FAM174C

Summary

FAM174C (family with sequence similarity 174 member C, HGNC:26073) is a protein-coding gene on chromosome 19p13.3, encoding Protein FAM174C (Q9BVV8).

Located in cytoplasm and extracellular region.

Source: NCBI Gene 55009 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 3 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26073
Approved symbol	FAM174C
Name	family with sequence similarity 174 member C
Location	19p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20640
Ensembl gene	ENSG00000228300
Ensembl biotype	protein_coding
Entrez	55009

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000469144

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000469144 — 3 exons

Exon	Start	End
ENSE00001906655	1276021	1276103
ENSE00004473924	1277183	1277299
ENSE00004474395	1278777	1279244

Expression profiles

Bgee: expression breadth ubiquitous, 238 present calls, max score 96.39.

Top tissues by expression

273 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	96.39	gold quality
right lobe of liver	UBERON:0001114	96.37	gold quality
right adrenal gland	UBERON:0001233	95.65	gold quality
lower esophagus mucosa	UBERON:0035834	95.29	gold quality
right adrenal gland cortex	UBERON:0035827	95.15	gold quality
left adrenal gland	UBERON:0001234	95.13	gold quality
left adrenal gland cortex	UBERON:0035825	94.97	gold quality
apex of heart	UBERON:0002098	94.94	gold quality
granulocyte	CL:0000094	94.11	gold quality
adrenal cortex	UBERON:0001235	93.74	gold quality
adenohypophysis	UBERON:0002196	93.71	gold quality
right lobe of thyroid gland	UBERON:0001119	93.50	gold quality
body of pancreas	UBERON:0001150	93.05	gold quality
body of stomach	UBERON:0001161	92.93	gold quality
right testis	UBERON:0004534	92.74	gold quality
left lobe of thyroid gland	UBERON:0001120	92.70	gold quality
left testis	UBERON:0004533	92.64	gold quality
adrenal gland	UBERON:0002369	92.41	gold quality
metanephros cortex	UBERON:0010533	92.33	gold quality
skin of abdomen	UBERON:0001416	92.26	gold quality
stromal cell of endometrium	CL:0002255	92.20	gold quality
skin of leg	UBERON:0001511	92.10	gold quality
left coronary artery	UBERON:0001626	91.91	gold quality
spleen	UBERON:0002106	91.88	gold quality
minor salivary gland	UBERON:0001830	91.83	gold quality
esophagus mucosa	UBERON:0002469	91.78	gold quality
omental fat pad	UBERON:0010414	91.77	gold quality
peritoneum	UBERON:0002358	91.72	gold quality
pituitary gland	UBERON:0000007	91.71	gold quality
transverse colon	UBERON:0001157	91.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.27

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting FAM174C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-6762-3P	99.66	66.94	1188
HSA-MIR-12122	99.56	69.33	1672
HSA-MIR-6722-3P	99.45	67.62	1919
HSA-MIR-6734-3P	99.15	66.27	1627
HSA-MIR-1909-3P	99.03	66.56	1662
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-647	97.73	67.79	927
HSA-MIR-4486	96.96	60.61	931

Literature-anchored findings (GeneRIF, showing 1)

• The isolation and characterization of a novel human non-classical secreted protein which is encoded by the hypothetical gene C19orf24 (chromosome 19 open reading frame 24), is reported. (PMID:16847563)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Protein FAM174C — Q9BVV8 (reviewed: Q9BVV8)

All UniProt accessions (1): D6W5Y7

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the FAM174 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009565	FAM174-like	Family

Pfam: PF06679

UniProt features (10 total): modified residue 3, region of interest 2, signal peptide 1, chain 1, transmembrane region 1, compositionally biased region 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BVV8-F1	64.02	0.09

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 113, 117, 120

Glycosylation sites (1): 47

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 65 (showing top): DOUGLAS_BMI1_TARGETS_UP, chr19p13, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, NAKAMURA_ADIPOGENESIS_EARLY_UP, NAKAMURA_ADIPOGENESIS_LATE_UP, BANP_TARGET_GENES, DLX6_TARGET_GENES, FEV_TARGET_GENES, FOXD2_TARGET_GENES, FOXN3_TARGET_GENES, NAB2_TARGET_GENES, RBM34_TARGET_GENES, SETD7_TARGET_GENES, ZBTB12_TARGET_GENES, ZNF184_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (3): extracellular region (GO:0005576), cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
intracellular anatomical structure	1

