EXD2

Summary

EXD2 (exonuclease 3’-5’ domain containing 2, HGNC:20217) is a protein-coding gene on chromosome 14q24.1, encoding Exonuclease 3’-5’ domain-containing protein 2 (Q9NVH0). Exonuclease that has both 3’-5’ exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor.

Enables 3’-5’ exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in DNA double-strand break processing; double-strand break repair via homologous recombination; and replication fork processing. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage.

Source: NCBI Gene 55218 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 98 total
• MANE Select transcript: NM_001193360

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20217
Approved symbol	EXD2
Name	exonuclease 3’-5’ domain containing 2
Location	14q24.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10738
Ensembl gene	ENSG00000081177
Ensembl biotype	protein_coding
OMIM	616940
Entrez	55218

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 25 protein_coding, 4 protein_coding_CDS_not_defined, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000312994, ENST00000409014, ENST00000409018, ENST00000409242, ENST00000409675, ENST00000409949, ENST00000413191, ENST00000461908, ENST00000465286, ENST00000487724, ENST00000489133, ENST00000492815, ENST00000494629, ENST00000685843, ENST00000904158, ENST00000904159, ENST00000904160, ENST00000904161, ENST00000904162, ENST00000904163, ENST00000904164, ENST00000904165, ENST00000904166, ENST00000922337, ENST00000922338, ENST00000922339, ENST00000922340, ENST00000922341, ENST00000969916, ENST00000969917, ENST00000969918

RefSeq mRNA: 5 — MANE Select: NM_001193360 NM_001193360, NM_001193361, NM_001193362, NM_001193363, NM_018199

CCDS: CCDS53902, CCDS9793

Canonical transcript exons

ENST00000685843 — 10 exons

Exon	Start	End
ENSE00001535336	69203917	69204000
ENSE00001642342	69234700	69235031
ENSE00003489248	69236407	69236542
ENSE00003532509	69236046	69236152
ENSE00003541435	69209424	69209803
ENSE00003628844	69228816	69229072
ENSE00003631401	69237575	69237931
ENSE00003784728	69230472	69230598
ENSE00003922965	69191498	69191591
ENSE00003929373	69240884	69244018

Expression profiles

Bgee: expression breadth ubiquitous, 284 present calls, max score 91.77.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.1726 / max 162.8225, expressed in 1732 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140324	8.2056	1719
140325	1.9670	830

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	91.77	gold quality
ventricular zone	UBERON:0003053	90.94	gold quality
body of pancreas	UBERON:0001150	90.55	gold quality
ganglionic eminence	UBERON:0004023	89.37	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	88.79	gold quality
pancreas	UBERON:0001264	88.34	gold quality
spinal cord	UBERON:0002240	88.03	gold quality
islet of Langerhans	UBERON:0000006	87.64	gold quality
mucosa of paranasal sinus	UBERON:0005030	87.46	gold quality
adult organism	UBERON:0007023	87.29	gold quality
olfactory bulb	UBERON:0002264	87.16	gold quality
cerebellar hemisphere	UBERON:0002245	87.03	gold quality
prefrontal cortex	UBERON:0000451	87.02	gold quality
right uterine tube	UBERON:0001302	87.02	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.00	gold quality
caudate nucleus	UBERON:0001873	86.91	gold quality
cerebellar cortex	UBERON:0002129	86.91	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.57	gold quality
right frontal lobe	UBERON:0002810	86.40	gold quality
putamen	UBERON:0001874	86.27	gold quality
smooth muscle tissue	UBERON:0001135	86.19	gold quality
cerebellum	UBERON:0002037	86.08	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.98	gold quality
nucleus accumbens	UBERON:0001882	85.98	gold quality
diaphragm	UBERON:0001103	85.96	gold quality
epithelium of nasopharynx	UBERON:0001951	85.90	gold quality
nasopharynx	UBERON:0001728	85.89	gold quality
hair follicle	UBERON:0002073	85.85	silver quality
frontal cortex	UBERON:0001870	85.75	gold quality
tongue squamous epithelium	UBERON:0006919	85.75	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.54
E-GEOD-99795	no	89.63

