FAM157C

Summary

FAM157C (family with sequence similarity 157 member C, HGNC:34081) is a long non-coding RNA gene on chromosome 16q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34081
Approved symbol	FAM157C
Name	family with sequence similarity 157 member C
Location	16q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000260528
Ensembl biotype	lncRNA
Entrez	100996541
RNAcentral	URS00007E49F7 — lncRNA, 961 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 63 — 63 lncRNA

ENST00000563357, ENST00000565635, ENST00000566864, ENST00000566898, ENST00000568070, ENST00000568418, ENST00000568739, ENST00000568947, ENST00000569162, ENST00000570230, ENST00000656587, ENST00000658135, ENST00000660047, ENST00000660257, ENST00000660322, ENST00000663101, ENST00000663757, ENST00000663989, ENST00000665776, ENST00000667258, ENST00000668039, ENST00000668099, ENST00000669853, ENST00000691845, ENST00000715692, ENST00000833276, ENST00000833278, ENST00000833279, ENST00000833282, ENST00000833283, ENST00000833284, ENST00000833285, ENST00000833286, ENST00000833287, ENST00000833288, ENST00000833289, ENST00000833290, ENST00000833291, ENST00000833292, ENST00000833293, ENST00000833294, ENST00000833295, ENST00000833296, ENST00000833297, ENST00000833298, ENST00000833299, ENST00000833300, ENST00000833301, ENST00000833302, ENST00000833303, ENST00000833304, ENST00000833305, ENST00000833306, ENST00000833307, ENST00000833308, ENST00000833309, ENST00000833310, ENST00000833311, ENST00000833312, ENST00000833313, ENST00000833314, ENST00000833315, ENST00000833316

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563357 — 9 exons

Exon	Start	End
ENSE00002579269	90128623	90128732
ENSE00002585912	90134319	90134384
ENSE00002586965	90116288	90116483
ENSE00002592923	90137686	90137993
ENSE00002599166	90106159	90106705
ENSE00002602990	90129797	90129928
ENSE00002615273	90102271	90102442
ENSE00002615604	90136542	90136600
ENSE00002624945	90133219	90133434

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 96.25.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7584 / max 64.2028, expressed in 138 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155690	0.7584	138

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	96.25	gold quality
bone marrow cell	CL:0002092	93.53	gold quality
bone marrow	UBERON:0002371	93.41	gold quality
monocyte	CL:0000576	91.73	gold quality
leukocyte	CL:0000738	90.88	gold quality
granulocyte	CL:0000094	89.27	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.34	gold quality
vermiform appendix	UBERON:0001154	87.78	gold quality
sural nerve	UBERON:0015488	86.02	gold quality
spleen	UBERON:0002106	85.00	gold quality
right lung	UBERON:0002167	84.98	gold quality
esophagus mucosa	UBERON:0002469	84.89	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.09	gold quality
upper lobe of left lung	UBERON:0008952	83.81	gold quality
apex of heart	UBERON:0002098	83.58	gold quality
superior frontal gyrus	UBERON:0002661	83.44	gold quality
mucosa of stomach	UBERON:0001199	83.22	gold quality
primary visual cortex	UBERON:0002436	83.10	gold quality
testis	UBERON:0000473	82.27	gold quality
right testis	UBERON:0004534	82.15	gold quality
lower esophagus mucosa	UBERON:0035834	81.95	gold quality
body of pancreas	UBERON:0001150	81.80	gold quality
left testis	UBERON:0004533	81.44	gold quality
lung	UBERON:0002048	81.40	gold quality
minor salivary gland	UBERON:0001830	81.34	gold quality
cerebellum	UBERON:0002037	81.24	gold quality
cerebellar cortex	UBERON:0002129	81.13	gold quality
saliva-secreting gland	UBERON:0001044	81.02	gold quality
cerebellar hemisphere	UBERON:0002245	81.01	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA FAM157C contributes to clonal proliferation in paroxysmal nocturnal hemoglobinuria. (PMID:36607351)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.