FAM181A-AS1

Summary

FAM181A-AS1 (FAM181A antisense RNA 1, HGNC:20133) is a long non-coding RNA gene on chromosome 14q32.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20133
Approved symbol	FAM181A-AS1
Name	FAM181A antisense RNA 1
Location	14q32.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258584
Ensembl biotype	lncRNA
Entrez	283592
RNAcentral	URS0000CCDFA7 — lncRNA, 2441 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000554538, ENST00000554742, ENST00000555732, ENST00000556290, ENST00000797336, ENST00000807325

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000554538 — 3 exons

Exon	Start	End
ENSE00002440703	93923673	93924000
ENSE00002450868	93926915	93926966
ENSE00002453910	93925112	93925276

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 78.45.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0650 / max 9.9239, expressed in 38 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
144647	0.0544	34
144646	0.0105	4

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	78.45	gold quality
testis	UBERON:0000473	77.77	gold quality
gastrocnemius	UBERON:0001388	77.48	gold quality
muscle of leg	UBERON:0001383	76.82	gold quality
bone marrow cell	CL:0002092	76.29	silver quality
right testis	UBERON:0004534	76.24	gold quality
ventricular zone	UBERON:0003053	75.30	gold quality
skeletal muscle tissue	UBERON:0001134	75.11	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.58	gold quality
ganglionic eminence	UBERON:0004023	71.73	gold quality
right uterine tube	UBERON:0001302	69.43	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.54	gold quality
prefrontal cortex	UBERON:0000451	63.52	gold quality
liver	UBERON:0002107	63.47	silver quality
temporal lobe	UBERON:0001871	63.27	gold quality
amygdala	UBERON:0001876	63.17	gold quality
nucleus accumbens	UBERON:0001882	62.58	gold quality
anterior cingulate cortex	UBERON:0009835	62.48	gold quality
caudate nucleus	UBERON:0001873	62.46	gold quality
right lung	UBERON:0002167	61.87	gold quality
frontal cortex	UBERON:0001870	61.72	gold quality
cerebral cortex	UBERON:0000956	61.31	gold quality
fallopian tube	UBERON:0003889	60.88	gold quality
superior frontal gyrus	UBERON:0002661	60.85	gold quality
Ammon’s horn	UBERON:0001954	60.66	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	60.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.03	gold quality
cortical plate	UBERON:0005343	60.02	silver quality
bone marrow	UBERON:0002371	59.93	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2. (PMID:33080570)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.