FAM237B

Summary

FAM237B (family with sequence similarity 237 member B, HGNC:53217) is a protein-coding gene on chromosome 7q21.13, encoding Protein FAM237B (A0A1B0GVD1). May be capable of activating GPR83 via the GNAQ signaling pathway.

Predicted to be located in extracellular region.

Source: NCBI Gene 107986818 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001384237

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53217
Approved symbol	FAM237B
Name	family with sequence similarity 237 member B
Location	7q21.13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000283267
Ensembl biotype	protein_coding
Entrez	107986818

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000637645, ENST00000692316

RefSeq mRNA: 1 — MANE Select: NM_001384237 NM_001384237

CCDS: CCDS94139

Canonical transcript exons

ENST00000692316 — 3 exons

Exon	Start	End
ENSE00003930505	90320922	90321304
ENSE00003936580	90316807	90319751
ENSE00003937426	90320681	90320727

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 62.65.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	62.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	59.01	gold quality
prostate gland	UBERON:0002367	50.75	gold quality
fallopian tube	UBERON:0003889	48.48	gold quality
primary visual cortex	UBERON:0002436	47.28	silver quality
cortex of kidney	UBERON:0001225	47.09	gold quality
endometrium	UBERON:0001295	47.05	silver quality
ventricular zone	UBERON:0003053	46.73	gold quality
colonic epithelium	UBERON:0000397	45.76	gold quality
left uterine tube	UBERON:0001303	45.05	gold quality
kidney	UBERON:0002113	44.28	gold quality
mucosa of stomach	UBERON:0001199	43.97	gold quality
right lung	UBERON:0002167	43.90	gold quality
metanephros cortex	UBERON:0010533	43.74	gold quality
adult mammalian kidney	UBERON:0000082	43.08	gold quality
thoracic mammary gland	UBERON:0005200	42.95	gold quality
Brodmann (1909) area 9	UBERON:0013540	42.82	silver quality
left lobe of thyroid gland	UBERON:0001120	42.71	silver quality
thyroid gland	UBERON:0002046	42.48	silver quality
superior frontal gyrus	UBERON:0002661	42.44	gold quality
nucleus accumbens	UBERON:0001882	42.17	silver quality
pituitary gland	UBERON:0000007	42.14	gold quality
omental fat pad	UBERON:0010414	41.92	gold quality
adenohypophysis	UBERON:0002196	41.86	gold quality
caudate nucleus	UBERON:0001873	41.78	silver quality
smooth muscle tissue	UBERON:0001135	41.59	gold quality
adipose tissue	UBERON:0001013	41.36	gold quality
right lobe of thyroid gland	UBERON:0001119	41.31	silver quality
duodenum	UBERON:0002114	41.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands. (PMID:32713278)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Fam237b	ENSMUSG00000073234
rattus_norvegicus	Fam237b	ENSRNOG00000039863

Paralogs (1): FAM237A (ENSG00000235118)

Protein

Protein identifiers

Protein FAM237B — A0A1B0GVD1 (reviewed: A0A1B0GVD1)

All UniProt accessions (1): A0A1B0GVD1

UniProt curated annotations — full annotation on UniProt →

Function. May be capable of activating GPR83 via the GNAQ signaling pathway.

Subcellular location. Secreted.

Post-translational modifications. The active form requires C-terminal amidation and disulfide bond formation.

RefSeq proteins (1): NP_001371166* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR040439	FAM237A/B	Family

UniProt features (4 total): signal peptide 1, chain 1, propeptide 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1B0GVD1-F1	74.64	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 112

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): ZNF618_TARGET_GENES, chr7q21

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

90 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FAM237B	H2AP	O75409	514
FAM237B	TMEM243	Q9BU79	474
FAM237B	RIPPLY3	P57055	419
FAM237B	WFDC1	Q9HC57	372
FAM237B	MRPS5	P82675	368
FAM237B	RHCG	Q9UBD6	364
FAM237B	PGPEP1L	A6NFU8	348
FAM237B	TRIM55	Q9BYV6	322
FAM237B	IMMP2L	Q96T52	320
FAM237B	GPR83	Q9NYM4	314
FAM237B	FXYD3	Q14802	311
FAM237B	PMP2	P02689	309
FAM237B	KCNK1	O00180	309
FAM237B	RLBP1	P12271	235
FAM237B	ATP1A2	P50993	232

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A023PZB3, A0A182BSS2, A0A1B0GVD1, A0A3B7TNM4, B8QCG6, D3Z0R2, F4JYJ1, F5GUE5, H2A0P2, O32528, O56774, O62688, O62689, O62690, O94262, P0CV29, P0DMD1, P22388, P32772, P34290, P34507, P34566, P34890, P40745, P53074, P92560, Q00997, Q03233, Q03703, Q03937, Q09220, Q09280, Q09953, Q12418, Q19541, Q1KN19, Q1X6X8, Q3V0X1, Q54IV8, Q5I123

Diamond homologs: A0A1B0GTK4, A0A1B0GVD1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000443380 (7:90319550 T>G), RS1001326545 (7:90319969 T>G), RS1001430751 (7:90323175 A>G), RS1001897963 (7:90318691 T>A), RS1002193201 (7:90318795 T>C), RS1002327462 (7:90318515 A>T), RS1002990474 (7:90321147 T>A,C), RS1004367135 (7:90321579 T>G), RS1004644132 (7:90323216 T>A), RS1004805405 (7:90317519 T>C,G), RS1005133380 (7:90321305 A>C,G,T), RS1005249333 (7:90319036 T>A,G), RS1005875414 (7:90317380 A>T), RS1006174004 (7:90322826 C>T), RS1006212530 (7:90320636 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.