FAM234A

Summary

FAM234A (family with sequence similarity 234 member A, HGNC:14163) is a protein-coding gene on chromosome 16p13.3, encoding Protein FAM234A (Q9H0X4).

Located in cell surface.

Source: NCBI Gene 83986 — RefSeq curated summary.

At a glance

• GWAS associations: 45
• Clinical variants (ClinVar): 165 total
• MANE Select transcript: NM_032039

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14163
Approved symbol	FAM234A
Name	family with sequence similarity 234 member A
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP761D0211, FLJ32603
Ensembl gene	ENSG00000167930
Ensembl biotype	protein_coding
Entrez	83986

Gene structure

Transcript identifiers

Ensembl transcripts: 105 — 98 protein_coding, 5 nonsense_mediated_decay, 2 retained_intron

ENST00000301678, ENST00000301679, ENST00000399932, ENST00000417499, ENST00000419173, ENST00000420046, ENST00000420500, ENST00000421000, ENST00000424016, ENST00000426695, ENST00000438220, ENST00000447499, ENST00000449945, ENST00000453430, ENST00000468354, ENST00000496874, ENST00000600536, ENST00000653392, ENST00000654053, ENST00000659283, ENST00000666018, ENST00000872365, ENST00000872366, ENST00000872367, ENST00000872368, ENST00000872369, ENST00000872370, ENST00000872371, ENST00000872372, ENST00000872373, ENST00000872374, ENST00000872375, ENST00000872376, ENST00000872377, ENST00000872378, ENST00000872379, ENST00000872380, ENST00000872381, ENST00000872382, ENST00000872383, ENST00000872384, ENST00000872385, ENST00000872386, ENST00000872387, ENST00000872388, ENST00000872389, ENST00000872390, ENST00000872391, ENST00000872392, ENST00000872393, ENST00000872394, ENST00000872395, ENST00000872396, ENST00000872397, ENST00000872398, ENST00000872399, ENST00000872400, ENST00000872401, ENST00000872402, ENST00000872403, ENST00000872404, ENST00000872405, ENST00000872406, ENST00000872407, ENST00000872408, ENST00000872409, ENST00000872410, ENST00000872411, ENST00000872412, ENST00000872413, ENST00000872414, ENST00000872415, ENST00000872416, ENST00000914329, ENST00000914330, ENST00000914331, ENST00000914332, ENST00000914333, ENST00000970190, ENST00000970191, ENST00000970192, ENST00000970193, ENST00000970194, ENST00000970195, ENST00000970196, ENST00000970197, ENST00000970198, ENST00000970200, ENST00000970201, ENST00000970203, ENST00000970204, ENST00000970205, ENST00000970206, ENST00000970207, ENST00000970208, ENST00000970209, ENST00000970210, ENST00000970211, ENST00000970212, ENST00000970213, ENST00000970214, ENST00000970215, ENST00000970216, ENST00000970217, ENST00000970218

RefSeq mRNA: 2 — MANE Select: NM_032039 NM_001284497, NM_032039

CCDS: CCDS10402

Canonical transcript exons

ENST00000399932 — 13 exons

Exon	Start	End
ENSE00001118465	249549	249654
ENSE00001508604	264811	266096
ENSE00001813573	234821	234857
ENSE00003851294	263700	263775
ENSE00003851507	259483	259599
ENSE00003862212	261384	261514
ENSE00003862241	264614	264716
ENSE00003864186	262424	262553
ENSE00003870458	263262	263402
ENSE00003878530	259969	260160
ENSE00003881314	262093	262225
ENSE00003886054	264016	264171
ENSE00003887845	254381	254681

Expression profiles

Bgee: expression breadth ubiquitous, 241 present calls, max score 97.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.6276 / max 124.0650, expressed in 1793 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
151873	11.4538	1785
151874	0.4164	200
151878	0.2975	58
151877	0.1303	36
151880	0.1008	40
151876	0.0970	35
151879	0.0923	36
151875	0.0395	21

