FAM151A

Summary

FAM151A (family with sequence similarity 151 member A, HGNC:25032) is a protein-coding gene on chromosome 1p32.3, encoding Protein FAM151A (Q8WW52).

Located in extracellular exosome. Implicated in colorectal adenocarcinoma.

Source: NCBI Gene 338094 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 8 total
• MANE Select transcript: NM_176782

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25032
Approved symbol	FAM151A
Name	family with sequence similarity 151 member A
Location	1p32.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC27169
Ensembl gene	ENSG00000162391
Ensembl biotype	protein_coding
Entrez	338094

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000302250, ENST00000371304, ENST00000877511, ENST00000877512, ENST00000877513

RefSeq mRNA: 1 — MANE Select: NM_176782 NM_176782

CCDS: CCDS594

Canonical transcript exons

ENST00000302250 — 8 exons

Exon	Start	End
ENSE00001064698	54616020	54616172
ENSE00001064699	54612486	54612710
ENSE00001064702	54614700	54614859
ENSE00001064704	54619864	54620007
ENSE00001139972	54610412	54610555
ENSE00001139980	54611606	54611745
ENSE00001156805	54609181	54609941
ENSE00003848632	54623278	54623525

Expression profiles

Bgee: expression breadth ubiquitous, 141 present calls, max score 91.85.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2653 / max 69.1575, expressed in 66 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12472	0.1874	59
12471	0.0779	17

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	91.85	gold quality
adult organism	UBERON:0007023	90.75	gold quality
kidney	UBERON:0002113	84.78	gold quality
small intestine Peyer’s patch	UBERON:0003454	84.56	gold quality
small intestine	UBERON:0002108	80.00	gold quality
right lobe of liver	UBERON:0001114	78.08	gold quality
cortex of kidney	UBERON:0001225	77.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.42	gold quality
mucosa of transverse colon	UBERON:0004991	76.44	gold quality
apex of heart	UBERON:0002098	74.91	gold quality
liver	UBERON:0002107	74.38	gold quality
metanephros cortex	UBERON:0010533	73.09	gold quality
heart left ventricle	UBERON:0002084	71.28	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.78	gold quality
cardiac ventricle	UBERON:0002082	70.24	gold quality
lymph node	UBERON:0000029	69.16	gold quality
rectum	UBERON:0001052	67.89	gold quality
transverse colon	UBERON:0001157	67.46	gold quality
lower esophagus mucosa	UBERON:0035834	66.72	gold quality
renal medulla	UBERON:0000362	65.06	gold quality
metanephros	UBERON:0000081	64.63	gold quality
heart	UBERON:0000948	64.27	gold quality
intestine	UBERON:0000160	63.07	gold quality
right atrium auricular region	UBERON:0006631	62.48	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.45	gold quality
cardiac atrium	UBERON:0002081	61.92	gold quality
colonic epithelium	UBERON:0000397	61.00	gold quality
right lobe of thyroid gland	UBERON:0001119	59.72	gold quality
colon	UBERON:0001155	58.08	gold quality
large intestine	UBERON:0000059	57.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.63

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	fam151a	ENSDARG00000058218
mus_musculus	Fam151a	ENSMUSG00000034871
rattus_norvegicus	Fam151a	ENSRNOG00000007799
drosophila_melanogaster	CG7231	FBGN0031968
caenorhabditis_elegans		WBGENE00012184

Paralogs (1): FAM151B (ENSG00000152380)

Protein

Protein identifiers

Protein FAM151A — Q8WW52 (reviewed: Q8WW52)

All UniProt accessions (1): Q8WW52

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the menorin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8WW52-1	1	yes
Q8WW52-2	2

RefSeq proteins (1): NP_788954* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019356	Menorin_dom	Domain

Pfam: PF10223

UniProt features (10 total): sequence variant 6, chain 1, transmembrane region 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WW52-F1	92.08	0.77

