FAM27E3

Summary

FAM27E3 (family with sequence similarity 27 member E3, HGNC:28655) is a long non-coding RNA gene on chromosome 9q21.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28655
Approved symbol	FAM27E3
Name	family with sequence similarity 27 member E3
Location	9q21.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC42630
Ensembl gene	ENSG00000274026
Ensembl biotype	lncRNA
Entrez	100131997
RNAcentral	URS000075C54C — lncRNA, 1521 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 30 lncRNA

ENST00000418795, ENST00000792978, ENST00000792979, ENST00000792980, ENST00000792981, ENST00000792982, ENST00000792983, ENST00000792984, ENST00000792985, ENST00000792986, ENST00000792987, ENST00000792988, ENST00000792989, ENST00000792990, ENST00000792991, ENST00000792992, ENST00000792993, ENST00000792994, ENST00000792995, ENST00000792996, ENST00000792997, ENST00000792998, ENST00000792999, ENST00000793000, ENST00000793001, ENST00000793002, ENST00000793003, ENST00000793004, ENST00000793005, ENST00000793006

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418795 — 3 exons

Exon	Start	End
ENSE00004175384	67719150	67719526
ENSE00004175404	67717411	67718974
ENSE00004175412	67726451	67726670

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 88.11.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.11	gold quality
right uterine tube	UBERON:0001302	87.88	gold quality
sural nerve	UBERON:0015488	86.20	gold quality
left testis	UBERON:0004533	84.77	gold quality
right testis	UBERON:0004534	84.13	gold quality
ventricular zone	UBERON:0003053	84.03	gold quality
testis	UBERON:0000473	83.66	gold quality
adenohypophysis	UBERON:0002196	83.33	gold quality
nucleus accumbens	UBERON:0001882	82.85	gold quality
pituitary gland	UBERON:0000007	82.66	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.54	gold quality
caudate nucleus	UBERON:0001873	80.48	gold quality
cerebellar hemisphere	UBERON:0002245	80.30	gold quality
cerebellar cortex	UBERON:0002129	80.21	gold quality
putamen	UBERON:0001874	80.18	gold quality
cerebellum	UBERON:0002037	80.14	gold quality
cortical plate	UBERON:0005343	79.15	gold quality
Ammon’s horn	UBERON:0001954	78.24	gold quality
ganglionic eminence	UBERON:0004023	77.91	gold quality
lower esophagus mucosa	UBERON:0035834	77.52	gold quality
adult mammalian kidney	UBERON:0000082	77.28	gold quality
hypothalamus	UBERON:0001898	76.80	gold quality
anterior cingulate cortex	UBERON:0009835	76.72	gold quality
brain	UBERON:0000955	76.54	gold quality
colonic epithelium	UBERON:0000397	76.43	gold quality
kidney	UBERON:0002113	75.98	gold quality
metanephros cortex	UBERON:0010533	75.76	gold quality
amygdala	UBERON:0001876	75.68	gold quality
temporal lobe	UBERON:0001871	75.49	gold quality
right frontal lobe	UBERON:0002810	74.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.