Protein interactions and networks

STRING

418 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FAM174C	RBIS	Q8N0T1	576
FAM174C	CBARP	Q8N350	544
FAM174C	TMEM259	Q4ZIN3	537
FAM174C	SBNO2	Q9Y2G9	511
FAM174C	CCDC160	A6NGH7	495
FAM174C	CIRBP	Q14011	484
FAM174C	LRRCC1	Q9C099	482
FAM174C	ARHGAP45	Q92619	482
FAM174C	C19orf25	Q9UFG5	477
FAM174C	R3HDM4	Q96D70	476
FAM174C	WDR18	Q9BV38	459
FAM174C	SLC25A53	Q5H9E4	449
FAM174C	DAZAP1	Q96EP5	441
FAM174C	CFAP73	A6NFT4	419
FAM174C	POLR2E	P19388	415

IntAct

3 interactions, top by confidence:

A	B	Type	Score
FAM174C	MAP2K7	psi-mi:“MI:0914”(association)	0.350
FAM174C	fliM	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (5): MAP2K7 (Affinity Capture-MS), NSF (Affinity Capture-MS), RAB11FIP2 (Affinity Capture-MS), SLC41A1 (Affinity Capture-MS), VAMP3 (Affinity Capture-MS)

ESM2 similar proteins: A0A5F4BST2, A5PJC7, A8MWV9, D3ZZP4, O14836, P0CAN6, P11911, P11912, P14753, Q01114, Q07303, Q13113, Q2KI80, Q2KL21, Q3TS39, Q3URD2, Q4V9L6, Q5F267, Q5FVJ4, Q5FVQ7, Q5RA41, Q5T1S8, Q6P9G4, Q6UWJ8, Q6UX34, Q80VJ8, Q810F0, Q86XR5, Q8BRJ3, Q8BX43, Q8K064, Q8K5A9, Q8N112, Q8N4K4, Q8N6L0, Q8NBR0, Q8NC24, Q8QZT4, Q8R138, Q923S2

Diamond homologs: Q9BVV8, Q9DAZ5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

501 predictions. Top by Δscore:

Variant	Effect	Δscore
19:1275823:GCGTT:G	donor_gain	1.0000
19:1275827:TTAGG:T	donor_loss	1.0000
19:1275829:AGG:A	donor_loss	1.0000
19:1275831:GT:G	donor_loss	1.0000
19:1275832:T:A	donor_loss	1.0000
19:1277176:C:G	acceptor_gain	1.0000
19:1277178:TCCA:T	acceptor_loss	1.0000
19:1277179:CCA:C	acceptor_loss	1.0000
19:1277180:CAGG:C	acceptor_loss	1.0000
19:1277181:A:AG	acceptor_gain	1.0000
19:1277182:G:A	acceptor_loss	1.0000
19:1277182:G:GG	acceptor_gain	1.0000
19:1277296:GATG:G	donor_gain	1.0000
19:1277175:A:AG	acceptor_gain	0.9900
19:1277181:AG:A	acceptor_gain	0.9900
19:1277181:AGGTT:A	acceptor_gain	0.9900
19:1277182:GG:G	acceptor_gain	0.9900
19:1277182:GGT:G	acceptor_gain	0.9900
19:1277182:GGTT:G	acceptor_gain	0.9900
19:1277182:GGTTG:G	acceptor_gain	0.9900
19:1277288:G:GT	donor_gain	0.9900
19:1275822:G:GT	donor_gain	0.9800
19:1277179:CCAGG:C	acceptor_gain	0.9800
19:1277278:T:TG	donor_gain	0.9800
19:1277296:GATGG:G	donor_loss	0.9800
19:1277300:G:GG	donor_gain	0.9800
19:1276370:GCT:G	donor_gain	0.9700
19:1277180:CAGGT:C	acceptor_gain	0.9700
19:1277181:AGG:A	acceptor_gain	0.9700
19:1277297:A:G	donor_gain	0.9700

AlphaMissense

833 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000091381 (19:1277843 C>G,T), RS1000099801 (19:1275515 TA>T), RS1000401424 (19:1275592 C>G,T), RS1000465668 (19:1279332 G>T), RS1000754597 (19:1279525 C>T), RS1001539687 (19:1277183 G>A,T), RS1001649380 (19:1274980 A>C), RS1001765224 (19:1275107 T>C), RS1001810716 (19:1276024 C>A,G,T), RS1001921135 (19:1277836 A>G), RS1001986180 (19:1274273 G>A), RS1002094510 (19:1276174 T>A), RS1002143295 (19:1278840 C>G,T), RS1002151238 (19:1274458 G>A), RS1002377493 (19:1277028 G>A,C,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	3
FR900359	decreases phosphorylation	1
bisphenol A	increases methylation	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
perfluorooctane sulfonic acid	increases expression	1
K 7174	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Acetaminophen	decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	increases expression	1
Cannabidiol	increases expression	1
Manganese	increases expression, affects cotreatment, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	increases methylation	1
Vitamin E	decreases expression	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	decreases expression	1
Okadaic Acid	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2WW	Abcam HEK293T FAM174C KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.