EXOSC10-AS1

Summary

EXOSC10-AS1 (EXOSC10 antisense RNA 1, HGNC:40456) is a long non-coding RNA gene on chromosome 1p36.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40456
Approved symbol	EXOSC10-AS1
Name	EXOSC10 antisense RNA 1
Location	1p36.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230337
Ensembl biotype	lncRNA
Entrez	105376736
RNAcentral	URS0000A76A99 — lncRNA, 552 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000435388, ENST00000447600, ENST00000452378, ENST00000715289, ENST00000715290, ENST00000715291, ENST00000715292, ENST00000715293, ENST00000715294, ENST00000805051

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000435388 — 2 exons

Exon	Start	End
ENSE00004026450	11101801	11102105
ENSE00004196959	11099427	11099814

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 94.13.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5273 / max 16.2688, expressed in 272 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201348	0.5170	271
613	0.0103	4

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.43	gold quality
colonic epithelium	UBERON:0000397	69.23	silver quality
ventricular zone	UBERON:0003053	68.51	gold quality
bone marrow cell	CL:0002092	68.31	silver quality
mucosa of transverse colon	UBERON:0004991	67.89	gold quality
prefrontal cortex	UBERON:0000451	67.66	gold quality
left testis	UBERON:0004533	67.45	gold quality
putamen	UBERON:0001874	67.28	gold quality
ganglionic eminence	UBERON:0004023	67.18	gold quality
testis	UBERON:0000473	67.07	gold quality
right testis	UBERON:0004534	67.06	gold quality
caudate nucleus	UBERON:0001873	67.00	gold quality
skeletal muscle tissue	UBERON:0001134	66.99	gold quality
frontal cortex	UBERON:0001870	66.26	gold quality
superior frontal gyrus	UBERON:0002661	66.25	gold quality
nucleus accumbens	UBERON:0001882	66.12	gold quality
anterior cingulate cortex	UBERON:0009835	65.81	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.70	gold quality
cerebral cortex	UBERON:0000956	65.66	gold quality
right adrenal gland	UBERON:0001233	65.53	gold quality
right adrenal gland cortex	UBERON:0035827	65.13	gold quality
temporal lobe	UBERON:0001871	65.08	gold quality
amygdala	UBERON:0001876	65.02	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.98	gold quality
Ammon’s horn	UBERON:0001954	64.73	gold quality
right frontal lobe	UBERON:0002810	64.55	gold quality
brain	UBERON:0000955	64.29	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.96	gold quality
hypothalamus	UBERON:0001898	63.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.56

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.