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

144 targeting EXD2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-539-5P	99.93	70.30	2855

Literature-anchored findings (GeneRIF, showing 4)

• establish that EXD2 stimulates both short- and long-range DSB resection (PMID:26807646)
• EXD2 re-locates to the nucleus following double-strand breaks and thus is unlikely to have a direct role in nuclear DNA repair. Knockdown or overexpression of EXD2 affects the cellular distribution of mitochondria. (PMID:29599527)
• EXD2 is anchored to the mitochondrial outer membrane through a conserved N-terminal transmembrane domain, while the C-terminal region is cytosolic. Crystal structures of the exonuclease domain in complex with Mn2+/Mg2+ revealed a domain-swapped dimer in which the central alpha5-alpha7 helices are mutually crossed over, resulting in chimeric active sites. (PMID:31127291)
• EXD2 deficiency leads to fork collapse, hypersensitivity to replication inhibitors, and genomic instability. Impeding fork regression by inactivation of SMARCAL1 or removal of RECQ1’s inhibition in EXD2(-/-) cells restores efficient fork restart and genome stability. Moreover, purified EXD2 efficiently processes substrates mimicking regressed forks. (PMID:31255466)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	exd2	ENSDARG00000016117
mus_musculus	Exd2	ENSMUSG00000032705
rattus_norvegicus	Exd2	ENSRNOG00000027707
drosophila_melanogaster	Exd2	FBGN0037901

Paralogs (1): EXD3 (ENSG00000187609)

Protein

Protein identifiers

Exonuclease 3’-5’ domain-containing protein 2 — Q9NVH0 (reviewed: Q9NVH0)

Alternative names: 3’-5’ exoribonuclease EXD2, Exonuclease 3’-5’ domain-like-containing protein 2

All UniProt accessions (3): Q9NVH0, A0A8I5KSH7, C9JLF4

UniProt curated annotations — full annotation on UniProt →

Function. Exonuclease that has both 3’-5’ exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3’-5’ exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3’-5’ exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3’-5’ exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation.

Subunit / interactions. Homodimer. Interacts with RBBP8, MRE11 and BRCA1.

Subcellular location. Mitochondrion outer membrane. Mitochondrion matrix. Nucleus. Chromosome.

Cofactor. Divalent metal cations; Mg(2+) or Mn(2+). Acts as a 3’-5’ exoribonuclease in presence of Mg(2+), while it has no 3’-5’ exodeoxyribonuclease activity. Has both as a 3’-5’ exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+).

Similarity. Belongs to the EXD2 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NVH0-1	1	yes
Q9NVH0-2	2

RefSeq proteins (5): NP_001180289, NP_001180290, NP_001180291, NP_001180292, NP_060669 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002562	3’-5’_exonuclease_dom	Domain
IPR012337	RNaseH-like_sf	Homologous_superfamily
IPR036397	RNaseH_sf	Homologous_superfamily
IPR051132	3-5_Exonuclease_domain	Family

Pfam: PF01612

UniProt features (41 total): helix 10, strand 8, mutagenesis site 6, binding site 4, topological domain 2, sequence variant 2, region of interest 2, chain 1, splice variant 1, transmembrane region 1, sequence conflict 1, turn 1, domain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

8 structures.

