FAM131B-AS2

Summary

FAM131B-AS2 (FAM131B antisense RNA 2, HGNC:56141) is a long non-coding RNA gene on chromosome 7q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56141
Approved symbol	FAM131B-AS2
Name	FAM131B antisense RNA 2
Location	7q34
Locus type	RNA, long non-coding
Status	Approved
Aliases	PCAL7
Ensembl gene	ENSG00000232533
Ensembl biotype	lncRNA
Entrez	100507507
RNAcentral	URS0000E60A13 — lncRNA, 1715 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000429630, ENST00000690778, ENST00000841326, ENST00000841327, ENST00000841328

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429630 — 2 exons

Exon	Start	End
ENSE00004265579	143379151	143380109
ENSE00004265580	143380266	143381191

Expression profiles

Bgee: expression breadth ubiquitous, 243 present calls, max score 95.58.

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	95.58	gold quality
smooth muscle tissue	UBERON:0001135	92.27	gold quality
epithelial cell of pancreas	CL:0000083	92.25	silver quality
body of uterus	UBERON:0009853	92.07	gold quality
myometrium	UBERON:0001296	91.98	gold quality
thoracic aorta	UBERON:0001515	90.92	gold quality
descending thoracic aorta	UBERON:0002345	90.90	gold quality
decidua	UBERON:0002450	90.87	gold quality
ascending aorta	UBERON:0001496	90.82	gold quality
leukocyte	CL:0000738	90.41	gold quality
monocyte	CL:0000576	90.39	gold quality
granulocyte	CL:0000094	90.31	gold quality
left uterine tube	UBERON:0001303	89.67	gold quality
superficial temporal artery	UBERON:0001614	89.67	silver quality
left ventricle myocardium	UBERON:0006566	89.21	silver quality
right coronary artery	UBERON:0001625	88.96	gold quality
stromal cell of endometrium	CL:0002255	88.62	gold quality
blood	UBERON:0000178	88.44	gold quality
aorta	UBERON:0000947	88.25	gold quality
saphenous vein	UBERON:0007318	87.83	gold quality
kidney epithelium	UBERON:0004819	87.82	silver quality
pons	UBERON:0000988	87.27	gold quality
cerebellar vermis	UBERON:0004720	87.25	silver quality
muscle layer of sigmoid colon	UBERON:0035805	87.22	gold quality
left coronary artery	UBERON:0001626	87.19	gold quality
coronary artery	UBERON:0001621	87.18	gold quality
lower esophagus	UBERON:0013473	86.77	gold quality
lower esophagus muscularis layer	UBERON:0035833	86.77	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.41	gold quality
uterus	UBERON:0000995	86.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Copy number gain of FAM131B-AS2 promotes the progression of glioblastoma by mitigating replication stress. (PMID:38285005)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.