FAM13C
gene geneOn this page
Summary
FAM13C (family with sequence similarity 13 member C, HGNC:19371) is a protein-coding gene on chromosome 10q21.1, encoding Protein FAM13C (Q8NE31).
At a glance
- GWAS associations: 4
- Clinical variants (ClinVar): 87 total
- MANE Select transcript:
NM_198215
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:19371 |
| Approved symbol | FAM13C |
| Name | family with sequence similarity 13 member C |
| Location | 10q21.1 |
| Locus type | gene with protein product |
| Status | Approved |
| Ensembl gene | ENSG00000148541 |
| Ensembl biotype | protein_coding |
| Entrez | 220965 |
Gene structure
Transcript identifiers
Ensembl transcripts: 23 — 14 protein_coding, 4 protein_coding_CDS_not_defined, 3 nonsense_mediated_decay, 2 retained_intron
ENST00000422313, ENST00000435852, ENST00000468696, ENST00000468840, ENST00000470220, ENST00000477101, ENST00000489341, ENST00000503444, ENST00000507568, ENST00000507862, ENST00000510215, ENST00000512919, ENST00000513377, ENST00000611933, ENST00000614220, ENST00000618427, ENST00000618804, ENST00000619059, ENST00000621119, ENST00000622363, ENST00000920262, ENST00000951023, ENST00000951024
RefSeq mRNA: 16 — MANE Select: NM_198215
NM_001001971, NM_001143773, NM_001166698, NM_001347840, NM_001347842, NM_001347843, NM_001347844, NM_001347845, NM_001347846, NM_001347847, NM_001347848, NM_001347849, NM_001347850, NM_001347851, NM_001347852, NM_198215
CCDS: CCDS31207, CCDS44406, CCDS53538, CCDS7255, CCDS86096
Canonical transcript exons
ENST00000618804 — 14 exons
| Exon | Start | End |
|---|---|---|
| ENSE00003471576 | 59302801 | 59302864 |
| ENSE00003512081 | 59268553 | 59268691 |
| ENSE00003514215 | 59264085 | 59264166 |
| ENSE00003516304 | 59262434 | 59262645 |
| ENSE00003530304 | 59251575 | 59251676 |
| ENSE00003554592 | 59252799 | 59252998 |
| ENSE00003571820 | 59323988 | 59324106 |
| ENSE00003594035 | 59269899 | 59270109 |
| ENSE00003609136 | 59355887 | 59355943 |
| ENSE00003641366 | 59352270 | 59352474 |
| ENSE00003646858 | 59283363 | 59283447 |
| ENSE00003673785 | 59254348 | 59254443 |
| ENSE00003716347 | 59246133 | 59247737 |
| ENSE00003738734 | 59362399 | 59362549 |
Expression profiles
Bgee: expression breadth ubiquitous, 252 present calls, max score 97.43.
FANTOM5 (CAGE): breadth broad, TPM avg 6.1554 / max 219.3556, expressed in 725 samples.
FANTOM5 promoters (16 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 109448 | 4.4829 | 681 |
| 109454 | 0.3214 | 93 |
| 109457 | 0.2312 | 90 |
| 109450 | 0.1671 | 100 |
| 109458 | 0.1554 | 90 |
| 109444 | 0.1321 | 48 |
| 109456 | 0.1188 | 65 |
| 109451 | 0.0822 | 50 |
| 109449 | 0.0798 | 50 |
| 109443 | 0.0796 | 52 |
Top tissues by expression
286 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| corpus callosum | UBERON:0002336 | 97.43 | gold quality |
| inferior vagus X ganglion | UBERON:0005363 | 97.11 | gold quality |
| subthalamic nucleus | UBERON:0001906 | 96.33 | gold quality |
| medulla oblongata | UBERON:0001896 | 96.18 | gold quality |
| pons | UBERON:0000988 | 95.91 | gold quality |
| medial globus pallidus | UBERON:0002477 | 95.90 | gold quality |
| superior vestibular nucleus | UBERON:0007227 | 95.56 | gold quality |
| globus pallidus | UBERON:0001875 | 95.36 | gold quality |
| C1 segment of cervical spinal cord | UBERON:0006469 | 95.13 | gold quality |
| endothelial cell | CL:0000115 | 94.67 | gold quality |
| substantia nigra pars reticulata | UBERON:0001966 | 94.60 | gold quality |
| spinal cord | UBERON:0002240 | 94.30 | gold quality |
