FAM222A-AS1

Summary

FAM222A-AS1 (FAM222A antisense RNA 1, HGNC:28223) is a long non-coding RNA gene on chromosome 12q24.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28223
Approved symbol	FAM222A-AS1
Name	FAM222A antisense RNA 1
Location	12q24.11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255650
Ensembl biotype	lncRNA
Entrez	84983
RNAcentral	URS000075B21F — lncRNA, 868 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000536474, ENST00000541460, ENST00000541723

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000536474 — 2 exons

Exon	Start	End
ENSE00002257768	109734412	109734593
ENSE00002277323	109735591	109735957

Expression profiles

Bgee: expression breadth ubiquitous, 149 present calls, max score 89.61.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0956 / max 14.3536, expressed in 51 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133197	0.0680	31
133198	0.0277	11

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.61	gold quality
buccal mucosa cell	CL:0002336	78.69	silver quality
right testis	UBERON:0004534	78.28	gold quality
left testis	UBERON:0004533	77.59	gold quality
testis	UBERON:0000473	74.72	gold quality
colonic epithelium	UBERON:0000397	73.62	gold quality
sperm	CL:0000019	72.99	gold quality
islet of Langerhans	UBERON:0000006	71.23	gold quality
left adrenal gland cortex	UBERON:0035825	71.18	gold quality
left adrenal gland	UBERON:0001234	70.93	gold quality
right adrenal gland	UBERON:0001233	70.87	gold quality
right adrenal gland cortex	UBERON:0035827	70.55	gold quality
adrenal tissue	UBERON:0018303	69.75	gold quality
adrenal gland	UBERON:0002369	69.26	gold quality
adrenal cortex	UBERON:0001235	68.91	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.34	gold quality
muscle of leg	UBERON:0001383	66.67	gold quality
gastrocnemius	UBERON:0001388	65.42	gold quality
ventricular zone	UBERON:0003053	62.49	gold quality
ganglionic eminence	UBERON:0004023	62.24	gold quality
hypothalamus	UBERON:0001898	62.05	gold quality
prefrontal cortex	UBERON:0000451	60.54	gold quality
sural nerve	UBERON:0015488	59.01	silver quality
pancreas	UBERON:0001264	58.90	gold quality
left ovary	UBERON:0002119	58.89	gold quality
right lobe of liver	UBERON:0001114	58.37	gold quality
right ovary	UBERON:0002118	58.33	gold quality
gall bladder	UBERON:0002110	58.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	58.07	gold quality
substantia nigra	UBERON:0002038	57.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.71

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.