FAM138B

Summary

FAM138B (family with sequence similarity 138 member B, HGNC:33582) is a long non-coding RNA gene on chromosome 2q14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33582
Approved symbol	FAM138B
Name	family with sequence similarity 138 member B
Location	2q14.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	F379
Ensembl gene	ENSG00000226516
Ensembl biotype	lncRNA
Entrez	654412
RNAcentral	URS00003FB2BC — lncRNA, 1130 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000432583, ENST00000446648, ENST00000801451, ENST00000801452, ENST00000801453, ENST00000801454, ENST00000801455, ENST00000801456, ENST00000801457, ENST00000801458, ENST00000801459, ENST00000801605, ENST00000804107, ENST00000804108, ENST00000804109, ENST00000804110

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000432583 — 2 exons

Exon	Start	End
ENSE00001685902	113577982	113578852
ENSE00002531163	113577382	113577742

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 82.68.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.68	gold quality
skeletal muscle tissue	UBERON:0001134	64.37	silver quality
myometrium	UBERON:0001296	63.33	gold quality
lower esophagus mucosa	UBERON:0035834	62.29	gold quality
body of uterus	UBERON:0009853	61.24	gold quality
urinary bladder	UBERON:0001255	61.13	gold quality
left uterine tube	UBERON:0001303	60.57	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.51	gold quality
lower esophagus	UBERON:0013473	60.41	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.41	gold quality
sural nerve	UBERON:0015488	59.03	silver quality
apex of heart	UBERON:0002098	58.41	gold quality
right uterine tube	UBERON:0001302	58.38	gold quality
cortex of kidney	UBERON:0001225	58.25	gold quality
adult mammalian kidney	UBERON:0000082	58.13	gold quality
fallopian tube	UBERON:0003889	57.91	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.60	gold quality
kidney	UBERON:0002113	57.25	gold quality
tibial nerve	UBERON:0001323	56.77	gold quality
endocervix	UBERON:0000458	55.83	gold quality
endometrium	UBERON:0001295	55.57	gold quality
esophagus	UBERON:0001043	55.47	gold quality
smooth muscle tissue	UBERON:0001135	55.30	gold quality
metanephros cortex	UBERON:0010533	55.11	gold quality
right ovary	UBERON:0002118	55.00	gold quality
omental fat pad	UBERON:0010414	54.77	gold quality
monocyte	CL:0000576	54.72	silver quality
ectocervix	UBERON:0012249	54.36	gold quality
ovary	UBERON:0000992	54.17	gold quality
fundus of stomach	UBERON:0001160	53.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Exosomal linc-FAM138B from cancer cells alleviates hepatocellular carcinoma progression via regulating miR-765. (PMID:33401249)
• LncRNA FAM138B inhibits the progression of non-small cell lung cancer through miR-105-5p. (PMID:36529892)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.