FAM153B

Summary

FAM153B (family with sequence similarity 153 member B, HGNC:27323) is a protein-coding gene on chromosome 5q35.2, encoding Protein FAM153B (P0C7A2).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27323
Approved symbol	FAM153B
Name	family with sequence similarity 153 member B
Location	5q35.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000182230
Entrez	202134

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 171 present calls, max score 94.96.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0732 / max 14.3536, expressed in 33 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
203802	0.0732	33

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	94.96	gold quality
left testis	UBERON:0004533	94.70	gold quality
right uterine tube	UBERON:0001302	92.22	gold quality
buccal mucosa cell	CL:0002336	92.01	gold quality
testis	UBERON:0000473	91.61	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.35	gold quality
cerebellar hemisphere	UBERON:0002245	89.57	gold quality
cerebellar cortex	UBERON:0002129	89.52	gold quality
mucosa of stomach	UBERON:0001199	88.74	gold quality
cerebellum	UBERON:0002037	88.71	gold quality
left ovary	UBERON:0002119	88.64	gold quality
oviduct epithelium	UBERON:0004804	86.54	gold quality
adenohypophysis	UBERON:0002196	85.96	gold quality
right ovary	UBERON:0002118	85.42	gold quality
spleen	UBERON:0002106	84.76	gold quality
pituitary gland	UBERON:0000007	84.59	gold quality
sperm	CL:0000019	84.23	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.12	gold quality
ovary	UBERON:0000992	83.84	gold quality
right frontal lobe	UBERON:0002810	83.33	gold quality
anterior cingulate cortex	UBERON:0009835	79.97	gold quality
right adrenal gland cortex	UBERON:0035827	78.95	gold quality
fallopian tube	UBERON:0003889	78.39	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.37	gold quality
right adrenal gland	UBERON:0001233	77.77	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	77.64	gold quality
left adrenal gland cortex	UBERON:0035825	77.22	gold quality
left adrenal gland	UBERON:0001234	77.05	gold quality
primary visual cortex	UBERON:0002436	76.73	gold quality
nucleus accumbens	UBERON:0001882	76.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.53

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Protein FAM153B — P0C7A2 (reviewed: P0C7A2)

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the FAM153 family.

Isoforms (2)

UniProt ID	Names	Canonical?
P0C7A2-1	1	yes
P0C7A2-2	2

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR023249	FAM153	Family

Pfam: PF15722

UniProt features (7 total): compositionally biased region 3, region of interest 2, chain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C7A2-F1	50.76	0.03

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

188 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FAM153B	ANKRD45	Q5TZF3	480
FAM153B	SIMC1	Q8NDZ2	479
FAM153B	CFAP206	Q8IYR0	470
FAM153B	ASPHD2	Q6ICH7	447
FAM153B	GLT1D1	Q96MS3	419
FAM153B	TRHR	P34981	396
FAM153B	RAD9B	Q6WBX8	380
FAM153B	LRRC73	Q5JTD7	376
FAM153B	ZNF326	Q5BKZ1	359
FAM153B	TSPAN4	O14817	330
FAM153B	KCNH3	Q9ULD8	326
FAM153B	OR4C46	A6NHA9	314
FAM153B	GNG3	P29798	311
FAM153B	SLC35A1	P78382	311
FAM153B	CACNA1B	Q00975	305

IntAct

4 interactions, top by confidence:

A	B	Type	Score
FAM153B	FAM153A	psi-mi:“MI:0914”(association)	0.350
FAM153B	TYW5	psi-mi:“MI:0914”(association)	0.350
FAM153B	A2ML1	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A0A0J9YWL9, A0A0J9YY54, A0A1B0GV03, A6NEF3, A6NEM1, A6NI86, A8MZA4, B4DH59, D3YVF0, F6QRE9, H0YKK7, H0YM25, P0C6Y7, P0C7A2, P0DX00, P0DX01, P0DX02, P14590, P21263, P22793, P24587, P24710, P48997, P48998, Q07283, Q0II65, Q0P6D6, Q13342, Q3BBV2, Q4R9C9, Q5W0A0, Q6AXX0, Q6NSX1, Q6P5H2, Q6P902, Q86T75, Q8CHD8, Q8N2N9, Q8N660, Q8N7Z2

Diamond homologs: P0C7A2, Q9UHL3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000018509 (5:176097268 A>G), RS1000372860 (5:176113006 G>A), RS1000420890 (5:176123033 G>A), RS1000450537 (5:176123901 C>T), RS1000756172 (5:176121593 T>C), RS1000785379 (5:176121838 AC>A), RS1000843959 (5:176083433 C>T), RS1000975055 (5:176072450 C>G,T), RS1001050287 (5:176073784 G>A), RS1001217964 (5:176080883 C>G,T), RS1001276156 (5:176083590 G>A,T), RS1001313453 (5:176067139 A>G), RS1001585721 (5:176080724 A>C), RS1001626245 (5:176091596 G>A), RS1001638988 (5:176109018 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

15 total (human), top 15 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Silicon Dioxide	decreases expression	2
Aflatoxin B1	decreases expression, increases methylation	2
testosterone undecanoate	affects cotreatment, decreases expression	1
butyraldehyde	decreases expression	1
monomethylpropion	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
ICG 001	increases expression	1
bisphenol S	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Polycyclic Aromatic Hydrocarbons	decreases expression, increases abundance, affects cotreatment	1
Tobacco Smoke Pollution	decreases expression	1
Levonorgestrel	affects cotreatment, decreases expression	1
1-Butanol	affects cotreatment, decreases expression, increases abundance	1
Particulate Matter	affects cotreatment, decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.