F11-AS1

Summary

F11-AS1 (F11 antisense RNA 1, HGNC:27725) is a long non-coding RNA gene on chromosome 4q35.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27725
Approved symbol	F11-AS1
Name	F11 antisense RNA 1
Location	4q35.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000251165
Ensembl biotype	lncRNA
Entrez	285441
RNAcentral	URS0000A76B84 — lncRNA, 1861 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000505103, ENST00000508110, ENST00000508287, ENST00000510172, ENST00000657917, ENST00000771881, ENST00000771882, ENST00000771883, ENST00000771884, ENST00000771885, ENST00000771886, ENST00000771887, ENST00000771888

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505103 — 4 exons

Exon	Start	End
ENSE00002033247	186290756	186291032
ENSE00002057814	186288428	186289002
ENSE00002069344	186286094	186286266
ENSE00002071783	186500845	186500997

Expression profiles

Bgee: expression breadth ubiquitous, 150 present calls, max score 95.56.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3650 / max 95.6300, expressed in 71 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
55342	0.3356	71
55343	0.0198	4
55344	0.0096	3

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	95.56	gold quality
right testis	UBERON:0004534	94.29	gold quality
testis	UBERON:0000473	91.43	gold quality
sperm	CL:0000019	81.64	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.22	gold quality
right lobe of liver	UBERON:0001114	75.65	gold quality
oocyte	CL:0000023	71.86	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.54	silver quality
secondary oocyte	CL:0000655	69.51	silver quality
buccal mucosa cell	CL:0002336	68.42	gold quality
right uterine tube	UBERON:0001302	65.14	gold quality
body of pancreas	UBERON:0001150	64.48	gold quality
anterior cingulate cortex	UBERON:0009835	63.80	gold quality
amygdala	UBERON:0001876	63.37	gold quality
right frontal lobe	UBERON:0002810	62.34	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.53	gold quality
pancreas	UBERON:0001264	61.31	gold quality
liver	UBERON:0002107	61.13	gold quality
ganglionic eminence	UBERON:0004023	60.61	gold quality
stromal cell of endometrium	CL:0002255	60.37	gold quality
ventricular zone	UBERON:0003053	60.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.35	gold quality
putamen	UBERON:0001874	58.97	gold quality
nucleus accumbens	UBERON:0001882	58.86	gold quality
adult mammalian kidney	UBERON:0000082	58.46	gold quality
caudate nucleus	UBERON:0001873	58.25	gold quality
gall bladder	UBERON:0002110	57.37	gold quality
neocortex	UBERON:0001950	57.05	gold quality
prefrontal cortex	UBERON:0000451	57.01	gold quality
adult organism	UBERON:0007023	56.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.02

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p. (PMID:31880390)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.