FAM215A

Summary

FAM215A (family with sequence similarity 215 member A, HGNC:17505) is a long non-coding RNA gene on chromosome 17q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17505
Approved symbol	FAM215A
Name	family with sequence similarity 215 member A
Location	17q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	APR-2, LINC00530
Ensembl gene	ENSG00000267496
Ensembl biotype	lncRNA
Entrez	23591
RNAcentral	URS000075B909 — lncRNA, 780 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000588043, ENST00000632077

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000588043 — 1 exons

Exon	Start	End
ENSE00002890705	43917209	43917963

Expression profiles

Bgee: expression breadth ubiquitous, 148 present calls, max score 86.64.

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.64	gold quality
buccal mucosa cell	CL:0002336	74.93	gold quality
ganglionic eminence	UBERON:0004023	62.82	gold quality
granulocyte	CL:0000094	61.71	gold quality
right coronary artery	UBERON:0001625	61.32	gold quality
cortical plate	UBERON:0005343	61.29	gold quality
leukocyte	CL:0000738	60.27	gold quality
right lobe of liver	UBERON:0001114	59.75	gold quality
monocyte	CL:0000576	59.66	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	58.69	gold quality
transverse colon	UBERON:0001157	58.11	gold quality
right uterine tube	UBERON:0001302	58.11	gold quality
left lobe of thyroid gland	UBERON:0001120	57.37	gold quality
gall bladder	UBERON:0002110	57.29	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.25	gold quality
lymph node	UBERON:0000029	56.96	gold quality
left ovary	UBERON:0002119	56.89	gold quality
lower esophagus	UBERON:0013473	56.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	56.85	gold quality
small intestine Peyer’s patch	UBERON:0003454	56.84	gold quality
right ovary	UBERON:0002118	56.78	gold quality
spleen	UBERON:0002106	56.77	gold quality
ectocervix	UBERON:0012249	56.61	gold quality
prefrontal cortex	UBERON:0000451	56.57	gold quality
esophagus	UBERON:0001043	56.55	gold quality
right lobe of thyroid gland	UBERON:0001119	56.53	gold quality
esophagus mucosa	UBERON:0002469	56.47	gold quality
stromal cell of endometrium	CL:0002255	56.32	gold quality
metanephros cortex	UBERON:0010533	56.18	gold quality
body of stomach	UBERON:0001161	56.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer. (PMID:32295144)
• Up-regulation of BOK-AS1, FAM215A and FEZF1-AS1 lncRNAs and their potency as moderate diagnostic biomarkers in gastric cancer. (PMID:37364417)
• Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines. (PMID:38165572)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.