FAM201A

Summary

FAM201A (family with sequence similarity 201 member A, HGNC:27239) is a long non-coding RNA gene on chromosome 9p13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27239
Approved symbol	FAM201A
Name	family with sequence similarity 201 member A
Location	9p13.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000204860
Ensembl biotype	lncRNA
Entrez	158228
RNAcentral	URS000075AC74 — lncRNA, 1741 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000377680, ENST00000471864, ENST00000484285, ENST00000665533, ENST00000667135

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000377680 — 2 exons

Exon	Start	End
ENSE00001474836	38621832	38624990
ENSE00001474837	38621088	38621365

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 80.16.

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	80.16	gold quality
bone marrow cell	CL:0002092	77.25	gold quality
spinal cord	UBERON:0002240	76.71	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.51	gold quality
endothelial cell	CL:0000115	74.42	gold quality
nucleus accumbens	UBERON:0001882	74.12	gold quality
body of pancreas	UBERON:0001150	73.39	gold quality
caudate nucleus	UBERON:0001873	72.24	gold quality
sural nerve	UBERON:0015488	71.10	gold quality
putamen	UBERON:0001874	70.43	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.35	gold quality
right uterine tube	UBERON:0001302	69.86	gold quality
pancreas	UBERON:0001264	69.64	gold quality
oviduct epithelium	UBERON:0004804	69.50	gold quality
hypothalamus	UBERON:0001898	69.48	gold quality
prefrontal cortex	UBERON:0000451	69.17	gold quality
anterior cingulate cortex	UBERON:0009835	69.06	gold quality
bronchial epithelial cell	CL:0002328	68.25	gold quality
substantia nigra	UBERON:0002038	68.10	gold quality
mucosa of transverse colon	UBERON:0004991	67.92	gold quality
bronchus	UBERON:0002185	66.99	gold quality
metanephros cortex	UBERON:0010533	66.93	gold quality
left lobe of thyroid gland	UBERON:0001120	66.34	gold quality
endocervix	UBERON:0000458	66.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	66.15	gold quality
right lobe of thyroid gland	UBERON:0001119	66.08	gold quality
palpebral conjunctiva	UBERON:0001812	65.74	gold quality
thyroid gland	UBERON:0002046	65.74	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.47	gold quality
midbrain	UBERON:0001891	64.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Up-regulation of FGF2 and down-regulation FAM201A were correlated with the development of osteonecrosis of the femoral head after femoral neck fracture. (PMID:29382571)
• Long noncoding RNA FAM201A involves in radioresistance of non-small-cell lung cancer by enhancing EGFR expression via miR-370. (PMID:31298332)
• TCF3-activated FAM201A enhances cell proliferation and invasion via miR-186-5p/TNKS1BP1 axis in triple-negative breast cancer. (PMID:33011533)
• FAM201A knockdown inhibits proliferation and invasion of lung adenocarcinoma cells by regulating miR-7515/GLO1 axis. (PMID:33687075)
• Long non-coding RNA FAM201A promotes lung squamous cell carcinoma progression through interaction with miR-101. (PMID:34227092)
• Positive feedback loop of lncRNA FAM201A/miR146a5p/POU2F1 regulates IL1betainduced chondrocyte injury in vitro. (PMID:34796909)
• FAM201A, a long noncoding RNA potentially associated with atrial fibrillation identified by ceRNA network analyses and WGCNA. (PMID:35410298)
• FAM201A encodes small protein NBASP to inhibit neuroblastoma progression via inactivating MAPK pathway mediated by FABP5. (PMID:37438449)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.