FAM224B

Summary

FAM224B (family with sequence similarity 224 member B, HGNC:37737) is a long non-coding RNA gene on chromosome Yq11.222.

This locus is transcribed but does not appear to encode a protein. Two identical copies of this gene are present in a palindromic region on chromosome Y. This record represents the more centromeric copy.

Source: NCBI Gene 401629 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37737
Approved symbol	FAM224B
Name	family with sequence similarity 224 member B
Location	Yq11.222
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230663
Ensembl biotype	lncRNA
Entrez	401629
RNAcentral	URS000075F000 — lncRNA, 462 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 32 lncRNA

ENST00000458667, ENST00000729283, ENST00000729284, ENST00000729285, ENST00000729286, ENST00000729287, ENST00000729288, ENST00000729289, ENST00000729290, ENST00000729291, ENST00000729292, ENST00000729293, ENST00000729294, ENST00000729295, ENST00000729296, ENST00000729297, ENST00000729298, ENST00000729299, ENST00000729300, ENST00000729301, ENST00000729302, ENST00000729303, ENST00000729304, ENST00000729305, ENST00000729306, ENST00000729307, ENST00000729308, ENST00000729309, ENST00000729310, ENST00000729311, ENST00000729312, ENST00000729313

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000458667 — 5 exons

Exon	Start	End
ENSE00001606680	17552800	17553954
ENSE00001734255	17576703	17576820
ENSE00001738421	17554042	17554126
ENSE00001743559	17579316	17579754
ENSE00001754684	17555776	17556010

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 67.16.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	67.16	gold quality
right testis	UBERON:0004534	66.57	gold quality
left testis	UBERON:0004533	65.46	gold quality
liver	UBERON:0002107	65.11	gold quality
testis	UBERON:0000473	65.06	gold quality
adult mammalian kidney	UBERON:0000082	64.26	gold quality
kidney	UBERON:0002113	61.55	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.12	gold quality
left lobe of thyroid gland	UBERON:0001120	59.91	gold quality
cortical plate	UBERON:0005343	59.76	silver quality
thyroid gland	UBERON:0002046	58.53	gold quality
right adrenal gland cortex	UBERON:0035827	57.82	gold quality
right frontal lobe	UBERON:0002810	57.65	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	57.44	gold quality
Brodmann (1909) area 9	UBERON:0013540	56.89	gold quality
skin of abdomen	UBERON:0001416	56.72	gold quality
right lobe of thyroid gland	UBERON:0001119	56.53	gold quality
upper lobe of left lung	UBERON:0008952	56.43	gold quality
esophagus mucosa	UBERON:0002469	55.67	gold quality
prostate gland	UBERON:0002367	55.49	gold quality
zone of skin	UBERON:0000014	55.47	gold quality
lung	UBERON:0002048	55.32	gold quality
cerebral cortex	UBERON:0000956	54.92	gold quality
left adrenal gland cortex	UBERON:0035825	54.89	gold quality
Ammon’s horn	UBERON:0001954	54.85	gold quality
placenta	UBERON:0001987	54.73	gold quality
skin of leg	UBERON:0001511	54.48	gold quality
heart left ventricle	UBERON:0002084	54.46	gold quality
frontal cortex	UBERON:0001870	54.02	gold quality
cortex of kidney	UBERON:0001225	53.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.40

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.