FAM224A

Summary

FAM224A (family with sequence similarity 224 member A, HGNC:37736) is a long non-coding RNA gene on chromosome Yq11.222.

This locus is transcribed but does not appear to encode a protein. Two identical copies of this gene are present in a palindromic region on chromosome Y. This record represents the more telomeric copy.

Source: NCBI Gene 401630 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37736
Approved symbol	FAM224A
Name	family with sequence similarity 224 member A
Location	Yq11.222
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233522
Ensembl biotype	lncRNA
Entrez	401630
RNAcentral	URS0000759CFB — lncRNA, 463 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000419557, ENST00000776196, ENST00000776197, ENST00000776198, ENST00000776199, ENST00000776200, ENST00000776201, ENST00000776202, ENST00000776203, ENST00000776204, ENST00000776205, ENST00000776206, ENST00000776207, ENST00000776208, ENST00000776209, ENST00000776210, ENST00000776211, ENST00000776212, ENST00000776213, ENST00000776214, ENST00000776215, ENST00000776216

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419557 — 5 exons

Exon	Start	End
ENSE00001640636	18329191	18329308
ENSE00001672475	18326253	18326690
ENSE00001710040	18351884	18351968
ENSE00001758131	18350000	18350234
ENSE00001790139	18352056	18353210

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 61.81.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
testis	UBERON:0000473	61.81	gold quality
cortical plate	UBERON:0005343	60.38	silver quality
placenta	UBERON:0001987	59.71	gold quality
liver	UBERON:0002107	58.72	gold quality
left adrenal gland cortex	UBERON:0035825	55.38	gold quality
vermiform appendix	UBERON:0001154	53.43	gold quality
left testis	UBERON:0004533	52.98	gold quality
blood	UBERON:0000178	52.32	gold quality
cortex of kidney	UBERON:0001225	51.98	gold quality
Brodmann (1909) area 9	UBERON:0013540	51.77	gold quality
right lobe of liver	UBERON:0001114	50.84	gold quality
pancreas	UBERON:0001264	50.78	gold quality
islet of Langerhans	UBERON:0000006	50.67	gold quality
prefrontal cortex	UBERON:0000451	50.60	gold quality
adult mammalian kidney	UBERON:0000082	50.47	gold quality
superior frontal gyrus	UBERON:0002661	50.22	gold quality
body of pancreas	UBERON:0001150	49.87	gold quality
frontal cortex	UBERON:0001870	49.78	gold quality
gall bladder	UBERON:0002110	49.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	49.21	gold quality
cerebral cortex	UBERON:0000956	49.12	gold quality
ascending aorta	UBERON:0001496	49.03	gold quality
prostate gland	UBERON:0002367	48.71	gold quality
tonsil	UBERON:0002372	48.54	gold quality
thoracic aorta	UBERON:0001515	48.08	gold quality
right adrenal gland	UBERON:0001233	47.87	gold quality
esophagus mucosa	UBERON:0002469	47.86	gold quality
Ammon’s horn	UBERON:0001954	47.82	gold quality
lymph node	UBERON:0000029	47.46	gold quality
heart left ventricle	UBERON:0002084	47.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• this study revealed that A1CF can upregulate the expression of FAM224A via strengthening its stability, which in turn, influenced the negative modulation of miR-590-3p on transcription factor ZNF143. (PMID:31186064)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.