PDB	Method	Resolution (Å)
6K17	X-RAY DIFFRACTION	1.6
6K19	X-RAY DIFFRACTION	2.2
6K18	X-RAY DIFFRACTION	2.3
6K1C	X-RAY DIFFRACTION	2.45
6K1A	X-RAY DIFFRACTION	2.6
6K1B	X-RAY DIFFRACTION	2.6
6K1E	X-RAY DIFFRACTION	2.9
6K1D	X-RAY DIFFRACTION	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NVH0-F1	80.59	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 110; 246; 108; 108

Mutagenesis-validated functional residues (6):

Position	Phenotype
108–110	loss of 3’-5’ exonuclease activity. impaired ability to stabilize and restart stalled replication forks in response to r
190	abolished exodeoxyribonuclease activity.
195	impaired exonuclease activity.
197	impaired exonuclease activity.
221	impaired exonuclease activity.
226	abolished exonuclease activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 173 (showing top): GOBP_DNA_TEMPLATED_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY, GOMF_RNA_NUCLEASE_ACTIVITY, GOMF_NUCLEASE_ACTIVITY, MODULE_66, MODULE_118, chr14q24, MODULE_379, GOBP_DNA_DAMAGE_RESPONSE, GOCC_MITOCHONDRIAL_ENVELOPE, DOUGLAS_BMI1_TARGETS_DN, MODULE_88, MODULE_242, GOBP_RECOMBINATIONAL_REPAIR, GOMF_EXONUCLEASE_ACTIVITY, FREAC7_01

GO Biological Process (9): double-strand break repair via homologous recombination (GO:0000724), DNA double-strand break processing (GO:0000729), double-strand break repair (GO:0006302), replication fork processing (GO:0031297), nucleic acid metabolic process (GO:0090304), nucleobase-containing compound metabolic process (GO:0006139), DNA repair (GO:0006281), DNA recombination (GO:0006310), DNA damage response (GO:0006974)

GO Molecular Function (13): 3’-5’-RNA exonuclease activity (GO:0000175), magnesium ion binding (GO:0000287), nucleic acid binding (GO:0003676), 3’-5’-DNA exonuclease activity (GO:0008296), single-stranded DNA 3’-5’ DNA exonuclease activity (GO:0008310), 3’-5’ exonuclease activity (GO:0008408), manganese ion binding (GO:0030145), protein homodimerization activity (GO:0042803), nuclease activity (GO:0004518), exonuclease activity (GO:0004527), protein binding (GO:0005515), hydrolase activity (GO:0016787), metal ion binding (GO:0046872)

GO Cellular Component (10): nucleus (GO:0005634), cytoplasm (GO:0005737), mitochondrion (GO:0005739), mitochondrial outer membrane (GO:0005741), mitochondrial matrix (GO:0005759), intermediate filament cytoskeleton (GO:0045111), site of DNA damage (GO:0090734), chromosome (GO:0005694), membrane (GO:0016020), mitochondrial membrane (GO:0031966)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA metabolic process	3
cellular anatomical structure	3
double-strand break repair	2
3’-5’ exonuclease activity	2
binding	2
intracellular membrane-bounded organelle	2
mitochondrion	2
recombinational repair	1
5’-3’ DNA exonuclease activity	1
DNA repair	1
DNA-templated DNA replication maintenance of fidelity	1
nucleobase-containing compound metabolic process	1
macromolecule metabolic process	1
primary metabolic process	1
DNA damage response	1
cellular response to stress	1
RNA exonuclease activity, producing 5’-phosphomonoesters	1
metal ion binding	1
DNA exonuclease activity, producing 5’-phosphomonoesters	1
3’-5’-DNA exonuclease activity	1
single-stranded DNA exodeoxyribonuclease activity	1
exonuclease activity	1
transition metal ion binding	1
identical protein binding	1
protein dimerization activity	1
catalytic activity, acting on a nucleic acid	1
nuclease activity	1
hydrolase activity, acting on ester bonds	1
catalytic activity	1
cation binding	1
intracellular anatomical structure	1
cytoplasm	1
mitochondrial membrane	1
organelle outer membrane	1
intracellular organelle lumen	1
cytoskeleton	1
chromosome	1
intracellular membraneless organelle	1
mitochondrial envelope	1
organelle membrane	1

