FAM27E4

Summary

FAM27E4 (family with sequence similarity 27 member E4, HGNC:44415) is a long non-coding RNA gene on chromosome 9q13.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44415
Approved symbol	FAM27E4
Name	family with sequence similarity 27 member E4
Location	9q13
Locus type	RNA, long non-coding
Status	Approved
Entrez	107987001

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1005402717 (9:61857118 T>C,G), RS1006957332 (9:61862707 T>G), RS1011794800 (9:61864581 G>A), RS1012264263 (9:61853830 C>G,T), RS1015085979 (9:61853920 G>A,T), RS1016243275 (9:61857052 C>A), RS1022003727 (9:61862750 T>C,G), RS1022305266 (9:61864652 C>T), RS1022448777 (9:61854011 A>G,T), RS1023530001 (9:61857148 C>T), RS1028240393 (9:61857040 G>A,T), RS1028664400 (9:61856897 G>A,C,T), RS1029259387 (9:61853965 C>T), RS1029639062 (9:61862683 C>G,T), RS1030740043 (9:61864793 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
ICG 001	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.