EXTL3-AS1

Summary

EXTL3-AS1 (EXTL3 antisense RNA 1, HGNC:27985) is a long non-coding RNA gene on chromosome 8p21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27985
Approved symbol	EXTL3-AS1
Name	EXTL3 antisense RNA 1
Location	8p21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246339
Ensembl biotype	lncRNA
Entrez	101929402
RNAcentral	URS00000AF6D5 — lncRNA, 780 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000501224, ENST00000519870, ENST00000520023, ENST00000523789, ENST00000656705, ENST00000659934, ENST00000664346, ENST00000784701

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000501224 — 2 exons

Exon	Start	End
ENSE00001966511	28699906	28701319
ENSE00001985497	28696198	28698474

Expression profiles

Bgee: expression breadth ubiquitous, 174 present calls, max score 80.25.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4997 / max 12.5491, expressed in 287 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
92541	0.4997	287

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	80.25	gold quality
buccal mucosa cell	CL:0002336	79.42	gold quality
right testis	UBERON:0004534	78.79	gold quality
adenohypophysis	UBERON:0002196	76.89	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.65	gold quality
testis	UBERON:0000473	76.44	gold quality
right adrenal gland	UBERON:0001233	76.36	gold quality
pituitary gland	UBERON:0000007	75.79	gold quality
right adrenal gland cortex	UBERON:0035827	75.70	gold quality
left adrenal gland cortex	UBERON:0035825	74.07	gold quality
left adrenal gland	UBERON:0001234	74.04	gold quality
right uterine tube	UBERON:0001302	73.53	gold quality
adrenal cortex	UBERON:0001235	72.31	gold quality
adrenal gland	UBERON:0002369	71.24	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.44	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.11	gold quality
endothelial cell	CL:0000115	69.40	silver quality
cerebellar hemisphere	UBERON:0002245	69.27	gold quality
cerebellar cortex	UBERON:0002129	69.17	gold quality
tibial nerve	UBERON:0001323	68.65	gold quality
sural nerve	UBERON:0015488	67.88	gold quality
spinal cord	UBERON:0002240	67.87	gold quality
cerebellum	UBERON:0002037	67.64	gold quality
bone marrow cell	CL:0002092	67.25	silver quality
mucosa of stomach	UBERON:0001199	66.58	gold quality
right lobe of liver	UBERON:0001114	66.36	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.20	gold quality
right frontal lobe	UBERON:0002810	65.17	gold quality
cortical plate	UBERON:0005343	65.14	gold quality
primary visual cortex	UBERON:0002436	65.10	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.37
E-MTAB-9543	no	1.22

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.