| substantia nigra pars compacta | UBERON:0001965 | 94.15 | gold quality |
| postcentral gyrus | UBERON:0002581 | 93.66 | gold quality |
| sural nerve | UBERON:0015488 | 93.61 | gold quality |
| ventral tegmental area | UBERON:0002691 | 93.48 | gold quality |
| parietal lobe | UBERON:0001872 | 93.34 | gold quality |
| parietal pleura | UBERON:0002400 | 92.57 | gold quality |
| entorhinal cortex | UBERON:0002728 | 92.07 | gold quality |
| Brodmann (1909) area 23 | UBERON:0013554 | 91.71 | gold quality |
| dorsal plus ventral thalamus | UBERON:0001897 | 91.26 | gold quality |
| lateral globus pallidus | UBERON:0002476 | 91.14 | gold quality |
| superior frontal gyrus | UBERON:0002661 | 91.02 | gold quality |
| temporal lobe | UBERON:0001871 | 90.93 | gold quality |
| amygdala | UBERON:0001876 | 90.73 | gold quality |
| prefrontal cortex | UBERON:0000451 | 90.63 | gold quality |
| Ammon’s horn | UBERON:0001954 | 90.61 | gold quality |
| calcaneal tendon | UBERON:0003701 | 90.49 | gold quality |
| visceral pleura | UBERON:0002401 | 89.94 | gold quality |
| biceps brachii | UBERON:0001507 | 89.53 | gold quality |
Single-cell (SCXA)
Detected in 4 experiment(s), a significant marker in 3.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-CURD-119 | yes | 31.62 |
| E-GEOD-135922 | yes | 29.48 |
| E-ANND-3 | yes | 4.63 |
| E-MTAB-6678 | no | 2.42 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
156 targeting FAM13C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-3163 | 100.00 | 77.23 | 8605 |
| HSA-MIR-4668-3P | 100.00 | 68.74 | 2635 |
| HSA-MIR-9-5P | 100.00 | 72.28 | 2361 |
| HSA-MIR-1277-5P | 100.00 | 73.95 | 5056 |
| HSA-MIR-30A-5P | 100.00 | 76.31 | 3233 |
| HSA-MIR-30B-5P | 100.00 | 76.29 | 3248 |
| HSA-MIR-30C-5P | 100.00 | 76.29 | 3248 |
| HSA-MIR-30D-5P | 100.00 | 76.32 | 3233 |
| HSA-MIR-30E-5P | 100.00 | 76.32 | 3242 |
| HSA-MIR-340-5P | 100.00 | 72.50 | 4437 |
| HSA-MIR-196A-5P | 100.00 | 68.16 | 684 |
| HSA-MIR-5692B | 100.00 | 71.32 | 2622 |
| HSA-MIR-5692C | 100.00 | 71.32 | 2622 |
| HSA-MIR-3646 | 100.00 | 73.56 | 5283 |
| HSA-MIR-196B-5P | 100.00 | 68.16 | 681 |
| HSA-MIR-5692A | 100.00 | 74.40 | 6850 |
| HSA-MIR-223-3P | 99.99 | 70.14 | 1140 |
| HSA-MIR-371B-5P | 99.99 | 75.34 | 4759 |
| HSA-MIR-3667-3P | 99.99 | 67.17 | 1636 |
| HSA-MIR-3662 | 99.99 | 73.82 | 5684 |
| HSA-MIR-548C-3P | 99.99 | 74.01 | 7587 |
| HSA-MIR-513B-5P | 99.99 | 69.96 | 2150 |
| HSA-MIR-568 | 99.98 | 69.86 | 2084 |
| HSA-MIR-520D-5P | 99.98 | 73.34 | 4883 |
| HSA-MIR-524-5P | 99.98 | 73.43 | 4882 |
| HSA-MIR-373-5P | 99.98 | 75.36 | 4753 |
| HSA-MIR-616-5P | 99.98 | 75.58 | 4775 |
| HSA-MIR-607 | 99.97 | 73.62 | 5593 |
| HSA-MIR-3658 | 99.96 | 73.87 | 4379 |
| HSA-MIR-570-3P | 99.96 | 72.41 | 4910 |
Literature-anchored findings (GeneRIF, showing 1)
- the results of our study demonstrate that expression of FAM13C is an independent prognostic marker in prostate cancer. (PMID:28415558)
Cross-species orthologs
3 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| mus_musculus | Fam13c | ENSMUSG00000043259 |
| rattus_norvegicus | Fam13c | ENSRNOG00000000275 |
| drosophila_melanogaster | CG6424 | FBGN0028494 |
Paralogs (2): FAM13B (ENSG00000031003), FAM13A (ENSG00000138640)
Protein
Protein identifiers
Protein FAM13C — Q8NE31 (reviewed: Q8NE31)
All UniProt accessions (8): Q8NE31, A0A087X0M7, A0A087X1H9, A0A087X216, A0A087X2G4, B7Z2K3, D6RIX4, H0YGW3
UniProt curated annotations — full annotation on UniProt →
Similarity. Belongs to the FAM13 family.
