FAM25G

Summary

FAM25G (family with sequence similarity 25 member G, HGNC:23590) is a protein-coding gene on chromosome 10q11.22, encoding Protein FAM25G (B3EWG6).

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001137549

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23590
Approved symbol	FAM25G
Name	family with sequence similarity 25 member G
Location	10q11.22
Locus type	gene with protein product
Status	Approved
Aliases	bA301J7.4
Ensembl gene	ENSG00000189090
Ensembl biotype	protein_coding
Entrez	100133093

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000452267, ENST00000481177

RefSeq mRNA: 1 — MANE Select: NM_001137549 NM_001137549

CCDS: CCDS73124

Canonical transcript exons

ENST00000452267 — 3 exons

Exon	Start	End
ENSE00002459133	47491602	47491700
ENSE00003504255	47487219	47487408
ENSE00003620249	47489586	47489648

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 92.52.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.52	gold quality
lower esophagus mucosa	UBERON:0035834	84.85	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.57	gold quality
granulocyte	CL:0000094	54.66	gold quality
primary visual cortex	UBERON:0002436	50.85	gold quality
left testis	UBERON:0004533	49.59	gold quality
testis	UBERON:0000473	49.36	gold quality
right testis	UBERON:0004534	45.99	gold quality
vagina	UBERON:0000996	44.29	gold quality
left adrenal gland cortex	UBERON:0035825	43.95	gold quality
nucleus accumbens	UBERON:0001882	42.83	gold quality
esophagus mucosa	UBERON:0002469	42.83	gold quality
cortical plate	UBERON:0005343	42.70	gold quality
skin of abdomen	UBERON:0001416	42.65	gold quality
zone of skin	UBERON:0000014	42.41	gold quality
ventricular zone	UBERON:0003053	42.17	gold quality
endocervix	UBERON:0000458	42.12	gold quality
right uterine tube	UBERON:0001302	41.54	silver quality
skin of leg	UBERON:0001511	41.34	gold quality
putamen	UBERON:0001874	40.86	gold quality
amygdala	UBERON:0001876	40.83	gold quality
temporal lobe	UBERON:0001871	40.68	gold quality
small intestine	UBERON:0002108	40.34	gold quality
Ammon’s horn	UBERON:0001954	39.77	gold quality
right adrenal gland cortex	UBERON:0035827	39.60	gold quality
adenohypophysis	UBERON:0002196	39.57	gold quality
skeletal muscle tissue	UBERON:0001134	38.79	gold quality
small intestine Peyer’s patch	UBERON:0003454	38.71	gold quality
pituitary gland	UBERON:0000007	38.08	gold quality
left adrenal gland	UBERON:0001234	38.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.03

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Fam25a	ENSMUSG00000043681
rattus_norvegicus	Fam25a	ENSRNOG00000055025

Paralogs (2): FAM25A (ENSG00000188100), FAM25C (ENSG00000276430)

Protein

Protein identifiers

Protein FAM25G — B3EWG6 (reviewed: B3EWG6)

All UniProt accessions (1): B3EWG6

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the FAM25 family.

RefSeq proteins (1): NP_001131021* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR023243	FAM25	Family

Pfam: PF15825

UniProt features (1 total): chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-B3EWG6-F1	60.53	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr10q11

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

BioGRID (62): FAM25A (Two-hybrid), FAM25G (Two-hybrid), FAM25C (Two-hybrid), FAM25A (Two-hybrid), FAM25G (Two-hybrid), FAM25C (Two-hybrid), FAM25A (Two-hybrid), FAM25G (Two-hybrid), FAM25C (Two-hybrid), FAM25A (Two-hybrid), FAM25G (Two-hybrid), FAM25C (Two-hybrid), FAM25A (Two-hybrid), FAM25G (Two-hybrid), FAM25C (Two-hybrid)

ESM2 similar proteins: A0A0C4G489, A0A6B9KZ02, A0A6B9L6A5, B3EWG3, B3EWG5, B3EWG6, B4II55, B4PPU6, B9WG30, C0HJX8, D6C4I6, F1T149, F1T150, L0GCW2, O18493, O31557, O96059, O97395, P0DM82, P0DP51, P0DPH1, P0DPH5, P0DQV6, P0DTG2, P0DUE8, P10762, P13404, P21663, P40844, P53707, P80710, P80713, P81605, P82818, P85219, P85222, P86718, P86719, Q07730, Q1JS87

Diamond homologs: B3EWG3, B3EWG5, B3EWG6, Q8CF02

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

331 predictions. Top by Δscore:

Variant	Effect	Δscore
10:47491599:G:GG	donor_gain	1.0000
10:47491603:GCCA:G	donor_gain	1.0000
10:47491606:G:GT	donor_gain	1.0000
10:47487407:G:GG	acceptor_gain	0.9900
10:47487407:GCC:G	acceptor_gain	0.9900
10:47487407:GCCAT:G	acceptor_gain	0.9900
10:47487408:A:AG	acceptor_gain	0.9900
10:47489585:AGGTA:A	donor_loss	0.9900
10:47489587:AAAG:A	donor_loss	0.9900
10:47489647:G:GC	acceptor_gain	0.9900
10:47489647:GTT:G	acceptor_gain	0.9900
10:47489647:GTTC:G	acceptor_gain	0.9900
10:47489648:A:AG	acceptor_gain	0.9900
10:47489649:CAGTT:C	acceptor_loss	0.9900
10:47489650:TCA:T	acceptor_loss	0.9900
10:47489651:TTCAG:T	acceptor_loss	0.9900
10:47489653:T:TA	acceptor_gain	0.9900
10:47491587:G:GT	donor_gain	0.9900
10:47491594:G:GT	donor_gain	0.9900
10:47487407:GC:G	acceptor_gain	0.9800
10:47487407:GCCA:G	acceptor_gain	0.9800
10:47487409:CA:C	acceptor_loss	0.9800
10:47487410:A:G	acceptor_gain	0.9800
10:47487410:ACAG:A	acceptor_loss	0.9800
10:47487411:A:AG	acceptor_gain	0.9800
10:47489588:GAAAG:G	donor_gain	0.9800
10:47489647:GT:G	acceptor_gain	0.9800
10:47489647:GTTCA:G	acceptor_gain	0.9800
10:47491586:G:T	donor_gain	0.9800
10:47491605:G:T	donor_gain	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1156321166 (10:47493222 C>T), RS1156526321 (10:47490974 C>T), RS1156708409 (10:47491899 CCT>C), RS1156879222 (10:47489640 C>T), RS1156902140 (10:47492545 C>T), RS1157157178 (10:47490358 G>A,C), RS1157389780 (10:47488980 G>A), RS1157957388 (10:47486745 T>A), RS1157984606 (10:47487563 G>C), RS1158493618 (10:47492917 C>T), RS1158611185 (10:47493588 C>T), RS1158760513 (10:47490616 C>A), RS1159138433 (10:47492269 G>A,T), RS1159356846 (10:47487446 G>A), RS1159517849 (10:47488430 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.