Protein interactions and networks

STRING

830 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EXD2	TMEM214	Q6NUQ4	917
EXD2	CNOT2	Q9NZN8	898
EXD2	SEC61B	P38390	848
EXD2	EXD1	Q8NHP7	685
EXD2	SEC61G	P38384	684
EXD2	NPR2	P20594	670
EXD2	SEC62	Q99442	670
EXD2	SEC63	Q9UGP8	650
EXD2	TAFAZZIN	Q16635	649
EXD2	SEC61A1	P38378	571
EXD2	EXO1	Q9UQ84	571
EXD2	BRCA1	P38398	562
EXD2	NPPC	P23582	548
EXD2	DNA2	P51530	547
EXD2	WRNIP1	Q96S55	523
EXD2	RBBP8	Q99708	523

IntAct

65 interactions, top by confidence:

A	B	Type	Score
RBBP8	MRE11	psi-mi:“MI:0914”(association)	0.670
ASPH	STXBP3	psi-mi:“MI:0914”(association)	0.640
NME3	NME4	psi-mi:“MI:0914”(association)	0.640
NRAS	RGL2	psi-mi:“MI:0914”(association)	0.550
PEX19	FAM20B	psi-mi:“MI:0914”(association)	0.530
GRAMD2B	EFCAB14	psi-mi:“MI:0914”(association)	0.530
SLC31A1	C2orf72	psi-mi:“MI:0914”(association)	0.530
PEX19	MYO1D	psi-mi:“MI:0914”(association)	0.530
RBBP8	EXD2	psi-mi:“MI:0915”(physical association)	0.500
HTRA2	HAX1	psi-mi:“MI:2364”(proximity)	0.420
EXD2	CLPX	psi-mi:“MI:0915”(physical association)	0.400
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
HIF1AN	CNOT1	psi-mi:“MI:0914”(association)	0.350
EXD2	BRCA1	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
DCTN2	KLHL2	psi-mi:“MI:0914”(association)	0.350
NME3	NME2	psi-mi:“MI:0914”(association)	0.350
EVL	RPL23	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
MAGEA8	METTL15	psi-mi:“MI:0914”(association)	0.350
EVL	PFN2	psi-mi:“MI:0914”(association)	0.350
FAHD1	VWA8	psi-mi:“MI:0914”(association)	0.350

BioGRID (436): EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-Western), RBBP8 (Affinity Capture-Western), BRCA1 (Affinity Capture-Western), MRE11A (Affinity Capture-Western), EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-MS), EXD2 (Affinity Capture-MS)

ESM2 similar proteins: A1YIZ1, A2ARP1, A7Z050, B5DFG1, E1BPN0, E7FCP8, O14976, O18373, O35385, P0C644, P33402, P46489, P49903, P57075, P97364, P97874, Q05145, Q0VC82, Q38A34, Q3V3E1, Q42713, Q43307, Q4Q0M0, Q5R4H0, Q5RDF1, Q5RF87, Q66I14, Q6ESZ9, Q6GL12, Q6PF47, Q6PFW1, Q7Z3D6, Q7ZW38, Q80V31, Q84MA1, Q8BGG7, Q8BH69, Q8BH86, Q8C0D5, Q8H1E2

Diamond homologs: A1CJ18, A2QY39, A4R715, A6RY31, A8WK63, B3LWP6, B3NZ68, B4G5C9, B4I298, B4JF25, B4K934, B4M401, B4N9D3, B4PLB3, B4QUF6, D4ACP5, O09053, O18017, O34748, O88700, O93530, O94761, O94762, P0CQ96, P0CQ97, P15043, P35187, P40724, P46063, P50729, P54132, P71359, P73421, Q09181, Q09811, Q0U7S9, Q0WVW7, Q14191, Q19546, Q1E5R1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 82 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
zinc ion transmembrane transport	6	57.7×	5e-07
intracellular zinc ion homeostasis	6	39.6×	3e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