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	97.89	gold quality
mucosa of transverse colon	UBERON:0004991	97.29	gold quality
gastrocnemius	UBERON:0001388	97.10	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.76	gold quality
stromal cell of endometrium	CL:0002255	96.47	gold quality
heart left ventricle	UBERON:0002084	96.45	gold quality
right atrium auricular region	UBERON:0006631	96.42	gold quality
muscle of leg	UBERON:0001383	96.27	gold quality
cardiac atrium	UBERON:0002081	96.16	gold quality
cardiac ventricle	UBERON:0002082	96.14	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.14	gold quality
nerve	UBERON:0001021	96.03	gold quality
tibial nerve	UBERON:0001323	96.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	95.89	gold quality
lower esophagus	UBERON:0013473	95.88	gold quality
spinal cord	UBERON:0002240	95.86	gold quality
adenohypophysis	UBERON:0002196	95.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.70	gold quality
muscle layer of sigmoid colon	UBERON:0035805	95.53	gold quality
cardiac muscle of right atrium	UBERON:0003379	95.44	silver quality
left ventricle myocardium	UBERON:0006566	95.42	silver quality
heart	UBERON:0000948	95.36	gold quality
transverse colon	UBERON:0001157	95.11	gold quality
pituitary gland	UBERON:0000007	95.07	gold quality
small intestine Peyer’s patch	UBERON:0003454	95.01	gold quality
right lobe of thyroid gland	UBERON:0001119	94.95	gold quality
popliteal artery	UBERON:0002250	94.91	gold quality
tibial artery	UBERON:0007610	94.90	gold quality
skeletal muscle organ	UBERON:0014892	94.86	gold quality
left coronary artery	UBERON:0001626	94.76	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-125970	yes	16.15
E-MTAB-6142	no	283.78
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

64 targeting FAM234A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-3666	99.90	73.24	1833
HSA-MIR-4295	99.90	73.11	1838
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-3663-3P	99.84	70.39	798
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700
HSA-MIR-152-3P	99.74	73.75	1703
HSA-MIR-6762-3P	99.66	66.94	1188
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	fam234a	ENSDARG00000071449
mus_musculus	Fam234a	ENSMUSG00000024187
rattus_norvegicus	Fam234a	ENSRNOG00000067554
drosophila_melanogaster	CG3618	FBGN0037028
drosophila_melanogaster	CG6184	FBGN0038725

Paralogs (1): FAM234B (ENSG00000084444)

Protein

Protein identifiers

Protein FAM234A — Q9H0X4 (reviewed: Q9H0X4)

Alternative names: Protein ITFG3

All UniProt accessions (13): B4DGG1, C9IYB9, C9J1M4, C9J3Y6, C9J8V3, C9JJN3, Q9H0X4, C9JP72, C9JR71, C9JTF7, C9K0C5, H7C2U8, H7C3L6

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the FAM234 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H0X4-1	1	yes
Q9H0X4-2	2

RefSeq proteins (2): NP_001271426, NP_114428* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011047	Quinoprotein_ADH-like_sf	Homologous_superfamily
IPR045232	FAM234	Family
IPR055409	Beta-prop_FAM234A_B	Domain

Pfam: PF23727

UniProt features (14 total): glycosylation site 4, topological domain 2, splice variant 2, chain 1, sequence conflict 1, transmembrane region 1, region of interest 1, compositionally biased region 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H0X4-F1	81.12	0.41

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 21

Glycosylation sites (4): 473, 116, 314, 389

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 97 (showing top): GOCC_CELL_SURFACE, GTGCCTT_MIR506, DOUGLAS_BMI1_TARGETS_DN, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, TTTGCAC_MIR19A_MIR19B, GAVIN_FOXP3_TARGETS_CLUSTER_P3, NIKOLSKY_BREAST_CANCER_16P13_AMPLICON, WILLIAMS_ESR2_TARGETS_UP, YOSHIMURA_MAPK8_TARGETS_UP, KARLSSON_TGFB1_TARGETS_DN, PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN, GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP, FOXN3_TARGET_GENES, SUPT16H_TARGET_GENES, ZNF184_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): cell surface (GO:0009986), membrane (GO:0016020), extracellular exosome (GO:0070062)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
binding	1
extracellular vesicle	1

