FAM225B

Summary

FAM225B (family with sequence similarity 225 member B, HGNC:21865) is a long non-coding RNA gene on chromosome 9q32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21865
Approved symbol	FAM225B
Name	family with sequence similarity 225 member B
Location	9q32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225684
Ensembl biotype	lncRNA
Entrez	100128385
RNAcentral	URS000075B874 — lncRNA, 5836 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000423546, ENST00000439875, ENST00000659571, ENST00000660977, ENST00000668459, ENST00000728588, ENST00000728589, ENST00000728590

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423546 — 3 exons

Exon	Start	End
ENSE00001749373	113110910	113111016
ENSE00004055225	113104723	113110153
ENSE00004055228	113111410	113111509

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 81.71.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	81.71	gold quality
testis	UBERON:0000473	81.40	gold quality
right testis	UBERON:0004534	81.37	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.61	gold quality
quadriceps femoris	UBERON:0001377	75.61	gold quality
cerebellar vermis	UBERON:0004720	73.34	gold quality
thymus	UBERON:0002370	69.68	silver quality
colonic epithelium	UBERON:0000397	67.83	silver quality
sural nerve	UBERON:0015488	66.46	silver quality
body of uterus	UBERON:0009853	64.85	gold quality
calcaneal tendon	UBERON:0003701	63.76	gold quality
myometrium	UBERON:0001296	63.33	gold quality
endometrium	UBERON:0001295	61.67	gold quality
tonsil	UBERON:0002372	61.23	gold quality
skeletal muscle tissue	UBERON:0001134	60.23	gold quality
smooth muscle tissue	UBERON:0001135	59.98	gold quality
stromal cell of endometrium	CL:0002255	58.51	gold quality
cortex of kidney	UBERON:0001225	58.39	gold quality
liver	UBERON:0002107	57.74	gold quality
bone marrow	UBERON:0002371	55.66	silver quality
popliteal artery	UBERON:0002250	55.58	gold quality
tibial artery	UBERON:0007610	55.52	gold quality
ectocervix	UBERON:0012249	55.49	gold quality
monocyte	CL:0000576	55.25	gold quality
uterine cervix	UBERON:0000002	55.01	gold quality
lymph node	UBERON:0000029	54.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	54.40	gold quality
descending thoracic aorta	UBERON:0002345	53.96	gold quality
adipose tissue	UBERON:0001013	53.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• FAM225B Is a Prognostic lncRNA for Patients with Recurrent Glioblastoma. (PMID:33299501)
• Knockdown of FAM225B inhibits the progression of the hypertrophic scar following glaucoma surgery by inhibiting autophagy. (PMID:33495826)
• Long noncoding RNA FAM225B facilitates proliferation and metastasis of nasopharyngeal carcinoma cells by regulating miR-613/CCND2 axis. (PMID:34255617)
• LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell Invasion and Migration via Modulating Transcription Factor DDX17. (PMID:37720188)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.