ETV3

Summary

ETV3 (ETS variant transcription factor 3, HGNC:3492) is a protein-coding gene on chromosome 1q23.1, encoding ETS translocation variant 3 (P41162). Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation.

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm.

Source: NCBI Gene 2117 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 70 total
• Transcription factor: yes — 14 downstream targets (CollecTRI)
• MANE Select transcript: NM_001145312

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:3492
Approved symbol	ETV3
Name	ETS variant transcription factor 3
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Aliases	PE-1
Ensembl gene	ENSG00000117036
Ensembl biotype	protein_coding
OMIM	164873
Entrez	2117

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000326786, ENST00000368192, ENST00000460850

RefSeq mRNA: 2 — MANE Select: NM_001145312 NM_001145312, NM_005240

CCDS: CCDS1164, CCDS44250

Canonical transcript exons

ENST00000368192 — 5 exons

Exon	Start	End
ENSE00000788872	157135471	157135708
ENSE00000904829	157134112	157134227
ENSE00001249474	157121191	157125979
ENSE00001446530	157138316	157138395
ENSE00003648571	157136307	157136365

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 97.28.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.1051 / max 551.3671, expressed in 1795 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
15259	10.4244	1731
15260	3.9981	1637
15261	1.3982	744
15262	0.1103	41
15263	0.1100	28
15264	0.0643	14

Top tissues by expression

264 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper arm skin	UBERON:0004263	97.28	gold quality
upper leg skin	UBERON:0004262	96.70	gold quality
skin of hip	UBERON:0001554	95.70	gold quality
gingival epithelium	UBERON:0001949	94.82	gold quality
jejunal mucosa	UBERON:0000399	94.48	gold quality
gingiva	UBERON:0001828	94.47	gold quality
palpebral conjunctiva	UBERON:0001812	93.86	gold quality
corpus epididymis	UBERON:0004359	93.10	gold quality
esophagus squamous epithelium	UBERON:0006920	92.75	gold quality
cardiac muscle of right atrium	UBERON:0003379	92.54	silver quality
cauda epididymis	UBERON:0004360	92.51	gold quality
amniotic fluid	UBERON:0000173	92.29	gold quality
epithelial cell of pancreas	CL:0000083	92.03	silver quality
mucosa of paranasal sinus	UBERON:0005030	92.02	gold quality
mucosa of sigmoid colon	UBERON:0004993	91.92	gold quality
caput epididymis	UBERON:0004358	91.85	gold quality
left ventricle myocardium	UBERON:0006566	91.78	silver quality
parietal pleura	UBERON:0002400	91.48	gold quality
epithelium of mammary gland	UBERON:0003244	91.42	gold quality
mammary duct	UBERON:0001765	91.39	gold quality
epithelium of nasopharynx	UBERON:0001951	91.36	gold quality
mammalian vulva	UBERON:0000997	90.91	gold quality
nasal cavity epithelium	UBERON:0005384	90.49	gold quality
oral cavity	UBERON:0000167	90.48	gold quality
visceral pleura	UBERON:0002401	90.40	gold quality
penis	UBERON:0000989	90.32	gold quality
colonic mucosa	UBERON:0000317	90.24	gold quality
zone of skin	UBERON:0000014	90.21	gold quality
cartilage tissue	UBERON:0002418	90.10	gold quality
skin of abdomen	UBERON:0001416	89.80	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-8498	yes	1088.89
E-ANND-3	yes	9.77
E-MTAB-2983	no	431.65

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

14 targets.

Target	Regulation
AP1
CAT
CDK1	Repression
DDX20	Repression
DUSP6	Repression
ERF
ETV3	Repression
FGF2
KRAS
MMP1	Unknown
MYB	Repression
MYC	Repression
NFKB1	Repression
RELA	Repression

JASPAR motifs

Motif	Name	Family
MA0763.1	ETV3	Ets-related
MA0763.2	ETV3	Ets-related

JASPAR matrix evidence (PMIDs): PMID:20517297

Upstream regulators (CollecTRI, top): CREB1, CREM, ETV3, STAT3

miRNA regulators (miRDB)

63 targeting ETV3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-609	99.82	64.26	505
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-5580-3P	99.70	69.41	2052
HSA-MIR-497-3P	99.61	69.71	1990
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-3682-3P	99.58	67.63	865
HSA-MIR-5004-3P	99.54	68.27	1371
HSA-MIR-671-5P	99.52	67.11	1277

Literature-anchored findings (GeneRIF, showing 6)

