EWSAT1

Summary

EWSAT1 (Ewing sarcoma associated transcript 1, HGNC:26596) is a long non-coding RNA gene on chromosome 15q23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26596
Approved symbol	EWSAT1
Name	Ewing sarcoma associated transcript 1
Location	15q23
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ33768
Ensembl gene	ENSG00000212766
Ensembl biotype	lncRNA
OMIM	616492
Entrez	283673
RNAcentral	URS000075A2A2 — lncRNA, 2527 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000415504, ENST00000435479, ENST00000440444, ENST00000558147, ENST00000558369, ENST00000558922, ENST00000559870, ENST00000559914, ENST00000559964, ENST00000822241, ENST00000822242, ENST00000822243, ENST00000822244, ENST00000822245, ENST00000822246, ENST00000822247, ENST00000822248, ENST00000822358

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415504 — 5 exons

Exon	Start	End
ENSE00001599099	69094701	69095807
ENSE00001637392	69074584	69074674
ENSE00001660400	69091692	69092242
ENSE00001716721	69072926	69073190
ENSE00003596944	69090915	69091114

Expression profiles

Bgee: expression breadth ubiquitous, 149 present calls, max score 92.54.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2581 / max 45.7846, expressed in 64 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147434	0.1840	39
147433	0.0435	14
147432	0.0239	3
147430	0.0041	2
147431	0.0027	2

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.54	gold quality
sperm	CL:0000019	84.88	gold quality
left testis	UBERON:0004533	83.49	gold quality
right testis	UBERON:0004534	82.59	gold quality
testis	UBERON:0000473	79.89	gold quality
ileal mucosa	UBERON:0000331	78.52	silver quality
right uterine tube	UBERON:0001302	77.79	gold quality
tibialis anterior	UBERON:0001385	77.43	silver quality
ganglionic eminence	UBERON:0004023	67.63	gold quality
metanephros cortex	UBERON:0010533	66.16	gold quality
pancreatic ductal cell	CL:0002079	65.44	silver quality
right adrenal gland cortex	UBERON:0035827	64.76	gold quality
cortical plate	UBERON:0005343	64.73	gold quality
right adrenal gland	UBERON:0001233	64.60	gold quality
adenohypophysis	UBERON:0002196	63.49	gold quality
deltoid	UBERON:0001476	62.45	gold quality
cerebellar vermis	UBERON:0004720	62.08	silver quality
prefrontal cortex	UBERON:0000451	61.94	gold quality
ventricular zone	UBERON:0003053	61.93	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.48	gold quality
cortex of kidney	UBERON:0001225	60.63	gold quality
nucleus accumbens	UBERON:0001882	60.60	gold quality
cerebellar hemisphere	UBERON:0002245	60.57	gold quality
cerebellar cortex	UBERON:0002129	60.45	gold quality
pituitary gland	UBERON:0000007	60.32	gold quality
hypothalamus	UBERON:0001898	60.29	gold quality
left adrenal gland	UBERON:0001234	60.09	gold quality
left adrenal gland cortex	UBERON:0035825	60.08	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.85	gold quality
right frontal lobe	UBERON:0002810	59.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• data reveal that EWSAT1 is a downstream target of EWS-FLI1 that facilitates the development of Ewing sarcoma via the repression of target genes. (PMID:25401475)
• Collectively, our data revealed that EWSAT1 promotes nasopharyngeal carcinoma cell growth in vitro through up-regulating cyclin D1 partially via ‘spongeing’ miR-326/330-5p clusters. (PMID:27816050)
• EWSAT1 promotes osteosarcoma cell growth and metastasis through suppression of MEG3 expression. (PMID:27860482)
• HPV-positive cervical neoplasia patients exhibit significantly reduced LINC01101 and LINC00277 expression levels. (PMID:28767188)
• Increased EWSAT1 expression promotes cell proliferation, invasion and epithelial-mesenchymal transition in colorectal cancer cells. (PMID:30402843)
• LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development. (PMID:32556917)
• EWSAT1 Acts in Concert with Exosomes in Osteosarcoma Progression and Tumor-Induced Angiogenesis: The ““Double Stacking Effect””. (PMID:32803878)
• LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis. (PMID:33928467)
• LncRNA-EWSAT1 promotes hepatocellular carcinoma metastasis via activation of the Src-YAP signaling axis. (PMID:36421017)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.