Protein interactions and networks

STRING

454 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FAM234A	RNF122	Q9H9V4	464
FAM234A	L3HYPDH	Q96EM0	454
FAM234A	SLC4A5	Q9BY07	451
FAM234A	LUC7L	Q9NQ29	446
FAM234A	KCTD18	Q6PI47	438
FAM234A	FGD4	Q96M96	438
FAM234A	HBQ1	P09105	432
FAM234A	APEH	P13798	429
FAM234A	SLC43A3	Q8NBI5	410
FAM234A	UTP11	Q9Y3A2	405
FAM234A	HBA1	P01922	399
FAM234A	GOSR2	O14653	390
FAM234A	RPL26L1	Q9UNX3	390
FAM234A	SF3B2	Q13435	386
FAM234A	C5orf15	Q8NC54	367

IntAct

72 interactions, top by confidence:

A	B	Type	Score
CD9	ADAM10	psi-mi:“MI:0914”(association)	0.750
KCNJ2	KCNJ18	psi-mi:“MI:2364”(proximity)	0.660
CD27	TCAF2	psi-mi:“MI:0914”(association)	0.640
STX12	SNAP23	psi-mi:“MI:0914”(association)	0.640
STX7	SNAP23	psi-mi:“MI:0914”(association)	0.640
SLC16A2	FAM234A	psi-mi:“MI:0915”(physical association)	0.560
SCGB1D1	FAM234B	psi-mi:“MI:0914”(association)	0.530
XKRX	FAM234B	psi-mi:“MI:0914”(association)	0.530
SLC15A4	PGRMC1	psi-mi:“MI:0914”(association)	0.530
HEATR3	SLC27A2	psi-mi:“MI:0914”(association)	0.530
VAMP5	NBAS	psi-mi:“MI:0914”(association)	0.530
PRRT2	NDUFB3	psi-mi:“MI:0914”(association)	0.530
ANKH	FAM234B	psi-mi:“MI:0914”(association)	0.530
FLVCR1	TNFRSF10B	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
FAM234A	CCR4	psi-mi:“MI:0915”(physical association)	0.370
MME		psi-mi:“MI:0914”(association)	0.350
STX12	NBAS	psi-mi:“MI:0914”(association)	0.350
CD81	STX3	psi-mi:“MI:0914”(association)	0.350
CD81	PVR	psi-mi:“MI:0914”(association)	0.350
CD81	CD276	psi-mi:“MI:0914”(association)	0.350
	SHTN1	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
GPRC5D	FAM234B	psi-mi:“MI:0914”(association)	0.350
VAC14	NUDT19	psi-mi:“MI:0914”(association)	0.350
KIR2DL4	GPR89A	psi-mi:“MI:0914”(association)	0.350

BioGRID (147): ITFG3 (Affinity Capture-MS), ITFG3 (Proximity Label-MS), ITFG3 (Affinity Capture-MS), ITFG3 (Affinity Capture-MS), ITFG3 (Affinity Capture-MS), ITFG3 (Affinity Capture-MS), ITFG3 (Proximity Label-MS), ITFG3 (Proximity Label-MS), ITFG3 (Proximity Label-MS), ITFG3 (Co-fractionation), ITFG3 (Affinity Capture-MS), ITFG3 (Affinity Capture-MS), ITFG3 (Affinity Capture-MS), ITFG3 (Proximity Label-MS), ITFG3 (Proximity Label-MS)

ESM2 similar proteins: A0A8M9PDM1, A2RU67, B8JI67, D3YX43, D3ZWJ9, E1B9E5, O08721, O08722, O60486, P35054, P35916, P35917, Q2HJE5, Q3TYX2, Q5F3L3, Q5M7W6, Q5R6F5, Q62190, Q63961, Q6AXW8, Q6NXM3, Q6P7C7, Q6PVW7, Q6ZN44, Q6ZQQ6, Q76MJ5, Q7TN88, Q80VA5, Q86XM0, Q8BYI8, Q8C0Z1, Q8CB67, Q8IZJ1, Q8K1S3, Q8K1S4, Q8N3G9, Q8TF17, Q8VI51, Q8WY21, Q91ZT1