98 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	87
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2627 predictions. Top by Δscore:

Variant	Effect	Δscore
14:69229014:G:GT	donor_gain	1.0000
14:69230470:A:AG	acceptor_gain	1.0000
14:69230471:G:GG	acceptor_gain	1.0000
14:69230594:ACCAG:A	donor_loss	1.0000
14:69230597:AGG:A	donor_loss	1.0000
14:69230598:GG:G	donor_loss	1.0000
14:69230599:G:GA	donor_loss	1.0000
14:69234901:G:GT	donor_gain	1.0000
14:69234977:G:GT	donor_gain	1.0000
14:69234978:G:T	donor_gain	1.0000
14:69235002:A:T	donor_gain	1.0000
14:69236044:A:AG	acceptor_gain	1.0000
14:69236045:G:GG	acceptor_gain	1.0000
14:69236045:GAAA:G	acceptor_gain	1.0000
14:69236404:A:AG	acceptor_gain	1.0000
14:69236405:A:G	acceptor_gain	1.0000
14:69236406:G:GG	acceptor_gain	1.0000
14:69236406:GA:G	acceptor_gain	1.0000
14:69236543:G:GG	donor_gain	1.0000
14:69236543:GT:G	donor_loss	1.0000
14:69236544:T:G	donor_loss	1.0000
14:69237573:A:AG	acceptor_gain	1.0000
14:69237574:G:GG	acceptor_gain	1.0000
14:69237574:GGAA:G	acceptor_gain	1.0000
14:69237945:G:GT	donor_gain	1.0000
14:69191588:GCAG:G	donor_gain	0.9900
14:69191589:CAGG:C	donor_loss	0.9900
14:69191592:G:GG	donor_gain	0.9900
14:69191592:GTAA:G	donor_loss	0.9900
14:69191593:T:A	donor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000018500 (14:69202876 A>G), RS1000063462 (14:69225168 G>T), RS1000090590 (14:69243294 A>G), RS1000102246 (14:69224426 A>G), RS1000130300 (14:69195947 G>A,T), RS1000180790 (14:69222444 C>T), RS1000182304 (14:69220260 T>A,C,G), RS1000193150 (14:69204344 A>G), RS1000277835 (14:69238202 A>C), RS1000387723 (14:69191411 C>A), RS1000405908 (14:69229265 T>C,G), RS1000536351 (14:69224151 C>T), RS1000671807 (14:69243611 A>G), RS1000724435 (14:69196174 C>A), RS1000790636 (14:69236722 AC>A)

Disease associations

OMIM: gene MIM:616940 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST005232_25	Neuroticism	4.000000e-08
GCST005316_534	Intelligence (MTAG)	5.000000e-09
GCST007709_126	General factor of neuroticism	1.000000e-08
GCST009391_1502	Metabolite levels	8.000000e-06
GCST010002_155	Refractive error	6.000000e-11

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007660	neuroticism measurement
EFO:0004337	intelligence
EFO:0010416	triacylglycerol 52:4 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Ozone	affects cotreatment, increases oxidation, affects expression, increases abundance	2
triphenyl phosphate	affects expression	1
bisphenol A	affects expression	1
sodium arsenate	decreases expression	1
beta-lapachone	increases expression	1
sodium arsenite	increases expression	1
perfluorooctanoic acid	increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation	1
beta-methylcholine	affects expression	1
torcetrapib	increases expression	1
abrine	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, increases oxidation	1
Air Pollutants	affects expression, increases abundance	1
Vehicle Emissions	increases abundance, increases expression	1
Doxorubicin	decreases expression	1
Lead	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Thiram	decreases expression	1
Cadmium Chloride	decreases expression	1
Particulate Matter	increases abundance, increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SM56	HAP1 EXD2 (-) 1	Cancer cell line	Male
CVCL_SM57	HAP1 EXD2 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.