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 27 (showing top): ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, SUPT16H_TARGET_GENES, ZNF7_TARGET_GENES, GSE15324_ELF4_KO_VS_WT_NAIVE_CD8_TCELL_DN, GSE15930_STIM_VS_STIM_AND_IL12_24H_CD8_T_CELL_DN, GSE15930_STIM_VS_STIM_AND_IL12_72H_CD8_T_CELL_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_UP, GSE17721_PAM3CSK4_VS_CPG_16H_BMDC_UP, DESCARTES_FETAL_LIVER_HEPATOBLASTS, CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_DN, GSE2826_WT_VS_XID_BCELL_DN, GSE29615_CTRL_VS_DAY7_LAIV_FLU_VACCINE_PBMC_DN, ZHANG_FH_DEFICIENT_RCC_TUMOR_VS_NORMAL_DN, KONIGORSKI_INCREASED_SUBCUTANEOUS_ADIPOSE_TISSUE_MASS_UP, GSE32423_CTRL_VS_IL7_MEMORY_CD8_TCELL_UP

GO Biological Process (1): biological_process (GO:0008150)

GO Molecular Function (1): molecular_function (GO:0003674)

GO Cellular Component (3): obsolete extracellular space (GO:0005615), membrane (GO:0016020), extracellular exosome (GO:0070062)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1
extracellular vesicle	1

Protein interactions and networks

STRING

288 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FAM151A	CRB2	Q5IJ48	456
FAM151A	PLEKHH3	Q7Z736	454
FAM151A	FETUB	Q9UGM5	421
FAM151A	DCAF8L2	P0C7V8	399
FAM151A	FAM174C	Q9BVV8	393
FAM151A	TMEM213	A2RRL7	367
FAM151A	ADA2	Q9NZK5	367
FAM151A	ARL14	Q8N4G2	364
FAM151A	STOX2	Q9P2F5	364
FAM151A	CASZ1	Q86V15	347
FAM151A	KCNH4	Q9UQ05	342
FAM151A	SHF	Q7M4L6	314
FAM151A	KRT24	Q2M2I5	310
FAM151A	CDH16	O75309	296
FAM151A	SLC6A12	P48065	292

IntAct

5 interactions, top by confidence:

A	B	Type	Score
CD81	STX3	psi-mi:“MI:0914”(association)	0.350
CD81	PVR	psi-mi:“MI:0914”(association)	0.350
CD81	CD276	psi-mi:“MI:0914”(association)	0.350

BioGRID (1): APP (Reconstituted Complex)

ESM2 similar proteins: A0A5F8AH41, A0AVI4, A7S641, O75843, P10937, P25235, P40935, P70345, Q06AU9, Q08DJ7, Q08DK0, Q0IJ33, Q14AI0, Q28647, Q28CM7, Q3V3N7, Q4R7D0, Q503C8, Q5FVF4, Q5R5N9, Q5RDY9, Q5XIL6, Q5ZI25, Q68F70, Q6IR55, Q6NWH5, Q6PD82, Q74ZJ1, Q7KNA0, Q7QIL2, Q80YU0, Q8CHY3, Q8CIM8, Q8IV36, Q8K304, Q8MRQ4, Q8NFJ9, Q8R1F6, Q8R307, Q8WW52

Diamond homologs: A5PN38, D3YUE4, Q5RDY9, Q642A7, Q6UXP7, Q8QZW3, Q8WW52, O45879

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

8 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	5
Likely benign	1
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1550 predictions. Top by Δscore:

