FAM225A

Summary

FAM225A (family with sequence similarity 225 member A, HGNC:27855) is a long non-coding RNA gene on chromosome 9q32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27855
Approved symbol	FAM225A
Name	family with sequence similarity 225 member A
Location	9q32
Locus type	RNA, long non-coding
Status	Approved
Aliases	DKFZp686A0127
Ensembl gene	ENSG00000231528
Ensembl biotype	lncRNA
Entrez	286333
RNAcentral	URS000075BD7B — lncRNA, 5802 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000434051, ENST00000453010, ENST00000846846, ENST00000846847, ENST00000846848, ENST00000846849, ENST00000846850, ENST00000846851, ENST00000846852

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434051 — 2 exons

Exon	Start	End
ENSE00004275063	113113059	113113663
ENSE00004275071	113114420	113119928

Expression profiles

Bgee: expression breadth ubiquitous, 146 present calls, max score 87.35.

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	87.35	gold quality
right testis	UBERON:0004534	87.10	gold quality
testis	UBERON:0000473	84.87	gold quality
adult organism	UBERON:0007023	83.56	gold quality
sperm	CL:0000019	82.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	76.98	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.64	gold quality
pancreatic ductal cell	CL:0002079	75.89	silver quality
spinal cord	UBERON:0002240	75.19	gold quality
stromal cell of endometrium	CL:0002255	73.73	gold quality
monocyte	CL:0000576	71.60	gold quality
leukocyte	CL:0000738	70.91	gold quality
myocardium	UBERON:0002349	69.60	gold quality
cardiac muscle of right atrium	UBERON:0003379	67.74	gold quality
upper arm skin	UBERON:0004263	67.67	gold quality
left ventricle myocardium	UBERON:0006566	67.38	gold quality
smooth muscle tissue	UBERON:0001135	66.04	gold quality
granulocyte	CL:0000094	65.94	gold quality
substantia nigra	UBERON:0002038	65.19	gold quality
tibia	UBERON:0000979	64.55	silver quality
midbrain	UBERON:0001891	64.20	gold quality
body of uterus	UBERON:0009853	63.92	gold quality
amygdala	UBERON:0001876	63.11	gold quality
putamen	UBERON:0001874	63.01	gold quality
deltoid	UBERON:0001476	62.25	gold quality
endothelial cell	CL:0000115	61.44	gold quality
vermiform appendix	UBERON:0001154	61.15	gold quality
parotid gland	UBERON:0001831	61.08	gold quality
Ammon’s horn	UBERON:0001954	60.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• High FAM225A expression is associated with Nasopharyngeal Carcinoma Tumorigenesis and Metastasis. (PMID:31331909)
• FAM225A facilitates colorectal cancer progression by sponging miR-613 to regulate NOTCH3. (PMID:32343052)
• Exosomal lncRNA FAM225A accelerates esophageal squamous cell carcinoma progression and angiogenesis via sponging miR-206 to upregulate NETO2 and FOXP1 expression. (PMID:33006432)
• LncRNA FAM225A activates the cGAS-STING signaling pathway by combining FUS to promote CENP-N expression and regulates the progression of nasopharyngeal carcinoma. (PMID:35809496)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.