Diamond homologs: Q2HJE5, Q5F3L3, Q5M7W6, Q8BYI8, Q8C0Z1, Q9H0X4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 95 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Neutrophil degranulation	10	3.9×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

165 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	115
Likely benign	21
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

4918 predictions. Top by Δscore:

Variant	Effect	Δscore
16:249653:AG:A	donor_loss	1.0000
16:249654:GGTA:G	donor_loss	1.0000
16:249655:G:GG	donor_gain	1.0000
16:259481:A:AG	acceptor_gain	1.0000
16:259482:G:GA	acceptor_gain	1.0000
16:259482:GTT:G	acceptor_gain	1.0000
16:261512:G:GT	donor_gain	1.0000
16:262092:GGTTA:G	acceptor_gain	1.0000
16:262417:T:TA	acceptor_gain	1.0000
16:262422:A:AG	acceptor_gain	1.0000
16:262423:G:GG	acceptor_gain	1.0000
16:262423:GC:G	acceptor_gain	1.0000
16:262423:GCA:G	acceptor_gain	1.0000
16:262423:GCAA:G	acceptor_gain	1.0000
16:262539:G:GT	donor_gain	1.0000
16:262550:ACAG:A	donor_loss	1.0000
16:262551:CAGG:C	donor_loss	1.0000
16:262554:G:C	donor_loss	1.0000
16:262554:G:GA	donor_loss	1.0000
16:262555:T:A	donor_loss	1.0000
16:263694:TTCCA:T	acceptor_loss	1.0000
16:263695:TCCAG:T	acceptor_loss	1.0000
16:263696:CCAGA:C	acceptor_loss	1.0000
16:263697:CAGA:C	acceptor_loss	1.0000
16:263697:CAGAA:C	acceptor_loss	1.0000
16:263698:A:AG	acceptor_gain	1.0000
16:263698:A:AT	acceptor_loss	1.0000
16:263699:G:GG	acceptor_gain	1.0000
16:263699:G:GT	acceptor_loss	1.0000
16:263699:GA:G	acceptor_gain	1.0000

AlphaMissense

3602 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:254659:G:C	W82C	0.990
16:254659:G:T	W82C	0.990
16:260030:G:C	W149C	0.990
16:260030:G:T	W149C	0.990
16:254588:T:C	C59R	0.982
16:264902:G:C	K513N	0.982
16:264902:G:T	K513N	0.982
16:254657:T:A	W82R	0.976
16:254657:T:C	W82R	0.976
16:260028:T:A	W149R	0.975
16:260028:T:C	W149R	0.975
16:261397:G:C	W197C	0.971
16:261397:G:T	W197C	0.971
16:259999:C:A	A139D	0.966
16:264136:T:A	W437R	0.966
16:264136:T:C	W437R	0.966
16:264127:T:C	F434L	0.964
16:264129:C:A	F434L	0.964
16:264129:C:G	F434L	0.964
16:259543:T:C	F110S	0.962
16:259533:G:C	D107H	0.956
16:264138:G:C	W437C	0.953
16:264138:G:T	W437C	0.953
16:264710:T:C	F481L	0.953
16:264712:T:A	F481L	0.953
16:264712:T:G	F481L	0.953
16:261384:G:T	G193V	0.950
16:261395:T:A	W197R	0.949
16:261395:T:C	W197R	0.949
16:254601:T:A	V63E	0.943

dbSNP variants (sampled 300 via entrez): RS1000036133 (16:252854 G>A,C,T), RS1000195165 (16:264669 T>C), RS1000250465 (16:238346 C>G), RS1000299354 (16:268363 G>A), RS1000357181 (16:246027 A>G), RS1000444690 (16:267417 C>G,T), RS1000538421 (16:240598 G>A), RS1000568705 (16:260890 G>A,C), RS1000605220 (16:241726 G>A,T), RS1000795379 (16:234251 T>C), RS1000842049 (16:236925 A>G), RS1000907264 (16:254945 T>G), RS1000951616 (16:256443 C>T), RS1001039064 (16:251691 T>C,G), RS1001106998 (16:256696 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (1): breast ductal adenocarcinoma (MONDO:0005590)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

45 associations (top):