Isoforms (5)
| UniProt ID | Names | Canonical? |
|---|---|---|
| Q8NE31-1 | 1 | yes |
| Q8NE31-2 | 2 | |
| Q8NE31-3 | 3 | |
| Q8NE31-4 | 4 | |
| Q8NE31-5 | 5 |
RefSeq proteins (16): NP_001001971, NP_001137245, NP_001160170, NP_001334769, NP_001334771, NP_001334772, NP_001334773, NP_001334774, NP_001334775, NP_001334776, NP_001334777, NP_001334778, NP_001334779, NP_001334780, NP_001334781, NP_937858* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR039102 | FAM13 | Family |
| IPR059029 | FAM13A_dom | Domain |
Pfam: PF26116
UniProt features (20 total): region of interest 6, splice variant 5, modified residue 4, compositionally biased region 3, chain 1, sequence variant 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q8NE31-F1 | 61.67 | 0.24 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Post-translational modifications (4): 131, 238, 385, 386
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 119 (showing top):
GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP, chr10q21, RACCACAR_AML_Q6, MORF_EPHA7, AACTTT_UNKNOWN, RYTTCCTG_ETS2_B, SABATES_COLORECTAL_ADENOMA_DN, AML1_01, CUI_TCF21_TARGETS_2_DN, DBP_Q6, MORF_IL9, MORF_DCC, ETF_Q6, OSF2_Q6, IRF2_01
GO Biological Process (0):
GO Molecular Function (1): protein binding (GO:0005515)
GO Cellular Component (0):
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| binding | 1 |
Protein interactions and networks
STRING
444 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| FAM13C | SRD5A2 | P31213 | 614 |
| FAM13C | AZGP1 | P25311 | 571 |
| FAM13C | GSTM2 | P28161 | 507 |
| FAM13C | SFRP4 | Q6FHJ7 | 507 |
| FAM13C | TPX2 | Q9ULW0 | 506 |
| FAM13C | KLK2 | P20151 | 506 |
| FAM13C | TPM2 | P06468 | 491 |
| FAM13C | FLNC | Q14315 | 479 |
| FAM13C | UMODL1 | Q5DID0 | 472 |
| FAM13C | SDAD1 | Q9NVU7 | 471 |
| FAM13C | CPXM2 | Q8N436 | 452 |
| FAM13C | LGALSL | Q3ZCW2 | 448 |
| FAM13C | MSLNL | Q96KJ4 | 429 |
| FAM13C | FAM131C | Q96AQ9 | 427 |
| FAM13C | ATP5F1E | P56381 | 418 |
| FAM13C | BGN | P13247 | 418 |
IntAct
51 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| FAM13C | KIF2A | psi-mi:“MI:0915”(physical association) | 0.670 |
| FAM13C | CCDC172 | psi-mi:“MI:0915”(physical association) | 0.670 |
| TFIP11 | FAM13C | psi-mi:“MI:0915”(physical association) | 0.670 |
| KIF2A | FAM13C | psi-mi:“MI:0915”(physical association) | 0.670 |
| CCDC172 | FAM13C | psi-mi:“MI:0915”(physical association) | 0.670 |
| FAM13C | TFIP11 | psi-mi:“MI:0915”(physical association) | 0.670 |
| FAM13C | MEOX2 | psi-mi:“MI:0915”(physical association) | 0.560 |
| FAM13C | MTUS2 | psi-mi:“MI:0915”(physical association) | 0.560 |
| FAM13C | HMBOX1 | psi-mi:“MI:0915”(physical association) | 0.560 |
| FAM13C | PHC2 | psi-mi:“MI:0915”(physical association) | 0.560 |
| FAM13C | CEP70 | psi-mi:“MI:0915”(physical association) | 0.560 |
| DVL3 | FAM13C | psi-mi:“MI:0915”(physical association) | 0.560 |
| FAM13C | SDCBP2 | psi-mi:“MI:0915”(physical association) | 0.560 |
| MED4 | FAM13C | psi-mi:“MI:0915”(physical association) | 0.560 |
| MEOX2 | FAM13C | psi-mi:“MI:0915”(physical association) | 0.560 |
| MTUS2 | FAM13C | psi-mi:“MI:0915”(physical association) | 0.560 |
| HMBOX1 | FAM13C | psi-mi:“MI:0915”(physical association) | 0.560 |