• PE-1/METS is an antiproliferative Ets repressor factor induced by CREB-1/CREM-1 during macrophage differentiation (PMID:14754893)
• Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS. (PMID:17525531)
• The ETV3 expression was strongly induced by the STAT3 pathway regulated by IL-10 but not by STAT3 signaling activated by IL-6, which cannot activate the anti-inflammatory signaling pathway. (PMID:18025162)
• Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes. (PMID:23329352)
• Case Reports/Review: indeterminate dendritic cell tumor lacking the ETV3-NCOA2 translocation. (PMID:29877893)
• ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment. (PMID:36543959)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Etv3	ENSMUSG00000003382
rattus_norvegicus	Etv3	ENSRNOG00000043095

Paralogs (28): ETV1 (ENSG00000006468), ETV7 (ENSG00000010030), SPI1 (ENSG00000066336), ELF4 (ENSG00000102034), ETV2 (ENSG00000105672), ERF (ENSG00000105722), ELF2 (ENSG00000109381), ELK3 (ENSG00000111145), ELF1 (ENSG00000120690), SPDEF (ENSG00000124664), ELK1 (ENSG00000126767), ETS1 (ENSG00000134954), EHF (ENSG00000135373), ELF5 (ENSG00000135374), ETV6 (ENSG00000139083), FLI1 (ENSG00000151702), GABPA (ENSG00000154727), ERG (ENSG00000157554), ETS2 (ENSG00000157557), ELK4 (ENSG00000158711), ELF3 (ENSG00000163435), FEV (ENSG00000163497), SPIC (ENSG00000166211), ETV4 (ENSG00000175832), ETV5 (ENSG00000244405), ETV3L (ENSG00000253831), ERFL (ENSG00000268041), SPIB (ENSG00000269404)

Protein

Protein identifiers

ETS translocation variant 3 — P41162 (reviewed: P41162)

Alternative names: ETS domain transcriptional repressor PE1, Mitogenic Ets transcriptional suppressor

All UniProt accessions (1): P41162

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Subcellular location. Nucleus.

Similarity. Belongs to the ETS family.

Isoforms (2)

UniProt ID	Names	Canonical?
P41162-1	1, Long	yes
P41162-2	2, Short

RefSeq proteins (2): NP_001138784, NP_005231 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000418	Ets_dom	Domain
IPR036388	WH-like_DNA-bd_sf	Homologous_superfamily
IPR036390	WH_DNA-bd_sf	Homologous_superfamily
IPR046328	ETS_fam	Family

Pfam: PF00178

UniProt features (16 total): modified residue 4, compositionally biased region 4, cross-link 2, splice variant 2, region of interest 2, chain 1, DNA-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P41162-F1	56.10	0.17

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 315, 388, 381, 388, 139, 159

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 230 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, WANG_CLIM2_TARGETS_UP, YAGI_AML_WITH_INV_16_TRANSLOCATION, GOBP_RESPONSE_TO_PEPTIDE, AREB6_01, MORF_ESR1, NKX62_Q2, AAACCAC_MIR140, FOSTER_TOLERANT_MACROPHAGE_UP, MODULE_123, MORF_ETV3, MODULE_88, BIOCARTA_ETS_PATHWAY, MAF_Q6, MODULE_113

GO Biological Process (6): regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of cell population proliferation (GO:0008285), cell differentiation (GO:0030154), cellular response to granulocyte macrophage colony-stimulating factor stimulus (GO:0097011), negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (8): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), DEAD/H-box RNA helicase binding (GO:0017151), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), sequence-specific DNA binding (GO:0043565)

GO Cellular Component (5): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), RNA polymerase II transcription repressor complex (GO:0090571), transcription repressor complex (GO:0017053)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
transcription cis-regulatory region binding	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
cellular anatomical structure	2
cell population proliferation	1
regulation of cell population proliferation	1
negative regulation of cellular process	1
cellular developmental process	1
cellular response to cytokine stimulus	1
response to granulocyte macrophage colony-stimulating factor	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
enzyme binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
transcription regulator activity	1
DNA binding	1
chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
transcription repressor complex	1
nuclear protein-containing complex	1
transcription regulator complex	1

Protein interactions and networks

STRING

596 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ETV3	FOXL2	P58012	643
ETV3	DDX20	Q9UHI6	625
ETV3	NCOA2	Q15596	558
ETV3	GEMIN2	O14893	544
ETV3	ETV5	P41161	538
ETV3	SBNO2	Q9Y2G9	512
ETV3	IRF8	Q02556	504
ETV3	GEMIN4	P57678	497
ETV3	MYC	P01106	468
ETV3	NR5A1	Q13285	438
ETV3	FOXD1	Q16676	410
ETV3	HIVEP1	P15822	394
ETV3	EBF1	Q9UH73	393
ETV3	AGO2	Q9UKV8	385
ETV3	ETV6	P41212	385

IntAct

72 interactions, top by confidence:

A	B	Type	Score
RCCD1	SPAG9	psi-mi:“MI:0914”(association)	0.640
CXCR4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
HSPB8	VWA8	psi-mi:“MI:0914”(association)	0.530
CLEC11A	VWA8	psi-mi:“MI:0914”(association)	0.530
TRAK2	OGT	psi-mi:“MI:0914”(association)	0.530
ANGPTL7	TCP1	psi-mi:“MI:0914”(association)	0.530
	ETV3	psi-mi:“MI:0915”(physical association)	0.370
CCL2	ETV3	psi-mi:“MI:0915”(physical association)	0.370
XCL1	ETV3	psi-mi:“MI:0915”(physical association)	0.370
ETV3	NSD3	psi-mi:“MI:0915”(physical association)	0.370
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
OLFM4	DDX11L8	psi-mi:“MI:0914”(association)	0.350
PROZ	ARVCF	psi-mi:“MI:0914”(association)	0.350
PCDHB11	CBX4	psi-mi:“MI:0914”(association)	0.350
CSN1S1	HSPA5	psi-mi:“MI:0914”(association)	0.350
MAPK1	SEC16A	psi-mi:“MI:0914”(association)	0.350
SOX2	CBX4	psi-mi:“MI:0914”(association)	0.350
ETV3	XPOT	psi-mi:“MI:0914”(association)	0.350
MYC	IGF2BP3	psi-mi:“MI:0914”(association)	0.350
MYC		psi-mi:“MI:0914”(association)	0.350
BSCL2	TMEM223	psi-mi:“MI:0914”(association)	0.350
THSD4	KRBA1	psi-mi:“MI:0914”(association)	0.350
TMEM106A	RTL8C	psi-mi:“MI:0914”(association)	0.350
PCDHB11	SDCBP	psi-mi:“MI:0914”(association)	0.350
PROZ	MAP2K7	psi-mi:“MI:0914”(association)	0.350
TBL1Y	HDAC3	psi-mi:“MI:0914”(association)	0.350
OLFM4	HSPA5	psi-mi:“MI:0914”(association)	0.350
CSN1S1	TIMP3	psi-mi:“MI:0914”(association)	0.350

BioGRID (143): ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS), ETV3 (Reconstituted Complex), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-RNA), ETV3 (Affinity Capture-MS), ETV3 (Affinity Capture-MS)

ESM2 similar proteins: A1YF15, A1YG91, A2D4Z7, A2T762, A9ZPC9, C0LZJ1, O00409, O42261, P08651, P21999, P23767, P28324, P31258, P31629, P41162, P41970, P41971, P48437, P59667, P70056, P70284, P85119, Q00900, Q12951, Q1LY77, Q28G71, Q28GC4, Q29131, Q33BP8, Q3BJS3, Q499D0, Q61602, Q6DIB4, Q8CGW4, Q8R4Z4, Q8VII8, Q90655, Q90YI8, Q90ZH8, Q91018

Diamond homologs: A0A1W2PQ73, A0JN51, A1A4L6, A1YF15, A1YG61, A1YG91, A2D4Z7, A2T737, A2T762, A3FEM2, A4GTP4, A8WFJ9, O00321, O01519, O70132, O70273, O95238, P01105, P10157, P11308, P11536, P13474, P14921, P15036, P15037, P15062, P18755, P18756, P19102, P19419, P20105, P26323, P27577, P28322, P28324, P29773, P29774, P29775, P29776, P32519

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
MAPK1	“down-regulates activity”	ETV3	phosphorylation
ETV3	“down-regulates quantity by repression”	ETV3	“transcriptional regulation”
ETV3	“down-regulates quantity by repression”	DDX20	“transcriptional regulation”
ETV3	“down-regulates quantity by repression”	DUSP6	“transcriptional regulation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

70 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	62
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

827 predictions. Top by Δscore:

