FAM161B

Summary

FAM161B (FAM161 centrosomal protein B, HGNC:19854) is a protein-coding gene on chromosome 14q24.3, encoding Protein FAM161B (Q96MY7).

Predicted to be involved in cilium organization. Located in cytoplasmic microtubule.

Source: NCBI Gene 145483 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 125 total
• MANE Select transcript: NM_152445

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19854
Approved symbol	FAM161B
Name	FAM161 centrosomal protein B
Location	14q24.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ31697
Ensembl gene	ENSG00000156050
Ensembl biotype	protein_coding
Entrez	145483

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000286544, ENST00000556794, ENST00000651776

RefSeq mRNA: 1 — MANE Select: NM_152445 NM_152445

CCDS: CCDS9822

Canonical transcript exons

ENST00000286544 — 9 exons

Exon	Start	End
ENSE00001024217	73944335	73944885
ENSE00001024221	73942369	73942715
ENSE00001024225	73946286	73946605
ENSE00001097676	73937948	73938112
ENSE00001097681	73940926	73941053
ENSE00001197269	73932276	73934394
ENSE00003548439	73937602	73937701
ENSE00003549684	73935949	73936088
ENSE00003894712	73949973	73950094

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 99.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.8308 / max 51.5968, expressed in 1436 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
144004	2.7899	1225
144003	0.5704	283
144005	0.4570	204
144006	0.0136	3

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	99.72	silver quality
renal medulla	UBERON:0000362	99.49	gold quality
cardia of stomach	UBERON:0001162	99.48	silver quality
ventral tegmental area	UBERON:0002691	99.43	gold quality
pylorus	UBERON:0001166	99.40	gold quality
medulla oblongata	UBERON:0001896	99.31	gold quality
trigeminal ganglion	UBERON:0001675	99.30	gold quality
nipple	UBERON:0002030	99.26	gold quality
substantia nigra pars compacta	UBERON:0001965	99.24	gold quality
superior surface of tongue	UBERON:0007371	99.24	gold quality
inferior vagus X ganglion	UBERON:0005363	99.23	gold quality
subthalamic nucleus	UBERON:0001906	99.22	gold quality
superior vestibular nucleus	UBERON:0007227	99.22	gold quality
lateral globus pallidus	UBERON:0002476	99.20	gold quality
dorsal root ganglion	UBERON:0000044	99.19	gold quality
trachea	UBERON:0003126	99.18	gold quality
substantia nigra pars reticulata	UBERON:0001966	99.17	gold quality
dorsal plus ventral thalamus	UBERON:0001897	99.15	gold quality
lateral nuclear group of thalamus	UBERON:0002736	99.07	gold quality
upper arm skin	UBERON:0004263	99.06	gold quality
sperm	CL:0000019	98.99	gold quality
urethra	UBERON:0000057	98.93	gold quality
pericardium	UBERON:0002407	98.88	gold quality
penis	UBERON:0000989	98.77	gold quality
pons	UBERON:0000988	98.68	gold quality
saphenous vein	UBERON:0007318	98.66	gold quality
pharyngeal mucosa	UBERON:0000355	98.65	silver quality
synovial joint	UBERON:0002217	98.63	gold quality
tongue	UBERON:0001723	98.59	gold quality
body of tongue	UBERON:0011876	98.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.59

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

42 targeting FAM161B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-4799-5P	99.82	70.60	2663
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-486-5P	99.51	70.39	707
HSA-MIR-5571-5P	99.49	66.99	1764
HSA-MIR-6165	99.44	67.12	1389
HSA-MIR-569	99.42	66.32	1009
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-4263	99.18	69.25	2236
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-934	98.49	70.44	581
HSA-MIR-5089-5P	98.45	66.06	1388
HSA-MIR-1199-5P	98.44	66.51	829
HSA-MIR-6751-3P	98.44	66.35	835
HSA-MIR-7156-3P	98.25	67.66	859
HSA-MIR-10395-3P	98.10	66.70	1726
HSA-MIR-6842-3P	98.07	66.33	1325
HSA-MIR-204-3P	97.80	66.84	1656
HSA-MIR-6787-3P	97.75	66.17	1233
HSA-MIR-4646-5P	97.70	66.84	1692

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	fam161b	ENSDARG00000089467
mus_musculus	Fam161b	ENSMUSG00000021234
rattus_norvegicus	Fam161b	ENSRNOG00000011112

Paralogs (2): FAM161A (ENSG00000170264), TSGA10IP (ENSG00000175513)

Protein

Protein identifiers

Protein FAM161B — Q96MY7 (reviewed: Q96MY7)

All UniProt accessions (2): Q96MY7, H0YJ62

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Interacts with FAM161A.