| PHC2 | FAM13C | psi-mi:“MI:0915”(physical association) | 0.560 |
| FAM13C | DVL3 | psi-mi:“MI:0915”(physical association) | 0.560 |
| SDCBP2 | FAM13C | psi-mi:“MI:0915”(physical association) | 0.560 |
| FAM13C | MED4 | psi-mi:“MI:0915”(physical association) | 0.560 |
BioGRID (28): FAM13C (Two-hybrid), FAM13C (Two-hybrid), FAM13C (Two-hybrid), FAM13C (Two-hybrid), FAM13C (Two-hybrid), FAM13C (Two-hybrid), FAM13C (Two-hybrid), FAM13C (Two-hybrid), FAM13C (Two-hybrid), FAM13C (Two-hybrid), FAM13C (Two-hybrid), CCDC172 (Two-hybrid), TUBA3C (Affinity Capture-MS), AHCYL2 (Affinity Capture-MS), AHCYL1 (Affinity Capture-MS)
ESM2 similar proteins: A0A5K7RLP0, A1YEX3, A2AGX3, A2AKB4, A7YWH3, A8MVX0, C9JSJ3, O08715, O88286, O88884, P24278, P97303, P97432, Q17RG1, Q1XFL1, Q3KNY0, Q3USH1, Q495C1, Q4V7B1, Q501R9, Q562E2, Q5SYB0, Q5VT97, Q5XIN1, Q6P2K3, Q6PCP7, Q6ZSG2, Q7TSX9, Q80SU3, Q80TL0, Q80W88, Q80XI1, Q8BLK9, Q8BSV3, Q8BW86, Q8K3E9, Q8K451, Q8N7W2, Q8NE31, Q8NFN8
Diamond homologs: A2AB59, A2RUV4, A6X8Z5, A7MB27, B1AUC7, B2RTY4, D2H9U0, E7F3F0, E9Q6X9, F1LQX4, F1LXF1, F4JI46, O14559, O43182, O54834, O94466, O94988, P11274, P15882, P30337, P34288, P42331, P46941, P85298, Q07960, Q10164, Q14CB8, Q17QN0, Q17R89, Q20498, Q2M1Z3, Q3KRB8, Q4LDD4, Q54BP9, Q54FF4, Q54FG5, Q54J98, Q54MV3, Q54TH9, Q54YV1
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
87 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 62 |
| Likely benign | 7 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
2440 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 10:59247735:CTT:C | acceptor_gain | 1.0000 |
| 10:59247738:C:CC | acceptor_gain | 1.0000 |
| 10:59251570:CATA:C | donor_loss | 1.0000 |
| 10:59251571:ATAC:A | donor_loss | 1.0000 |
| 10:59251572:TA:T | donor_loss | 1.0000 |
| 10:59251573:A:C | donor_loss | 1.0000 |
| 10:59251573:ACCTT:A | donor_gain | 1.0000 |
| 10:59251574:C:CA | donor_loss | 1.0000 |
| 10:59251574:CCTTC:C | donor_gain | 1.0000 |
| 10:59251577:T:A | donor_gain | 1.0000 |
| 10:59251672:CAGGC:C | acceptor_gain | 1.0000 |
| 10:59251675:GCC:G | acceptor_loss | 1.0000 |
| 10:59251676:CCT:C | acceptor_loss | 1.0000 |
| 10:59251677:C:A | acceptor_loss | 1.0000 |
| 10:59251677:C:CC | acceptor_gain | 1.0000 |
| 10:59251679:A:C | acceptor_gain | 1.0000 |
| 10:59252797:A:AC | donor_gain | 1.0000 |
| 10:59252798:C:CC | donor_gain | 1.0000 |
| 10:59252847:T:TA | donor_gain | 1.0000 |
| 10:59253015:T:C | acceptor_gain | 1.0000 |
| 10:59253015:T:TC | acceptor_gain | 1.0000 |
| 10:59254346:A:AC | donor_gain | 1.0000 |
| 10:59254347:C:CC | donor_gain | 1.0000 |
| 10:59254347:CAA:C | donor_gain | 1.0000 |
| 10:59254347:CAATT:C | donor_gain | 1.0000 |
| 10:59254442:ACC:A | acceptor_loss | 1.0000 |
| 10:59254443:CCTG:C | acceptor_loss | 1.0000 |
| 10:59254444:C:A | acceptor_loss | 1.0000 |
| 10:59254445:T:A | acceptor_loss | 1.0000 |
| 10:59264167:C:CC | acceptor_gain | 1.0000 |
AlphaMissense
3873 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 10:59247648:A:G | L575P | 1.000 |
| 10:59247660:A:G | L571P | 1.000 |
| 10:59247666:A:G | L569P | 1.000 |
| 10:59247674:T:A | K566N | 1.000 |
| 10:59247674:T:G | K566N | 1.000 |
| 10:59247688:A:G | Y562H | 1.000 |
| 10:59251623:C:G | R529P | 1.000 |
