FAM230B

Summary

FAM230B (family with sequence similarity 230 member B, HGNC:32943) is a long non-coding RNA gene on chromosome 22q11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32943
Approved symbol	FAM230B
Name	family with sequence similarity 230 member B
Location	22q11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ46366
Ensembl gene	ENSG00000215498
Ensembl biotype	lncRNA
Entrez	642633
RNAcentral	URS00008C3EB9 — lncRNA, 3566 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 12 lncRNA, 3 retained_intron

ENST00000415376, ENST00000415704, ENST00000420583, ENST00000421576, ENST00000424410, ENST00000430463, ENST00000446717, ENST00000451257, ENST00000726925, ENST00000750766, ENST00000750767, ENST00000750768, ENST00000750769, ENST00000750770, ENST00000750771

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415376 — 9 exons

Exon	Start	End
ENSE00001660976	21173444	21173530
ENSE00001662983	21181023	21181056
ENSE00001671021	21167829	21167969
ENSE00001672583	21180496	21180557
ENSE00001718401	21170473	21170497
ENSE00001747411	21186121	21187077
ENSE00001755097	21191722	21192149
ENSE00001792082	21178431	21178496
ENSE00004472420	21169946	21170004

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 92.51.

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.51	gold quality
right testis	UBERON:0004534	90.90	gold quality
left testis	UBERON:0004533	90.14	gold quality
testis	UBERON:0000473	89.72	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.95	gold quality
ventricular zone	UBERON:0003053	70.07	gold quality
skeletal muscle tissue	UBERON:0001134	66.86	gold quality
sural nerve	UBERON:0015488	65.78	gold quality
liver	UBERON:0002107	61.45	gold quality
monocyte	CL:0000576	58.72	gold quality
corpus callosum	UBERON:0002336	58.44	gold quality
endometrium	UBERON:0001295	57.07	silver quality
islet of Langerhans	UBERON:0000006	56.61	gold quality
ganglionic eminence	UBERON:0004023	56.40	silver quality
blood	UBERON:0000178	56.18	gold quality
multicellular organism	UBERON:0000468	55.71	gold quality
pancreas	UBERON:0001264	54.39	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.38	gold quality
stomach	UBERON:0000945	53.40	gold quality
prefrontal cortex	UBERON:0000451	53.12	gold quality
body of stomach	UBERON:0001161	53.01	gold quality
lymph node	UBERON:0000029	52.92	silver quality
left coronary artery	UBERON:0001626	52.01	gold quality
adrenal tissue	UBERON:0018303	51.85	gold quality
cerebellum	UBERON:0002037	51.46	gold quality
cerebellar cortex	UBERON:0002129	51.42	gold quality
cerebellar hemisphere	UBERON:0002245	51.33	gold quality
tibial nerve	UBERON:0001323	51.25	gold quality
superior frontal gyrus	UBERON:0002661	51.19	gold quality
right adrenal gland cortex	UBERON:0035827	51.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Long non-coding RNA FAM230B is a novel prognostic and diagnostic biomarker for lung adenocarcinoma. (PMID:35287554)
• The Subcellular Localization of IncRNA FAM230B in Osteosarcoma and Its Interaction with Early miR-203. (PMID:35377981)
• Analysis of the subcellular location of FAM230B and its interaction with premature miR-302b in osteosarcoma. (PMID:35639175)
• METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer. (PMID:39278369)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.