Variant	Effect	Δscore
1:54609942:C:CC	acceptor_gain	1.0000
1:54609953:G:T	acceptor_gain	1.0000
1:54610556:C:CC	acceptor_gain	1.0000
1:54611599:T:A	donor_gain	1.0000
1:54611600:CCTTA:C	donor_loss	1.0000
1:54611602:TTAC:T	donor_loss	1.0000
1:54611603:TACA:T	donor_loss	1.0000
1:54611604:A:AC	donor_gain	1.0000
1:54611604:A:AT	donor_loss	1.0000
1:54611604:ACAGG:A	donor_gain	1.0000
1:54611605:C:CA	donor_gain	1.0000
1:54611605:CAGG:C	donor_gain	1.0000
1:54611605:CAGGC:C	donor_gain	1.0000
1:54611618:TGA:T	donor_gain	1.0000
1:54611743:TAC:T	acceptor_gain	1.0000
1:54611746:CT:C	acceptor_loss	1.0000
1:54612622:T:TA	donor_gain	1.0000
1:54612708:AACC:A	acceptor_loss	1.0000
1:54612711:C:CC	acceptor_gain	1.0000
1:54612711:CT:C	acceptor_loss	1.0000
1:54614693:CACTC:C	donor_loss	1.0000
1:54614694:ACTCA:A	donor_loss	1.0000
1:54614695:CTCAC:C	donor_loss	1.0000
1:54614696:TCACT:T	donor_loss	1.0000
1:54614697:CA:C	donor_loss	1.0000
1:54614698:A:AC	donor_gain	1.0000
1:54614699:C:CA	donor_gain	1.0000
1:54614699:CT:C	donor_gain	1.0000
1:54614699:CTG:C	donor_gain	1.0000
1:54614699:CTGT:C	donor_gain	1.0000

AlphaMissense

3765 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:54614852:T:A	K141N	0.983
1:54614852:T:G	K141N	0.983
1:54612658:A:G	W210R	0.982
1:54612658:A:T	W210R	0.982
1:54616053:A:G	W128R	0.982
1:54616053:A:T	W128R	0.982
1:54614846:G:C	D143E	0.981
1:54614846:G:T	D143E	0.981
1:54614843:G:C	F144L	0.979
1:54614843:G:T	F144L	0.979
1:54614845:A:G	F144L	0.979
1:54612554:G:C	F244L	0.978
1:54612554:G:T	F244L	0.978
1:54612556:A:G	F244L	0.978
1:54612555:A:G	F244S	0.977
1:54612707:G:C	F193L	0.977
1:54612707:G:T	F193L	0.977
1:54612709:A:G	F193L	0.977
1:54614764:A:G	W171R	0.975
1:54614764:A:T	W171R	0.975
1:54614840:C:A	K145N	0.974
1:54614840:C:G	K145N	0.974
1:54619912:A:G	W72R	0.973
1:54619912:A:T	W72R	0.973
1:54614844:A:G	F144S	0.972
1:54611739:G:C	S269R	0.970
1:54611739:G:T	S269R	0.970
1:54611741:T:G	S269R	0.970
1:54612708:A:G	F193S	0.970
1:54616152:C:G	A95P	0.970

dbSNP variants (sampled 300 via entrez): RS1000138150 (1:54623836 G>A), RS1000157062 (1:54623509 C>G,T), RS1000687442 (1:54616687 T>C), RS1000731408 (1:54608690 C>G,T), RS1000753654 (1:54614242 G>A), RS1000767734 (1:54617946 C>A,T), RS1001036633 (1:54616546 G>A,C), RS1001101500 (1:54622475 G>C), RS1001282266 (1:54610005 C>T), RS1001438080 (1:54620739 C>A,T), RS1001551040 (1:54621099 G>T), RS1001761573 (1:54615262 TAG>T), RS1001851491 (1:54610079 G>A), RS1002159479 (1:54621318 G>A), RS1002212572 (1:54615523 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006585_805	Blood protein levels	2.000000e-22

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression	3
Aflatoxin B1	decreases expression, increases methylation	3
lasiocarpine	decreases expression	1
methyleugenol	decreases expression	1
pirinixic acid	affects binding, increases activity, increases expression	1
terbufos	increases methylation	1
sodium arsenite	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, increases expression	1
Fonofos	increases methylation	1
Estradiol	decreases expression	1
Hydrogen Peroxide	affects expression	1
Lipopolysaccharides	affects cotreatment, increases expression	1
N-Nitrosopyrrolidine	decreases expression	1
Parathion	increases methylation	1
Tetrachlorodibenzodioxin	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Okadaic Acid	decreases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.