| 10:59251634:C:A | K525N | 1.000 |
| 10:59251634:C:G | K525N | 1.000 |
| 10:59251656:A:G | L518P | 1.000 |
| 10:59251668:A:G | L514P | 1.000 |
| 10:59264165:G:T | P315H | 1.000 |
| 10:59247648:A:T | L575H | 0.999 |
| 10:59247662:T:A | R570S | 0.999 |
| 10:59247662:T:G | R570S | 0.999 |
| 10:59247663:C:G | R570T | 0.999 |
| 10:59247673:C:G | A567P | 0.999 |
| 10:59247675:T:A | K566I | 0.999 |
| 10:59247676:T:C | K566E | 0.999 |
| 10:59247683:C:A | K563N | 0.999 |
| 10:59247683:C:G | K563N | 0.999 |
| 10:59247685:T:C | K563E | 0.999 |
| 10:59247688:A:C | Y562D | 0.999 |
| 10:59247697:A:G | Y559H | 0.999 |
| 10:59247716:C:A | R552S | 0.999 |
| 10:59247716:C:G | R552S | 0.999 |
| 10:59251604:A:C | F535L | 0.999 |
| 10:59251604:A:T | F535L | 0.999 |
| 10:59251606:A:G | F535L | 0.999 |
| 10:59251614:A:G | L532S | 0.999 |
dbSNP variants (sampled 300 via entrez): RS1000029602 (10:59313734 C>A), RS1000061792 (10:59304695 C>A,G,T), RS1000090949 (10:59262779 A>G), RS1000171782 (10:59306782 G>A), RS1000189183 (10:59348780 C>T), RS1000194464 (10:59325612 C>T), RS1000203116 (10:59307124 G>A,C), RS1000242173 (10:59255589 G>A), RS1000251930 (10:59258606 C>T), RS1000288804 (10:59266053 T>G), RS1000291578 (10:59342042 C>A,T), RS1000293139 (10:59255970 T>C,G), RS1000309079 (10:59326265 T>C), RS1000328566 (10:59278843 C>G), RS1000332262 (10:59343304 G>A)
Disease associations
OMIM: gene `` | disease phenotypes:
GenCC curated gene-disease
Mondo (1): prostate cancer (MONDO:0008315)
Orphanet (1): Familial prostate cancer (Orphanet:1331)
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
4 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST001834_9 | Oleic acid (18:1n-9) levels | 5.000000e-06 |
| GCST002932_31 | Manganese levels | 2.000000e-06 |
| GCST003518_34 | Daytime sleep phenotypes | 4.000000e-06 |
| GCST011742_59 | Triglyceride levels in HIV infection | 5.000000e-06 |
EFO canonical traits (2, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0007828 | daytime rest measurement |
| EFO:0004530 | triglyceride measurement |
MeSH disease descriptors (1)
| Descriptor | Name | Tree numbers |
|---|---|---|
| D011471 | Prostatic Neoplasms | C04.588.945.440.770; C12.100.500.260.750; C12.100.500.565.625; C12.200.294.260.750; C12.200.294.565.625; C12.200.758.409.750; C12.900.619.750 |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
CTD chemical–gene interactions
34 total (human), top 30 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Valproic Acid | affects cotreatment, increases expression, decreases expression | 6 |
| Benzo(a)pyrene | affects methylation, decreases expression, increases expression | 4 |
| trichostatin A | affects cotreatment, increases expression | 3 |
| Cyclosporine | decreases expression, increases methylation | 3 |
| mercuric bromide | increases expression, affects cotreatment | 2 |
| Vorinostat | affects cotreatment, increases expression | 2 |
| Panobinostat | affects cotreatment, increases expression | 2 |
| Formaldehyde | decreases expression, increases expression | 2 |
| Phenylmercuric Acetate | affects cotreatment, increases expression | 2 |
| tris(2-butoxyethyl) phosphate | affects expression | 1 |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | affects cotreatment, increases expression | 1 |