Study	Trait	p-value
GCST000503_16	Mean corpuscular volume	2.000000e-12
GCST000504_7	Mean corpuscular hemoglobin	3.000000e-10
GCST000587_1	Mean corpuscular hemoglobin	3.000000e-09
GCST001873_10	Red blood cell traits	7.000000e-24
GCST001873_14	Red blood cell traits	1.000000e-08
GCST001873_15	Red blood cell traits	7.000000e-06
GCST001873_3	Red blood cell traits	3.000000e-23
GCST001873_5	Red blood cell traits	9.000000e-48
GCST001873_6	Red blood cell traits	2.000000e-34
GCST001873_8	Red blood cell traits	4.000000e-22
GCST002027_3	Red blood cell traits	5.000000e-29
GCST002027_4	Red blood cell traits	8.000000e-36
GCST002027_5	Red blood cell traits	9.000000e-17
GCST004004_45	Mean corpuscular volume	1.000000e-46
GCST004005_10	Hemoglobin levels	1.000000e-08
GCST004006_27	Mean corpuscular hemoglobin	2.000000e-21
GCST004007_13	Mean corpuscular hemoglobin concentration	1.000000e-08
GCST004008_10	Red blood cell count	1.000000e-08
GCST004329_8	Mean corpuscular hemoglobin concentration	3.000000e-12
GCST004332_5	Red blood cell count	2.000000e-13
GCST004334_14	Mean corpuscular hemoglobin	4.000000e-42
GCST004335_7	Mean corpuscular volume	6.000000e-30
GCST004602_222	Mean corpuscular volume	8.000000e-09
GCST004894_20	Type 2 diabetes	4.000000e-06
GCST004894_76	Type 2 diabetes	1.000000e-09
GCST005951_12	Body mass index	5.000000e-11
GCST006867_131	Type 2 diabetes	9.000000e-10
GCST006979_945	Heel bone mineral density	2.000000e-11
GCST006979_946	Heel bone mineral density	8.000000e-10
GCST007954_47	Glycated hemoglobin levels	3.000000e-14

EFO canonical traits (12, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin
EFO:0004509	hemoglobin measurement
EFO:0004305	erythrocyte count
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0004340	body mass index
EFO:0009270	heel bone mineral density
EFO:0004541	HbA1c measurement
EFO:0004309	platelet count
EFO:0004833	neutrophil count
EFO:0004842	eosinophil count
EFO:0005090	basophil count
EFO:0005091	monocyte count

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D018270	Carcinoma, Ductal, Breast	C04.557.470.200.025.232.500; C04.557.470.615.132.500; C04.588.180.390; C17.800.090.500.390

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	increases expression	4
bisphenol A	increases expression	2
Acetaminophen	increases expression	2
Tobacco Smoke Pollution	decreases expression, increases expression	2
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
di-n-butylphosphoric acid	affects expression	1
ICG 001	decreases expression	1
jinfukang	increases expression	1
Copper	affects binding, increases expression	1
Disulfiram	affects binding, increases expression	1
Doxorubicin	decreases expression	1
Ivermectin	decreases expression	1
Ribonucleotides	affects binding	1
Silicon Dioxide	decreases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Cadmium Chloride	decreases expression	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

11 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03414970	PHASE3	ACTIVE_NOT_RECRUITING	Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT00461344	PHASE2	TERMINATED	Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
NCT07499999	PHASE2	NOT_YET_RECRUITING	Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
NCT00637364	PHASE1/PHASE2	SUSPENDED	High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain
NCT02779855	PHASE1/PHASE2	COMPLETED	Talimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer
NCT01753908	EARLY_PHASE1	COMPLETED	Broccoli Sprout Extract in Treating Patients With Breast Cancer
NCT01796041	EARLY_PHASE1	COMPLETED	Intraoperative Imaging of Breast Cancer With Indocyanine Green
NCT01208974	Not specified	ACTIVE_NOT_RECRUITING	Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction
NCT01875198	Not specified	TERMINATED	Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer
NCT03543397	Not specified	UNKNOWN	MRI in Ductal Carcinoma in Situ (DCIS)
NCT03834532	Not specified	COMPLETED	Living Well After Breast Surgery