EXOC3-AS1

Summary

EXOC3-AS1 (EXOC3 antisense RNA 1, HGNC:25175) is a long non-coding RNA gene on chromosome 5p15.33.

Predicted to be located in extracellular region.

Source: NCBI Gene 116349 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25175
Approved symbol	EXOC3-AS1
Name	EXOC3 antisense RNA 1
Location	5p15.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000221990
Ensembl biotype	lncRNA
Entrez	116349
RNAcentral	URS00007E3DE9 — lncRNA, 1337 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000623673

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000623673 — 1 exons

Exon	Start	End
ENSE00001572001	441498	443160

Expression profiles

Bgee: expression breadth ubiquitous, 188 present calls, max score 86.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.2723 / max 48.3036, expressed in 1541 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60706	2.2352	1319
60707	1.0371	659

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.15	gold quality
adenohypophysis	UBERON:0002196	79.43	gold quality
buccal mucosa cell	CL:0002336	79.10	silver quality
pituitary gland	UBERON:0000007	77.87	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.23	gold quality
gastrocnemius	UBERON:0001388	76.88	gold quality
right adrenal gland cortex	UBERON:0035827	76.28	gold quality
right adrenal gland	UBERON:0001233	76.04	gold quality
muscle of leg	UBERON:0001383	75.94	gold quality
left adrenal gland	UBERON:0001234	75.20	gold quality
left adrenal gland cortex	UBERON:0035825	75.07	gold quality
anterior cingulate cortex	UBERON:0009835	74.55	gold quality
hypothalamus	UBERON:0001898	74.47	gold quality
adrenal cortex	UBERON:0001235	73.91	gold quality
adrenal gland	UBERON:0002369	73.19	gold quality
amygdala	UBERON:0001876	73.07	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.05	gold quality
prefrontal cortex	UBERON:0000451	72.87	gold quality
stromal cell of endometrium	CL:0002255	72.42	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.35	gold quality
putamen	UBERON:0001874	72.20	gold quality
metanephros cortex	UBERON:0010533	72.20	gold quality
nucleus accumbens	UBERON:0001882	72.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.05	gold quality
right frontal lobe	UBERON:0002810	71.83	gold quality
right testis	UBERON:0004534	71.76	gold quality
heart left ventricle	UBERON:0002084	71.69	gold quality
cerebellar vermis	UBERON:0004720	71.69	silver quality
left testis	UBERON:0004533	71.47	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This study identified 3 novel susceptibility loci and validated 6 previously reported single nucleotide variants for ulcerative colitis through deep resequencing in Koreans and revealed the functional roles of BTNL2 and C5orf55. (PMID:29733354)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.