Variant	Effect	Δscore
1:157124834:T:TA	donor_gain	1.0000
1:157134105:ATCTT:A	donor_loss	1.0000
1:157134107:CTTAC:C	donor_loss	1.0000
1:157134108:TTACC:T	donor_loss	1.0000
1:157134110:A:AC	donor_gain	1.0000
1:157134110:ACCAC:A	donor_loss	1.0000
1:157134111:C:CC	donor_gain	1.0000
1:157134111:CCA:C	donor_gain	1.0000
1:157134116:TG:T	donor_gain	1.0000
1:157134223:AGTAT:A	acceptor_gain	1.0000
1:157134224:GTAT:G	acceptor_gain	1.0000
1:157134224:GTATC:G	acceptor_loss	1.0000
1:157134225:TAT:T	acceptor_gain	1.0000
1:157134226:AT:A	acceptor_gain	1.0000
1:157134227:TC:T	acceptor_loss	1.0000
1:157134228:C:CC	acceptor_gain	1.0000
1:157134228:CTGT:C	acceptor_loss	1.0000
1:157134229:T:A	acceptor_loss	1.0000
1:157135465:CCTTA:C	donor_loss	1.0000
1:157135466:CTTAC:C	donor_loss	1.0000
1:157135467:TTAC:T	donor_loss	1.0000
1:157135468:TACC:T	donor_loss	1.0000
1:157135469:A:AC	donor_gain	1.0000
1:157135470:C:CC	donor_gain	1.0000
1:157135714:A:C	acceptor_gain	1.0000
1:157136295:A:C	donor_gain	1.0000
1:157138312:TCAC:T	donor_loss	1.0000
1:157138314:A:AC	donor_gain	1.0000
1:157138315:C:CG	donor_gain	1.0000
1:157138315:CCT:C	donor_gain	1.0000

AlphaMissense

3347 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:157134167:A:C	F115L	1.000
1:157134167:A:T	F115L	1.000
1:157134168:A:C	F115C	1.000
1:157134168:A:G	F115S	1.000
1:157134169:A:C	F115V	1.000
1:157134169:A:G	F115L	1.000
1:157134169:A:T	F115I	1.000
1:157134175:A:C	Y113D	1.000
1:157134175:A:G	Y113H	1.000
1:157134175:A:T	Y113N	1.000
1:157134179:A:C	F111L	1.000
1:157134179:A:T	F111L	1.000
1:157134180:A:C	F111C	1.000
1:157134180:A:G	F111S	1.000
1:157134181:A:C	F111V	1.000
1:157134181:A:G	F111L	1.000
1:157134181:A:T	F111I	1.000
1:157134182:T:A	R110S	1.000
1:157134182:T:G	R110S	1.000
1:157134189:C:T	G108E	1.000
1:157134190:C:G	G108R	1.000
1:157134190:C:T	G108R	1.000
1:157134197:T:A	K105N	1.000
1:157134197:T:G	K105N	1.000
1:157134198:T:A	K105I	1.000
1:157134198:T:G	K105T	1.000
1:157134199:T:C	K105E	1.000
1:157134199:T:G	K105Q	1.000
1:157134204:A:C	L103R	1.000
1:157134204:A:G	L103P	1.000

dbSNP variants (sampled 300 via entrez): RS1000148307 (1:157138258 G>A,T), RS1000194380 (1:157121374 C>T), RS1000276881 (1:157132273 T>C), RS1000422932 (1:157124335 C>T), RS1000586929 (1:157123846 A>G), RS1000678395 (1:157133374 G>A,C), RS1000900571 (1:157133070 A>G), RS1001106804 (1:157138733 G>A,C), RS1001114952 (1:157136671 T>C,G), RS1001192805 (1:157126418 T>C), RS1001318092 (1:157138521 T>C,G), RS1001489802 (1:157132669 G>A), RS1001599677 (1:157124765 C>A,G,T), RS1001638476 (1:157121765 T>C), RS1001679604 (1:157127543 T>C)

Disease associations

OMIM: gene MIM:164873 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000253_11	Attention deficit hyperactivity disorder and conduct disorder	8.000000e-06
GCST011956_52	Systemic lupus erythematosus	7.000000e-16
GCST012286_1	Hepatitis B virus-related hepatocellular carcinoma vs hepatitis B virus-related decompensated cirrhosis	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008505	hepatitis virus-related hepatocellular carcinoma

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation, decreases methylation, increases mutagenesis	2
Lipopolysaccharides	decreases reaction, increases expression, affects response to substance, affects cotreatment	2
Valproic Acid	increases expression, increases methylation	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	decreases phosphorylation	1
TAK-243	increases sumoylation	1
bisphenol A	increases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
trichostatin A	affects expression	1
arsenite	affects binding, decreases reaction	1
cobaltous chloride	increases expression	1
butyraldehyde	increases expression	1
zinc chromate	increases abundance, increases expression	1
coenzyme Q10	decreases reaction, increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
potassium chromate(VI)	increases expression, affects cotreatment	1
4-hydroxy-2-nonenal	decreases expression	1
coumarin	increases phosphorylation	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, affects response to substance, increases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
chromium hexavalent ion	increases abundance, increases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
abrine	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
gardiquimod	increases expression, decreases reaction	1
Sunitinib	increases expression	1
Arsenic Trioxide	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A1N4	SEES3-1V human ETV3, clone1	Embryonic stem cell	Male
CVCL_A1N5	SEES3-1V human ETV3, clone2	Embryonic stem cell	Male
CVCL_A1N6	SEES3-1V human ETV3, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.