FAM27D1

Summary

FAM27D1 (family with sequence similarity 27 member D1, HGNC:32015) is a long non-coding RNA gene on chromosome 9p11.2.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32015
Approved symbol	FAM27D1
Name	family with sequence similarity 27 member D1
Location	9p11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	OTTHUMG00000013267
Entrez	724094

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Protein FAM27D1 — Q5T7N8 (reviewed: Q5T7N8)

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the FAM27 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR031672	FAM27D/FAM27E	Family

Pfam: PF15832

UniProt features (8 total): compositionally biased region 5, chain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T7N8-F1	57.39	0.04

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A023PXD3, A4IFR0, A6NGG3, A6NJ64, A8K010, B9ELP3, E5RJ46, E9PJI5, F8WFD2, G2TRS0, P04610, P08347, P0C1K1, P0C7M3, P0C7Q2, P0CG42, P0DM63, P16803, P20893, P22496, P25352, P27982, P33460, P37125, P40205, P61583, P64570, P64571, P92537, Q08E93, Q3SY05, Q4ZGE2, Q52M58, Q5T7N8, Q6NUI1, Q6ZS52, Q6ZTI0, Q6ZTR6, Q86UQ5, Q89565

Diamond homologs: Q08E93, Q5T7N8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Formaldehyde	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.