FAM30A

Summary

FAM30A (family with sequence similarity 30 member A, HGNC:19955) is a long non-coding RNA gene on chromosome 14q32.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19955
Approved symbol	FAM30A
Name	family with sequence similarity 30 member A
Location	14q32.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	HSPC053
Ensembl gene	ENSG00000226777
Ensembl biotype	lncRNA
OMIM	616623
Entrez	9834
RNAcentral	URS000075B927 — lncRNA, 9643 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000414005, ENST00000418566, ENST00000619942, ENST00000628159, ENST00000628233, ENST00000629589, ENST00000630242, ENST00000631009, ENST00000689219, ENST00000693413, ENST00000701882, ENST00000701894, ENST00000701943, ENST00000716883

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414005 — 2 exons

Exon	Start	End
ENSE00001602505	105890084	105890197
ENSE00001740412	105895983	105896109

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 94.19.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1106 / max 26.4915, expressed in 30 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
141981	0.1106	30

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	94.19	gold quality
spleen	UBERON:0002106	93.76	gold quality
bone marrow cell	CL:0002092	92.50	gold quality
vermiform appendix	UBERON:0001154	88.58	gold quality
bone marrow	UBERON:0002371	88.21	gold quality
granulocyte	CL:0000094	87.47	gold quality
mucosa of transverse colon	UBERON:0004991	86.92	gold quality
rectum	UBERON:0001052	86.28	gold quality
colonic epithelium	UBERON:0000397	84.52	gold quality
tonsil	UBERON:0002372	84.48	gold quality
blood	UBERON:0000178	82.93	gold quality
small intestine Peyer’s patch	UBERON:0003454	82.66	gold quality
small intestine	UBERON:0002108	82.06	gold quality
duodenum	UBERON:0002114	81.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.60	gold quality
leukocyte	CL:0000738	77.99	gold quality
monocyte	CL:0000576	77.28	gold quality
gall bladder	UBERON:0002110	75.65	gold quality
saliva-secreting gland	UBERON:0001044	75.49	gold quality
minor salivary gland	UBERON:0001830	75.31	gold quality
transverse colon	UBERON:0001157	75.12	gold quality
intestine	UBERON:0000160	74.82	gold quality
colon	UBERON:0001155	71.28	gold quality
urinary bladder	UBERON:0001255	70.33	gold quality
stomach	UBERON:0000945	67.09	gold quality
sural nerve	UBERON:0015488	66.91	gold quality
fundus of stomach	UBERON:0001160	66.86	gold quality
body of stomach	UBERON:0001161	66.66	gold quality
upper lobe of left lung	UBERON:0008952	65.30	gold quality
lung	UBERON:0002048	65.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	15.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• In an analysis of an independent validation cohort, KIAA0125 again showed a significant influence with respect to the impact of the RUNX1/RUNX1T1 fusion in mediation of acute myeloid leukemia. (PMID:30050054)
• The lncRNA KIAA0125 is likely involved in the ameloblastoma pathobiology (PMID:30595406)
• Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125. (PMID:33225420)
• The expression levels of long non-coding RNA KIAA0125 are associated with distinct clinical and biological features in myelodysplastic syndromes. (PMID:33249572)
• Genetic factors in the pathogenesis of ameloblastoma, dentigerous cyst and odontogenic keratocyst. (PMID:33346102)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.