EZR-AS1

Summary

EZR-AS1 (EZR antisense RNA 1, HGNC:40609) is a long non-coding RNA gene on chromosome 6q25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40609
Approved symbol	EZR-AS1
Name	EZR antisense RNA 1
Location	6q25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233893
Ensembl biotype	lncRNA
Entrez	101409257
RNAcentral	URS000075E0FC — lncRNA, 362 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000451712

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000451712 — 3 exons

Exon	Start	End
ENSE00001661222	158817979	158818105
ENSE00001778107	158820472	158820593
ENSE00003834829	158822140	158822252

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 84.90.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	84.90	gold quality
bone marrow	UBERON:0002371	77.19	gold quality
colonic epithelium	UBERON:0000397	74.55	gold quality
sural nerve	UBERON:0015488	73.14	gold quality
ganglionic eminence	UBERON:0004023	71.12	gold quality
tonsil	UBERON:0002372	65.81	gold quality
skeletal muscle tissue	UBERON:0001134	62.97	silver quality
granulocyte	CL:0000094	62.71	gold quality
leukocyte	CL:0000738	61.98	gold quality
monocyte	CL:0000576	61.76	gold quality
calcaneal tendon	UBERON:0003701	61.05	gold quality
primary visual cortex	UBERON:0002436	60.80	gold quality
lymph node	UBERON:0000029	60.61	gold quality
prefrontal cortex	UBERON:0000451	59.08	gold quality
islet of Langerhans	UBERON:0000006	58.92	gold quality
vermiform appendix	UBERON:0001154	58.82	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.89	gold quality
blood	UBERON:0000178	57.64	gold quality
cortex of kidney	UBERON:0001225	57.54	gold quality
uterine cervix	UBERON:0000002	57.12	gold quality
liver	UBERON:0002107	57.10	gold quality
urinary bladder	UBERON:0001255	56.74	gold quality
kidney	UBERON:0002113	56.50	gold quality
muscle of leg	UBERON:0001383	56.12	gold quality
placenta	UBERON:0001987	56.08	gold quality
gastrocnemius	UBERON:0001388	54.92	gold quality
stomach	UBERON:0000945	54.86	gold quality
pancreas	UBERON:0001264	54.82	gold quality
adrenal gland	UBERON:0002369	54.82	gold quality
adult mammalian kidney	UBERON:0000082	54.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.62

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Findings suggest that antisense lncRNA EZR-AS1, as a member of an RNA polymerase complex and through enhanced SMYD3-dependent H3K4 methylation, plays an important role in enhancing transcription of the EZR gene to promote the mobility and invasiveness of human cancer cells. (PMID:29253179)
• Long Noncoding RNA EZR-AS1 Regulates the Proliferation, Migration, and Apoptosis of Human Venous Endothelial Cells via SMYD3. (PMID:32596350)
• lncRNA EZRAS1 knockdown represses proliferation, migration and invasion of cSCC via the PI3K/AKT signaling pathway. (PMID:33236153)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.