| nutlin 3 | affects cotreatment, increases expression | 1 |
| dorsomorphin | affects cotreatment, increases expression | 1 |
| 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine | increases expression, increases response to substance | 1 |
| jinfukang | affects cotreatment, increases expression | 1 |
| Acetaminophen | decreases expression | 1 |
| Cisplatin | increases expression, affects cotreatment | 1 |
| Dactinomycin | affects cotreatment, increases expression | 1 |
| Demecolcine | increases expression | 1 |
| Ethyl Methanesulfonate | increases expression | 1 |
| Gallic Acid | decreases expression | 1 |
| Methyl Methanesulfonate | increases expression | 1 |
| Nickel | decreases expression | 1 |
| Quercetin | decreases expression | 1 |
| Dihydrotestosterone | increases expression | 1 |
| Tetrachlorodibenzodioxin | increases expression | 1 |
| Tobacco Smoke Pollution | decreases expression | 1 |
| Triclosan | decreases expression | 1 |
| Urethane | decreases expression | 1 |
| Vincristine | increases expression | 1 |
Clinical trials (associated diseases)
300 trials via MONDO — disease-level, not drug-specific.
| Trial | Phase | Status | Title |
|---|---|---|---|
| NCT00029224 | PHASE4 | COMPLETED | Treatment With Zoledronic Acid in Patients With Breast Cancer, Multiple Myeloma, and Prostate Cancer With Cancer Related Bone Lesions |
| NCT00035997 | PHASE4 | COMPLETED | Open-label Trial on the Effect of I.V. Zoledronic Acid 4 mg on Bone Density in Hormone Sensitive Prostate Cancer Patients With Bone Metastasis |
| NCT00063609 | PHASE4 | COMPLETED | The Effect of Zoledronic Acid on Bone Loss in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy |
| NCT00103623 | PHASE4 | SUSPENDED | The Plenaxis® Experience Study |
| NCT00106392 | PHASE4 | COMPLETED | A Safety and Efficacy Study of Prograf in the Prevention of Erectile Dysfunction After Radical Prostatectomy |
| NCT00185029 | PHASE4 | UNKNOWN | MR-Lymphography and Lymph Node Staging in Prostate Cancer |
| NCT00199485 | PHASE4 | COMPLETED | Angelica Sinensis for the Treatment of Hot Flashes in Men Undergoing LHRH Therapy for Prostate Cancer |
| NCT00219219 | PHASE4 | COMPLETED | Zoledronic Acid in the Prevention of Skeletal-related Events in Hormone Refractory and Hormone-sensitive Prostate Cancer Patients With Bone Metastases |
| NCT00219271 | PHASE4 | COMPLETED | Effect Of Zoledronic Acid On Circulating And Bone Marrow-Residing Prostate Cancer Cells In Patients With Clinically Localized Prostate Cancer |
| NCT00237146 | PHASE4 | COMPLETED | Study to Evaluate Zoledronic Acid on Quality of Life and Skeletal-related Events as Adjuvant Treatment in Patients With Hormone-naïve Prostate Cancer and Bone Metastasis Who Have Undergone Orchiectomy |
| NCT00242554 | PHASE4 | COMPLETED | Open-label Phase IV Clinical Trial to Evaluate the Safety and Tolerability of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastases |
| NCT00280098 | PHASE4 | COMPLETED | Docetaxel in the Treatment of Hormone Refractory Prostate Cancer |
| NCT00293696 | PHASE4 | COMPLETED | Casodex/Zoladex Biomarkers in Localised Prostate Cancer |
| NCT00334139 | PHASE4 | COMPLETED | Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer |
