FAM157B

Summary

FAM157B (family with sequence similarity 157 member B, HGNC:34080) is a unprocessed pseudogene on chromosome 9q34.3.

At a glance

• Gene type: non-coding (transcribed_unprocessed_pseudogene) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34080
Approved symbol	FAM157B
Name	family with sequence similarity 157 member B
Location	9q34.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233013
Ensembl biotype	transcribed_unprocessed_pseudogene
Entrez	100132403
RNAcentral	URS0000ABD89A — lncRNA, 3690 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 transcribed_unprocessed_pseudogene

ENST00000639350

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000639350 — 4 exons

Exon	Start	End
ENSE00002337959	138243620	138243729
ENSE00002356571	138249315	138249380
ENSE00003809771	138252689	138252792
ENSE00003810982	138253140	138253217

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 91.40.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5958 / max 66.6742, expressed in 115 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
99719	0.5958	115

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	91.40	gold quality
monocyte	CL:0000576	81.52	gold quality
leukocyte	CL:0000738	80.94	gold quality
bone marrow cell	CL:0002092	80.52	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.37	gold quality
bone marrow	UBERON:0002371	78.98	gold quality
granulocyte	CL:0000094	76.18	gold quality
vermiform appendix	UBERON:0001154	72.37	gold quality
spleen	UBERON:0002106	70.89	gold quality
esophagus mucosa	UBERON:0002469	66.16	gold quality
upper lobe of left lung	UBERON:0008952	66.12	gold quality
right lung	UBERON:0002167	63.39	gold quality
lung	UBERON:0002048	60.67	gold quality
mucosa of stomach	UBERON:0001199	60.53	gold quality
descending thoracic aorta	UBERON:0002345	58.90	gold quality
tonsil	UBERON:0002372	58.62	gold quality
testis	UBERON:0000473	57.51	gold quality
left uterine tube	UBERON:0001303	57.48	gold quality
apex of heart	UBERON:0002098	57.40	gold quality
left testis	UBERON:0004533	56.10	gold quality
urinary bladder	UBERON:0001255	55.68	gold quality
right testis	UBERON:0004534	55.54	gold quality
right coronary artery	UBERON:0001625	55.41	gold quality
esophagus	UBERON:0001043	55.40	gold quality
gall bladder	UBERON:0002110	55.16	gold quality
placenta	UBERON:0001987	54.86	gold quality
omental fat pad	UBERON:0010414	53.69	gold quality
liver	UBERON:0002107	53.37	gold quality
vagina	UBERON:0000996	53.04	gold quality
minor salivary gland	UBERON:0001830	52.98	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9801	yes	8.89
E-ANND-3	no	1.56

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.