5F1

Literature-anchored findings (GeneRIF, showing 5)

• The above suggested an important role for the novel HESRG gene in supporting the undifferentiated state or self-renewal of hES cells. (PMID:17803967)
• HESRG is a novel, sensitive and specific biomarker for intracranial germinoma and embryonal carcinoma. (PMID:21861197)
• Data indicate that the embryonic stem cell related gene (ESRG) protein was located in the nuclei of embryonic stem cells (hESCs). (PMID:23628413)
• The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency. (PMID:34033652)
• ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway. (PMID:36778110)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.