Tissue specificity. Ubiquitously expressed.

Similarity. Belongs to the FAM161 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96MY7-1	1	yes
Q96MY7-2	2

RefSeq proteins (1): NP_689658* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019579	FAM161A/B	Family
IPR051655	FAM161	Family

Pfam: PF10595

UniProt features (19 total): region of interest 6, compositionally biased region 4, sequence variant 3, sequence conflict 2, coiled-coil region 2, chain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96MY7-F1	68.34	0.22

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 45 (showing top): chr14q24, GOBP_CILIUM_ORGANIZATION, GOBP_CELL_PROJECTION_ORGANIZATION, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, GOCC_CYTOPLASMIC_MICROTUBULE, STAT6_01, GOCC_SUPRAMOLECULAR_COMPLEX, GOCC_POLYMERIC_CYTOSKELETAL_FIBER, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GOCC_SUPRAMOLECULAR_POLYMER, GSE14415_NATURAL_TREG_VS_FOXP3_KO_NATURAL_TREG_UP, GSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_12H_DN, CBX7_TARGET_GENES, MAFG_TARGET_GENES, ZNF618_TARGET_GENES

GO Biological Process (1): cilium organization (GO:0044782)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): cytoplasmic microtubule (GO:0005881), microtubule cytoskeleton (GO:0015630), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
organelle organization	1
plasma membrane bounded cell projection organization	1
binding	1
cytoplasm	1
microtubule	1
cytoskeleton	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

472 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FAM161B	LRRC74A	Q0VAA2	697
FAM161B	CFAP36	Q96G28	618
FAM161B	ENTPD5	O75356	617
FAM161B	AZGP1	P25311	509
FAM161B	PTGR2	Q8N8N7	507
FAM161B	LIN52	Q52LA3	482
FAM161B	AREL1	O15033	478
FAM161B	FCF1	Q9Y324	453
FAM161B	CMTR2	Q8IYT2	435
FAM161B	VRTN	Q9H8Y1	434
FAM161B	RP1L1	Q8IWN7	391
FAM161B	TMC5	Q6UXY8	367
FAM161B	LZTS1	Q9Y250	361
FAM161B	BIVM	Q86UB2	349
FAM161B	EIF4ENIF1	Q9NRA8	341

IntAct

226 interactions, top by confidence:

A	B	Type	Score
SYCE1	FAM161B	psi-mi:“MI:0915”(physical association)	0.600
USH1G	FAM161B	psi-mi:“MI:0915”(physical association)	0.600
OIP5	FAM161B	psi-mi:“MI:0915”(physical association)	0.600
FAM161B	ZNF212	psi-mi:“MI:0915”(physical association)	0.560
FAM161B	CDR2	psi-mi:“MI:0915”(physical association)	0.560
FAM161B	TTC23	psi-mi:“MI:0915”(physical association)	0.560
FAM161B	ANKRD23	psi-mi:“MI:0915”(physical association)	0.560
FAM161B	ZC4H2	psi-mi:“MI:0915”(physical association)	0.560
FAM161B	TEX12	psi-mi:“MI:0915”(physical association)	0.560
GOLGA2	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
CDR2	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
TRAF2	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
KIAA1328	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
TTC23	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
ANKRD23	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
CCDC125	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
TSNAXIP1	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
FAM161B	MDFI	psi-mi:“MI:0915”(physical association)	0.560
STX11	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
FAM161B	PICK1	psi-mi:“MI:0915”(physical association)	0.560
PNMA1	FAM161B	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (81): KLHL15 (Affinity Capture-MS), ACAD8 (Affinity Capture-MS), FAM161B (PCA), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid), FAM161B (Two-hybrid)

ESM2 similar proteins: A0A1B0GTD5, A0A1B0GUX0, A0A3Q1MT14, A2BFC9, A4II40, A4QMS7, A5A6J4, A6NJV1, A6NL82, A8IB22, A8QW39, B0BM24, B0UXH9, B5X5D0, B9EJX3, F1MMV1, F1P3Y5, M0R3K6, O95990, P83565, Q2KI52, Q32L72, Q32P67, Q3B820, Q3SZR5, Q5BN46, Q5M7D8, Q5M7F8, Q5NC57, Q5NVP3, Q5XIN9, Q66KE9, Q6AY14, Q6AYM0, Q6P3G4, Q6ZN84, Q6ZQR2, Q6ZVS7, Q78TU8, Q8CB59

Diamond homologs: B0BM24, Q3B820, Q66KE9, Q6AY14, Q8CB59, Q8QZV6, Q96MY7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