| NCT00375765 | PHASE4 | COMPLETED | Effects On Dihydrotestosterone Regulated Gene Expression In Benign Prostatic Hyperplasia Or Prostate Cancer |
| NCT00391690 | PHASE4 | COMPLETED | Evaluation of Bone Markers as Diagnostic Tools for Early Detection of Bone Metastases in Patients With High Risk Prostate Cancer |
| NCT00422708 | PHASE4 | COMPLETED | Local Anesthesia for Prostate Biopsy |
| NCT00526331 | PHASE4 | COMPLETED | Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy |
| NCT00590213 | PHASE4 | COMPLETED | Compare the Value of Prophylactic Versus Therapeutic Breast Radiotherapy in CASODEX |
| NCT00629330 | PHASE4 | TERMINATED | Dissemination of Prostate Cancer Screening to PCP’s in African American Communities |
| NCT00771966 | PHASE4 | COMPLETED | Radical Prostatectomy and Perioperative Fluid Therapy |
| NCT00805701 | PHASE4 | COMPLETED | Study Assessing The Efficacy And Safety Of Avodart (Dutasteride) At Improving Urinary Symptoms In Men With Prostate Cancer Who Are Undergoing Seed Implantation |
| NCT00859027 | PHASE4 | COMPLETED | Effect Of Risedronate On Bone Mass In Older Men Receiving Neoadjuvant Therapy For Prostate Cancer |
| NCT00906269 | PHASE4 | UNKNOWN | Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer |
| NCT00953277 | PHASE4 | COMPLETED | Study of Nerve Reconstruction Using AVANCE in Subjects Who Undergo Robotic Assisted Prostatectomy for Treatment of Prostate Cancer |
| NCT00982800 | PHASE4 | COMPLETED | Does Postoperative Gabapentin Reduce Pain, Opioid Consumption and Anxiety and Have a Positive Effect on Health Related Quality of Life After Radical Prostatectomy? |
| NCT01083199 | PHASE4 | COMPLETED | Global Performance Evaluation of the AMS CONTINUUM™ Device |
| NCT01136226 | PHASE4 | COMPLETED | Evaluate Recovery of Testosterone for Patients Using Eligard |
| NCT01161563 | PHASE4 | COMPLETED | Randomized Crossover Trial to Assess the Tolerability of Gonadotropin Releasing Hormone (GnRH) Analogue Administration |
| NCT01230905 | PHASE4 | COMPLETED | Study to Monitor the Effects of Androgen Suppression Treatment on the Heart |
| NCT01296672 | PHASE4 | COMPLETED | 3 Month Finasteride Challenge Test Can Significantly Improve the Performance of Screening for Prostate Cancer |
| NCT01365143 | PHASE4 | TERMINATED | Prospective Randomized Trial Comparing Robotic Versus Open Radical Prostatectomy |
| NCT01379742 | PHASE4 | UNKNOWN | Comparison of Between ThinSeed™ and OncoSeed™ for Permanent Prostate Brachytherapy |
| NCT01486563 | PHASE4 | COMPLETED | Hydroxyethyl Starch and Renal Function After Radical Prostatectomy |
| NCT01511874 | PHASE4 | COMPLETED | Efficacy and Safety Study of ELIGARD 22.5mg With Prostate Cancer |
| NCT01512472 | PHASE4 | TERMINATED | Firmagon (Degarelix) Intermittent Therapy |
| NCT01547416 | PHASE4 | COMPLETED | The Effect of Combined General/Epidural Anesthesia Versus General Anesthesia on Diaphragmatic Function |
| NCT01571544 | PHASE4 | COMPLETED | The Use of Thermal Suits as Preventing Hypothermia During Surgery |
| NCT01581749 | PHASE4 | UNKNOWN | Evaluation of Truebeam for Low-Intermediate Risk Prostate Cancer |
| NCT01649635 | PHASE4 | COMPLETED | Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.