FALEC

Summary

FALEC (focally amplified lncRNA regulator of ECM1, HGNC:43713) is a long non-coding RNA gene on chromosome 1q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43713
Approved symbol	FALEC
Name	focally amplified lncRNA regulator of ECM1
Location	1q21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	ncRNA-a1, FAL1
Ensembl gene	ENSG00000228126
Ensembl biotype	lncRNA
OMIM	616092
Entrez	100874054
RNAcentral	URS00026A2707 — lncRNA, 741 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000416894, ENST00000717990, ENST00000717991, ENST00000718312, ENST00000718313, ENST00000718314, ENST00000823964, ENST00000823965, ENST00000823966

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416894 — 6 exons

Exon	Start	End
ENSE00001615428	150517773	150518120
ENSE00001677463	150515752	150516062
ENSE00004033839	150521333	150521405
ENSE00004033841	150535667	150536788
ENSE00004033844	150532657	150532786
ENSE00004033846	150532250	150532393

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 92.18.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6463 / max 28.1260, expressed in 324 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5125	0.6463	324

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	92.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.44	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.16	gold quality
esophagus mucosa	UBERON:0002469	80.38	gold quality
esophagus	UBERON:0001043	68.47	gold quality
stromal cell of endometrium	CL:0002255	67.14	gold quality
skeletal muscle tissue	UBERON:0001134	66.99	gold quality
sural nerve	UBERON:0015488	66.29	gold quality
cortical plate	UBERON:0005343	66.20	gold quality
ventricular zone	UBERON:0003053	64.56	gold quality
vagina	UBERON:0000996	64.35	gold quality
prefrontal cortex	UBERON:0000451	62.96	gold quality
apex of heart	UBERON:0002098	62.43	gold quality
frontal cortex	UBERON:0001870	61.89	gold quality
ganglionic eminence	UBERON:0004023	61.53	gold quality
calcaneal tendon	UBERON:0003701	61.49	gold quality
superior frontal gyrus	UBERON:0002661	61.21	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.17	gold quality
cerebellum	UBERON:0002037	61.01	gold quality
cerebellar cortex	UBERON:0002129	60.93	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.92	gold quality
ectocervix	UBERON:0012249	60.85	gold quality
cerebellar hemisphere	UBERON:0002245	60.81	gold quality
cerebral cortex	UBERON:0000956	60.76	gold quality
right frontal lobe	UBERON:0002810	60.36	gold quality
nucleus accumbens	UBERON:0001882	60.28	gold quality
anterior cingulate cortex	UBERON:0009835	60.19	gold quality
brain	UBERON:0000955	59.89	gold quality
muscle of leg	UBERON:0001383	59.86	gold quality
islet of Langerhans	UBERON:0000006	59.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 21)

• FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. (PMID:25203321)
• Its oncogenic activity is partially due to its repression of p21. and it may be a potential target for HCC therapy. (PMID:27154519)
• FALEC may promote the progression of Prostate cancer and be a potential diagnostic and therapeutic target in patients with Prostate cancer. (PMID:28585762)
• Overexpression of FAL1 facilitated tumor growth and metastasis by downregulating the PTEN/AKT signaling axis via BMI1. (PMID:28854421)
• this study indicated that lncRNA FAL1 functions as an oncogenic in hepatocellular carcinoma (HCC) and may be a novel diagnostic biomarker or a novel target for the treatment of HCC in future. (PMID:29421439)
• FAL1 expression was significantly upregulated in human osteosarcoma tissues and cell lines compared with their normal controls. lncRNA FAL1 exhibits an important pro-oncogenic effect on osteosarcoma progression by targeting epithelial-mesenchymal transition, which may serve as a potential therapeutic target for osteosarcoma. (PMID:29987852)
• lncRNA FAL1 promotes carcinogenesis of CRC cells via regulation of the miR-637/NUPR1 pathway. (PMID:30267804)
• High FAL1 expression is associated with colon cancer. (PMID:30290064)
• Highly expressed FAL1 can promote proliferation and migration of endothelial cells through activating PTEN/AKT signaling pathway in diabetic atherosclerosis. (PMID:30338819)
• Long non-coding RNA FAL1 regulates apoptosis of esophageal cancer cells via DRP1 and mitochondrial dynamics. (PMID:30501006)
• The overexpression of FAL1 regulates cell proliferation and cell cycle in gastric cancer cells by inhibiting PTEN. (PMID:30556865)
• FALEC was a potential molecular marker used to diagnose cervical cancer and evaluate prognosis (PMID:31248657)
• LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway. (PMID:31298329)
• The focally amplified long non-coding RNA in epithelial cancer (FALEC) was found downregulated in the tissues of tongue squamous cell carcinoma (TSCC) and was predicted to present a good prognosis by bioinformatics analysis. The data revealed that FALEC acted as a tumor suppressor in TSCC and may aid in developing a novel potential therapeutic strategy against TSCC. (PMID:31335317)
• FALEC is overexpressed in endometrial cancer tissues and cells, and involved in regulating cell proliferation and cell-cycle. (PMID:31387003)
• LncRNA FALEC promotes proliferation, migration, and invasion of PTC cells through regulating Wnt/beta-catenin signaling pathway. (PMID:32373973)
• Long non-coding RNA FALEC promotes colorectal cancer progression via regulating miR-2116-3p-targeted PIWIL1. (PMID:33073675)
• LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation. (PMID:36913068)
• Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization. (PMID:37147492)
• LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis. (PMID:37166421)
• CAF-derived exosomal lncRNA FAL1 promotes chemoresistance to oxaliplatin by regulating autophagy in colorectal cancer. (PMID:37400281)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.