FAM223B

Summary

FAM223B (family with sequence similarity 223 member B, HGNC:34048) is a long non-coding RNA gene on chromosome Xq28.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34048
Approved symbol	FAM223B
Name	family with sequence similarity 223 member B
Location	Xq28
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000272681
Ensembl biotype	lncRNA
Entrez	286967
RNAcentral	URS000075CB6D — lncRNA, 713 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000598177

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000598177 — 1 exons

Exon	Start	End
ENSE00003171146	154632470	154633182

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 73.23.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	73.23	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	71.81	gold quality
sural nerve	UBERON:0015488	69.64	silver quality
bone marrow	UBERON:0002371	69.56	gold quality
right lobe of liver	UBERON:0001114	69.22	gold quality
liver	UBERON:0002107	69.15	gold quality
blood	UBERON:0000178	68.25	gold quality
apex of heart	UBERON:0002098	66.54	gold quality
stromal cell of endometrium	CL:0002255	65.79	gold quality
monocyte	CL:0000576	65.57	gold quality
colonic epithelium	UBERON:0000397	65.12	silver quality
leukocyte	CL:0000738	64.81	gold quality
popliteal artery	UBERON:0002250	63.64	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.61	gold quality
tibial artery	UBERON:0007610	63.57	gold quality
left coronary artery	UBERON:0001626	62.86	gold quality
left lobe of thyroid gland	UBERON:0001120	62.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	62.47	gold quality
body of uterus	UBERON:0009853	62.39	gold quality
lymph node	UBERON:0000029	62.15	gold quality
tonsil	UBERON:0002372	61.94	gold quality
thyroid gland	UBERON:0002046	61.70	gold quality
body of pancreas	UBERON:0001150	61.53	gold quality
skin of abdomen	UBERON:0001416	61.44	gold quality
skeletal muscle tissue	UBERON:0001134	60.66	gold quality
granulocyte	CL:0000094	60.48	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.37	gold quality
spleen	UBERON:0002106	60.28	gold quality
small intestine	UBERON:0002108	60.26	gold quality
zone of skin	UBERON:0000014	59.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): FAM223A (ENSG00000279245)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.