125 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	109
Likely benign	11
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

984 predictions. Top by Δscore:

Variant	Effect	Δscore
14:73935943:GGTTA:G	donor_loss	1.0000
14:73935944:GTTAC:G	donor_loss	1.0000
14:73935945:TTAC:T	donor_loss	1.0000
14:73935946:TAC:T	donor_loss	1.0000
14:73935947:ACCTG:A	donor_loss	1.0000
14:73935948:C:CA	donor_loss	1.0000
14:73936084:AGATC:A	acceptor_gain	1.0000
14:73936085:GATC:G	acceptor_gain	1.0000
14:73936086:ATC:A	acceptor_gain	1.0000
14:73936087:TC:T	acceptor_gain	1.0000
14:73936088:CC:C	acceptor_gain	1.0000
14:73936089:C:CA	acceptor_loss	1.0000
14:73936089:C:CC	acceptor_gain	1.0000
14:73937978:T:TA	donor_gain	1.0000
14:73938108:CACTT:C	acceptor_gain	1.0000
14:73938110:CTT:C	acceptor_gain	1.0000
14:73938111:TT:T	acceptor_gain	1.0000
14:73938113:C:CC	acceptor_gain	1.0000
14:73940921:CTCA:C	donor_loss	1.0000
14:73940922:TCA:T	donor_loss	1.0000
14:73940923:CA:C	donor_loss	1.0000
14:73940924:A:AC	donor_gain	1.0000
14:73940925:C:CC	donor_gain	1.0000
14:73940925:CCTGA:C	donor_gain	1.0000
14:73941050:AATC:A	acceptor_gain	1.0000
14:73941051:ATC:A	acceptor_gain	1.0000
14:73941052:TC:T	acceptor_gain	1.0000
14:73941053:CC:C	acceptor_gain	1.0000
14:73941054:C:CC	acceptor_gain	1.0000
14:73941055:T:G	acceptor_loss	1.0000

AlphaMissense

4240 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:73944612:G:C	F216L	0.992
14:73944612:G:T	F216L	0.992
14:73944614:A:G	F216L	0.992
14:73944735:G:C	F175L	0.991
14:73944735:G:T	F175L	0.991
14:73944737:A:G	F175L	0.991
14:73937948:C:G	R522P	0.989
14:73937642:C:G	R542P	0.984
14:73944613:A:G	F216S	0.981
14:73937683:T:A	R528S	0.979
14:73937683:T:G	R528S	0.979
14:73942438:G:C	F401L	0.979
14:73942438:G:T	F401L	0.979
14:73942440:A:G	F401L	0.979
14:73944730:A:G	M177T	0.978
14:73944483:G:C	F259L	0.975
14:73944483:G:T	F259L	0.975
14:73944485:A:G	F259L	0.975
14:73944586:A:T	V225D	0.972
14:73944729:C:A	M177I	0.971
14:73944729:C:G	M177I	0.971
14:73944729:C:T	M177I	0.971
14:73938012:C:G	A501P	0.968
14:73944613:A:C	F216C	0.967
14:73940940:C:A	R462S	0.966
14:73940940:C:G	R462S	0.966
14:73937672:T:G	Y532S	0.963
14:73942549:G:C	F364L	0.962
14:73942549:G:T	F364L	0.962
14:73942551:A:G	F364L	0.962

dbSNP variants (sampled 300 via entrez): RS1000165870 (14:73939599 CTCTGCTGGAA>C), RS1000198495 (14:73943314 TC>T), RS1000226933 (14:73945795 G>A), RS1000229538 (14:73947912 G>A), RS1000272177 (14:73942982 C>G), RS1000426250 (14:73949306 T>C), RS1000519844 (14:73937315 C>A), RS1000534251 (14:73941825 C>T), RS1000553321 (14:73943081 C>T), RS1000764308 (14:73943456 A>C), RS1000820479 (14:73930638 C>T), RS1000827359 (14:73947411 G>A), RS1000841175 (14:73941761 G>A), RS1000929463 (14:73937673 A>G), RS1000932910 (14:73930311 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005557_1	Serum uric acid levels	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004761	uric acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
manganese chloride	decreases expression, increases abundance	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Arsenic	affects methylation	1
Vehicle Emissions	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Coumestrol	decreases expression, affects cotreatment	1
Estradiol	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Manganese	decreases expression, increases abundance	1
Methapyrilene	increases methylation	1
Methyl Methanesulfonate	increases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Urethane	increases expression	1
Aflatoxin B1	increases methylation	1
Particulate Matter	increases abundance, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.